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Piperidone
Piperidinones or piperidones are a class of chemical compounds sharing the piperidone skeleton. A classic named reaction for the synthesis of piperidones is the Petrenko-Kritschenko piperidone synthesis which involves combining an alkyl-1,3-acetonedicarboxylate with benzaldehyde and an amine. This multicomponent reaction is related to the Hantzsch pyridine synthesis. Piperidinones * 2-Piperidinone 2-Piperidinone (2-piperidone or δ-valerolactam) is an organic compound with the formula . Valerolactam is formed by dehydrogenation of 5-amino-1-pentanol, catalyzed by rhodium and ruthenium complexes, The compound, a colorless solid, is classifi ... * 3-Piperidinone * 4-Piperidinone References {{chemistry index Piperidinones ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-Piperidinone
4-Piperidone is an organic compound with the molecular formula . It can be viewed as a derivative of piperidine. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs. Substituted and dehydro derivatives of 4-piperidinone are intermediates in alkaloid syntheses. The N-protonated derivative is typically isolated as the hydrate . It is a DEA list of chemicals, List I chemical in the United States as it is a precursor to fentanyl. See also * 4-Pyridone *1-Methyl-4-piperidone References 4-Piperidinones, {{Heterocyclic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Petrenko-Kritschenko Piperidone Synthesis
The Petrenko-Kritschenko reaction is a classic multicomponent-name reactionJie-Jack Li; "Name reactions in heterocyclic chemistry"; 2005 John Wiley & Sons; ; pp313 that is closely related to the Robinson–Schöpf tropinone synthesis, but was published 12 years earlier. Classic reaction In the original publicationP. Petrenko-Kritschenko "Über die Kondensation des Acetondicarbonsäureesters mit Aldehyden, Ammoniak und Aminen" Journal für Praktische Chemie Volume 85, Issue 1, pages 1–37, 20 May 1912; diethyl-α-ketoglurate, a derivative of acetonedicarboxylic acid, is used in combination with ammonia and benzaldehyde. The relative stereochemistry was not elucidated in the original publication, structural analysis using X-rays or NMR was not available in these days. In the absence of ammonia or ammonium salts a 4-oxotetrahydropyran is formed.P. Petrenko-Kritschenko "Über Tetrahydropyronverbindungen" Journal für Praktische Chemie; Volume 60, Issue 1, pages 140–158, 27 Decembe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
