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Gerhard Domagk
Gerhard Johannes Paul Domagk (; 30 October 1895 – 24 April 1964) was a German pathologist and bacteriologist. He is credited with the discovery of sulfonamidochrysoidine (KL730) as an antibiotic for which he received the 1939 Nobel Prize in Physiology or Medicine. The drug became the first commercially available antibiotic and marketed under the brand name Prontosil. While working in the pathology department of the University of Münster, Domagk was invited to join the IG Farben branch at Elberfeld (later Wuppertal) in 1927. His duty was to test chemical compounds prepared at the IG Farben laboratory for potential drugs. A novel compound synthesised by Friedrich Mietzsch and Joseph Klarer, a benzene derivative of azo dye attached with sulphonamide group as a side chain was found to have antibacterial activity against human bacterium ''Streptococcus pyogenes.'' In 1935, Domagk's only daughter, Hildegarde, injured herself and contracted a streptococcal infection. In a despe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Province Of Brandenburg
The Province of Brandenburg (german: Provinz Brandenburg) was a province of Prussia from 1815 to 1945. Brandenburg was established in 1815 from the Kingdom of Prussia's core territory, comprised the bulk of the historic Margraviate of Brandenburg (excluding Altmark) and the Lower Lusatia region, and became part of the German Empire in 1871. From 1918, Brandenburg was a province of the Free State of Prussia until it was dissolved in 1945 after World War II, and replaced with reduced territory as the State of Brandenburg in East Germany, which was later dissolved in 1952. Following the reunification of Germany in 1990, Brandenburg was re-established as a federal state of Germany, becoming one of the new states. Brandenburg's provincial capital alternated between Potsdam, Berlin, and Charlottenburg during its existence. Geography The province comprised large parts of the North German Plain, stretching from the Elbe river in the west to beyond the Oder in the east, where the Neuma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fellow Of The Royal Society
Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathematics, engineering science, and medical science". Fellowship of the Society, the oldest known scientific academy in continuous existence, is a significant honour. It has been awarded to many eminent scientists throughout history, including Isaac Newton (1672), Michael Faraday (1824), Charles Darwin (1839), Ernest Rutherford (1903), Srinivasa Ramanujan (1918), Albert Einstein (1921), Paul Dirac (1930), Winston Churchill (1941), Subrahmanyan Chandrasekhar (1944), Dorothy Hodgkin (1947), Alan Turing (1951), Lise Meitner (1955) and Francis Crick (1959). More recently, fellowship has been awarded to Stephen Hawking (1974), David Attenborough (1983), Tim Hunt (1991), Elizabeth Blackburn (1992), Tim Berners-Lee (2001), Venki Ramakrishnan ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lubsko
Lubsko (german: Sommerfeld, Lower Sorbian: ''Žemŕ''), formerly Zemsz, is a town in Żary County in the Lubusz Voivodeship in western Poland. It is the administrative seat of the Gmina Lubsko and has a population of 13,921 (2019). History In the early Middle Ages there was a West Slavic or Lechitic stronghold here, followed by a market settlement on the border between Poland and Lusatia. Probably its oldest name was ''Żemrje''. It is located within Lower Lusatia, but at some times it also belonged to Silesia, e.g. under the Polish rulers Bolesław the Brave and Henry the Bearded. The town was first documented in 1258 and received town privileges by the Lusatian margrave Henry III of Wettin in 1283. The name ''Sommerfeld'', German for "summer field", already appeared in an 1106 deed allegedly issued by margrave Henry I of Wettin, who nevertheless had died three years before. The Wettin margraves sold the town to Brandenburg in 1304. Given in pawn several times, Emperor Cha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nazi Germany
Nazi Germany (lit. "National Socialist State"), ' (lit. "Nazi State") for short; also ' (lit. "National Socialist Germany") (officially known as the German Reich from 1933 until 1943, and the Greater German Reich from 1943 to 1945) was the German Reich, German state between 1933 and 1945, when Adolf Hitler and the Nazi Party controlled the country, transforming it into a dictatorship. Under Hitler's rule, Germany quickly became a totalitarian state where nearly all aspects of life were controlled by the government. The Third Reich, meaning "Third Realm" or "Third Empire", alluded to the Nazi claim that Nazi Germany was the successor to the earlier Holy Roman Empire (800–1806) and German Empire (1871–1918). The Third Reich, which Hitler and the Nazis referred to as the Thousand-Year Reich, ended in May 1945 after just 12 years when the Allies of World War II, Allies defeated Germany, End of World War II in Europe, ending World War II in Europe. On 30 January 1933, H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptococcal Infection
''Streptococcus'' is a genus of gram-positive ' (plural ) or spherical bacteria that belongs to the family Streptococcaceae, within the order Lactobacillales (lactic acid bacteria), in the phylum Bacillota. Cell division in streptococci occurs along a single axis, so as they grow, they tend to form pairs or chains that may appear bent or twisted. This differs from staphylococci, which divide along multiple axes, thereby generating irregular, grape-like clusters of cells. Most streptococci are oxidase-negative and catalase-negative, and many are facultative anaerobes (capable of growth both aerobically and anaerobically). The term was coined in 1877 by Viennese surgeon Albert Theodor Billroth (1829–1894), by combining the prefix "strepto-" (from ), together with the suffix "-coccus" (from Modern , from .) In 1984, many bacteria formerly grouped in the genus ''Streptococcus'' were separated out into the genera ''Enterococcus'' and '' Lactococcus''. Currently, over 50 speci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptococcus Pyogenes
