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Paul Gelmo
Paul Josef Jakob Gelmo (17 December 1879 – 22 October 1961) was an Austrian chemist who worked on synthetic dyes and discovered sulfanilamide in 1908, although their antibiotic properties were discovered only in 1932. Gelmo was born in Vienna and went to the Technische Hochschule where he received a diploma in 1903 and a doctorate in 1906. He then worked with Wilhelm Suida. During this period he examined azo dyes and synthesized several compounds, including sulfanilamide for applications in dyeing. From 1910 he worked as chief chemist for the Austrian Printing Office, and in 1929 he became a lecturer in chemistry at the Technische Hochschule. In 1932 Gerhard Domagk found that the dye prontosil inhibited streptococci and the active metabolite An active metabolite, or pharmacologically active metabolite is a biologically active metabolite of a xenobiotic substance, such as a drug or environmental chemical. Active metabolites may produce therapeutic effects, as well as harmful e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synthetic Dyes
A Colourant, colorant is any substance that changes the spectral transmittance or reflectance of a material. Synthetic colorants are those created in a laboratory or industrial setting. The production and improvement of colorants was a driver of the early synthetic chemical industry, in fact many of today's largest chemical producers started as dye-works in the late 19th or early 20th centuries, including Bayer AG (1863). Synthetics are extremely attractive for industrial and aesthetic purposes as they have they often achieve higher intensity and Colour fastness, color fastness than comparable natural pigments and dyes used since ancient times. Market viable large scale production of dyes occurred nearly simultaneously in the early major producing countries Britain (1857), France (1858), Germany (1858), and Switzerland (1859), and expansion of associated chemical industries followed. The mid-nineteenth century through WWII saw an incredible expansion of the variety and scale of manuf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfanilamide
Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. Chemically, it is an organic compound consisting of an aniline derivatized with a sulfonamide group. Powdered sulfanilamide was used by the Allies in World War II to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to previous wars. Sulfanilamide is rarely if ever used systemically due to toxicity and because more effective sulfonamides are available for this purpose. Modern antibiotics have supplanted sulfanilamide on the battlefield; however, sulfanilamide remains in use today in the form of topical preparations, primarily for treatment of vaginal yeast infections such as vulvovaginitis caused by '' Candida albicans''. The term "sulfanilamides" is also sometimes used to describe a family of molecules containing these functional groups. Examples include: * Furosemide, a loop diuretic * Sulfadiazine, an antibiotic * Sulfamethoxazole, an antibio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TU Wien
TU Wien () is a public research university in Vienna, Austria. The university's teaching and research are focused on engineering, computer science, and natural sciences. It currently has about 28,100 students (29% women), eight faculties, and about 5,000 staff members (3,800 academics). History The institution was founded in 1815 by Emperor Francis I of Austria as the '' k.k. Polytechnisches Institut'' (). The first rector was Johann Joseph von Prechtl. It was renamed the ''Technische Hochschule'' () in 1872. In 1975, it was renamed ''Technische Universität Wien'' (). Academic reputation As a university of technology, TU Wien covers a wide spectrum of scientific concepts from abstract pure research and the fundamental principles of science to applied technological research and partnership with industry. TU Wien is ranked #190 by the QS World University Ranking, #406 by the Center of World University Rankings, and it is positioned among the best 251-300 higher education ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctorate
A doctorate (from Latin ''doctor'', meaning "teacher") or doctoral degree is a postgraduate academic degree awarded by universities and some other educational institutions, derived from the ancient formalism '' licentia docendi'' ("licence to teach"). In most countries, a research degree qualifies the holder to teach at university level in the degree's field or work in a specific profession. There are a number of doctoral degrees; the most common is the Doctor of Philosophy (PhD), awarded in many different fields, ranging from the humanities to scientific disciplines. Many universities also award honorary doctorates to individuals deemed worthy of special recognition, either for scholarly work or other contributions to the university or society. History Middle Ages The term ''doctor'' derives from Latin, meaning "teacher" or "instructor". The doctorate (Latin: ''doctoratus'') appeared in medieval Europe as a license to teach Latin (''licentia docendi'') at a university. Its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wilhelm Suida
Wilhelm may refer to: People and fictional characters * William Charles John Pitcher, costume designer known professionally as "Wilhelm" * Wilhelm (name), a list of people and fictional characters with the given name or surname Other uses * Wilhelm (name), disambiguation page for people named Wilhelm ** Wilhelm II (1858–1941), king of Prussia and emperor of Germany from 1888 until his abdication in 1918. * Mount Wilhelm, the highest mountain in Papua New Guinea * Wilhelm Archipelago, Antarctica * Wilhelm (crater), a lunar crater * Wilhelm scream, stock sound effect used in many movies and shows See also * Wilhelm scream, a stock sound effect * SS ''Kaiser Wilhelm II'', or USS ''Agamemnon'', a German steam ship * Wilhelmus, the Dutch national anthem * William Helm William Helm (March 9, 1837 – April 10, 1919) was an American Sheep-rearing, sheep farmer and among the early pioneer settlers of Fresno County, California, Fresno County, California. He was instrumental in t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azo Dye
Azo dyes are organic compounds bearing the functional group R−N=N−R′, in which R and R′ are usually aryl and substituted aryl groups. They are a commercially important family of azo compounds, i.e. compounds containing the C−N=N−C linkage. Azo dyes are synthetic dyes and do not occur naturally. Most azo dyes contain only one azo group but there are some that contain two or three azo groups, called "diazo dyes" and "triazo dyes" respectively. Azo dyes comprise 60–70% of all dyes used in food and textile industries. Azo dyes are widely used to treat textiles, leather articles, and some foods. Chemically related derivatives of azo dyes include azo pigments, which are insoluble in water and other solvents. Classes Many kinds of azo dyes are known, and several classification systems exist. Some classes include disperse dyes, metal-complex dyes, reactive dyes, and substantive dyes. Also called direct dyes, substantive dyes are employed for cellulose-based textil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerhard Domagk
Gerhard Johannes Paul Domagk (; 30 October 1895 – 24 April 1964) was a German pathologist and bacteriologist. He is credited with the discovery of Sulfonamide (medicine), sulfonamidochrysoidine (KL730) as an antibiotic for which he received the 1939 Nobel Prize in Physiology or Medicine. The drug became the first commercially available antibiotic and marketed under the brand name Prontosil. While working in the pathology department of the University of Münster, Domagk was invited to join the IG Farben branch at Elberfeld (later Wuppertal) in 1927. His duty was to test chemical compounds prepared at the IG Farben laboratory for potential drugs. A novel compound synthesised by Friedrich Mietzsch and Joseph Klarer, a benzene derivative of azo dye attached with sulphonamide group as a side chain was found to have antibacterial activity against human bacterium ''Streptococcus pyogenes.'' In 1935, Domagk's only daughter, Hildegarde, injured herself and contracted a streptococcal in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prontosil
Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria. One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist. The discovery and development of this first sulfonamide-containing drug opened a new era in medicine, because it greatly widened the success of antimicrobial chemotherapy in an era when many physicians doubted its still largely untapped potential. At the time, disinfectant cleaners and topical antiseptic wound care were widely used but there were very few antimicrobial drugs to use safely inside living bodies. Antibiotic drugs derived from microbes, which are relied on heavily today, did not yet exist. Prontosil was discovered in 1932 by a research team at the Bayer Laboratories of the IG Farben conglomerate in Germany led by Gerhard Domagk. Domagk received the 1939 Nobel Prize in Physiol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptococci
''Streptococcus'' is a genus of gram-positive spherical bacteria that belongs to the family Streptococcaceae, within the order Lactobacillales (lactic acid bacteria), in the phylum Bacillota. Cell division in streptococci occurs along a single axis, thus when growing they tend to form pairs or chains, which may appear bent or twisted. This differs from staphylococci, which divide along multiple axes, thereby generating irregular, grape-like clusters of cells. Most streptococci are oxidase-negative and catalase-negative, and many are facultative anaerobes (capable of growth both aerobically and anaerobically). The term was coined in 1877 by Viennese surgeon Albert Theodor Billroth (1829–1894), by combining the prefix "strepto-" (from ), together with the suffix "-coccus" (from Modern , from .) In 1984, many bacteria formerly grouped in the genus ''Streptococcus'' were separated out into the genera '' Enterococcus'' and '' Lactococcus''. Currently, over 50 species are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Active Metabolite
An active metabolite, or pharmacologically active metabolite is a biologically active metabolite of a xenobiotic substance, such as a drug or environmental chemical. Active metabolites may produce therapeutic effects, as well as harmful effects. Metabolites of drugs An active metabolite results when a drug is metabolized by the body into a modified form which produces effects in the body. Usually these effects are similar to those of the parent drug but weaker, although they can still be significant (see e.g. 11-hydroxy-THC, morphine-6-glucuronide). Certain drugs such as codeine and tramadol have metabolites (morphine and ''O''-desmethyltramadol respectively) that are stronger than the parent drug and in these cases the metabolite may be responsible for much of the therapeutic action of the parent drug. Sometimes, however, metabolites may produce toxic effects and patients must be monitored carefully to ensure they do not build up in the body. This is an issue with some well ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1879 Births
Events January * January 1 ** The Specie Resumption Act takes effect. The United States Note is valued the same as gold, for the first time since the American Civil War. ** Brahms' Violin Concerto is premiered in Leipzig with Joseph Joachim as soloist and the composer conducting. * January 11 – The Anglo-Zulu War begins. * January 22 – Anglo-Zulu War – Battle of Isandlwana: A force of 1,200 British soldiers is wiped out by over 20,000 Zulu warriors. * January 23 – Anglo-Zulu War – Battle of Rorke's Drift: Following the previous day's defeat, a smaller British force of 140 successfully repels an attack by 4,000 Zulus. February * February 3 – Mosley Street in Newcastle upon Tyne (England) becomes the world's first public highway to be lit by the electric incandescent light bulb invented by Joseph Swan. * February 8 – At a meeting of the Royal Canadian Institute, engineer and inventor Sandford Fleming first proposes the global ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1961 Deaths
Events January * January 1 – Monetary reform in the Soviet Union, 1961, Monetary reform in the Soviet Union. * January 3 ** United States President Dwight D. Eisenhower announces that the United States has severed diplomatic and consular relations with Cuba (Cuba–United States relations are restored in 2015). ** Aero Flight 311 (Koivulahti air disaster): Douglas DC-3C OH-LCC of Finnish airline Finnair, Aero crashes near Kvevlax (Koivulahti), on approach to Vaasa Airport in Finland, killing all 25 on board, due to pilot error: an investigation finds that the Captain (civil aviation), captain and First officer (civil aviation), first officer were both exhausted for lack of sleep, and had consumed excessive amounts of alcohol at the time of the crash. It remains the deadliest air disaster to occur in the country. * January 5 ** Italian sculptor Alfredo Fioravanti enters the U.S. Consulate in Rome, and confesses that he was part of the team that forged the Etruscan terra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