''Streptococcus pyogenes'' is a species of Gram-positive, aerotolerant bacteria in the genus '' Streptococcus''. These bacteria are extracellular, and made up of non-motile and non-sporing cocci (round cells) that tend to link in chains. They are clinically important for humans, as they are an infrequent, but usually pathogenic, part of the skin microbiota that can cause Group A streptococcal infection. ''S. pyogenes'' is the predominant species harboring the Lancefield group A antigen, and is often called group A ''Streptococcus'' (GAS). However, both '' Streptococcus dysgalactiae'' and the '' Streptococcus anginosus'' group can possess group A antigen as well. Group A streptococci, when grown on blood agar, typically produce small (2–3 mm) zones of beta-hemolysis, a complete destruction of red blood cells. The name group A (beta-hemolytic) ''Streptococcus'' (GABHS) is thus also used. The species name is derived from Greek words meaning 'a chain' () of berri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Side Chain
In organic chemistry and biochemistry, a side chain is a chemical group that is attached to a core part of the molecule called the "main chain" or backbone. The side chain is a hydrocarbon branching element of a molecule that is attached to a larger hydrocarbon backbone. It is one factor in determining a molecule's properties and reactivity. A side chain is also known as a pendant chain, but a pendant group (side group) has a different definition. Conventions The placeholder R is often used as a generic placeholder for alkyl (saturated hydrocarbon) group side chains in chemical structure diagrams. To indicate other non-carbon groups in structure diagrams, X, Y, or Z are often used. History The ''R'' symbol was introduced by 19th-century French chemist Charles Frédéric Gerhardt, who advocated its adoption on the grounds that it would be widely recognizable and intelligible given its correspondence in multiple European languages to the initial letter of "root" or "residue": ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulphonamide
In organic chemistry, the sulfonamide functional group (also spelled sulphonamide) is an organosulfur group with the structure . It consists of a sulfonyl group () connected to an amine group (). Relatively speaking this group is unreactive. Because of the rigidity of the functional group, sulfonamides are typically crystalline; for this reason, the formation of a sulfonamide is a classic method to convert an amine into a crystalline derivative which can be identified by its melting point. Many important drugs contain the sulfonamide group. A sulfonamide (compound) is a chemical compound that contains this group. The general formula is or , where each R is some organic group; for example, "methanesulfonamide" (where R = methane, R' = R" = hydrogen) is . Any sulfonamide can be considered as derived from a sulfonic acid by replacing a hydroxyl group () with an amine group. In medicine, the term "sulfonamide" is sometimes used as a synonym for sulfa drug, a derivative or va ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azo Dye
Azo dyes are organic compounds bearing the functional group R−N=N−R′, in which R and R′ are usually aryl and substituted aryl groups. They are a commercially important family of azo compounds, i.e. compounds containing the C-N=N-C linkage. Azo dyes are synthetic dyes and do not occur naturally. Most azo dyes contain only one azo group, but some dyes called "disazo dyes" contain two azo groups, some dyes called "trisazo dyes" contain three azo groups and are or more. Azo dyes comprise 60-70% of all dyes used in food and textile industries. Azo dyes are widely used to treat textiles, leather articles, and some foods. Chemically related derivatives of azo dyes include azo pigments, which are insoluble in water and other solvents. Classes Many kinds of azo dyes are known, and several classification systems exist. Some classes include disperse dyes, metal-complex dyes, reactive dyes, and substantive dyes. Also called direct dyes, substantive dyes are employed f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wuppertal
Wuppertal (; "'' Wupper Dale''") is, with a population of approximately 355,000, the seventh-largest city in North Rhine-Westphalia as well as the 17th-largest city of Germany. It was founded in 1929 by the merger of the cities and towns of Elberfeld, Barmen, Ronsdorf, Cronenberg and Vohwinkel, and was initially "Barmen-Elberfeld" before adopting its present name in 1930. It is regarded as the capital and largest city of the Bergisches Land (historically this was Düsseldorf). The city straddles the densely populated banks of the River Wupper, a tributary of the Rhine called ''Wipper'' in its upper course. Wuppertal is located between the Ruhr (Essen) to the north, Düsseldorf to the west, and Cologne to the southwest, and over time has grown together with Solingen, Remscheid and Hagen. The stretching of the city in a long band along the narrow Wupper Valley leads to a spatial impression of Wuppertal being larger than it actually is. The city is known for its s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IG Farben
Interessengemeinschaft Farbenindustrie AG (), commonly known as IG Farben (German for 'IG Dyestuffs'), was a German chemical and pharmaceutical conglomerate. Formed in 1925 from a merger of six chemical companies— BASF, Bayer, Hoechst, Agfa, Chemische Fabrik Griesheim-Elektron, and Chemische Fabrik vorm. Weiler Ter Meer—it was seized by the Allies after World War II and divided back into its constituent companies. IG Farben was once the largest company in Europe and the largest chemical and pharmaceutical company in the world. IG Farben scientists made fundamental contributions to all areas of chemistry and the pharmaceutical industry. Otto Bayer discovered the polyaddition for the synthesis of polyurethane in 1937, and three company scientists became Nobel laureates: Carl Bosch and Friedrich Bergius in 1931 "for their contributions to the invention and development of chemical high pressure methods", and Gerhard Domagk in 1939 "for the discovery of the antibacterial ef ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Münster
The University of Münster (german: Westfälische Wilhelms-Universität Münster, WWU) is a public research university located in the city of Münster, North Rhine-Westphalia in Germany. With more than 43,000 students and over 120 fields of study in 15 departments, it is Germany's fifth largest university and one of the foremost centers of German intellectual life. The university offers a wide range of subjects across the sciences, social sciences and the humanities. Several courses are also taught in English, including PhD programmes as well as postgraduate courses in geoinformatics, geospational technologies or information systems. Professors and former students have won ten Leibniz Prizes, the most prestigious as well as the best-funded prize in Europe, one Fields Medal and two Nobel Prizes. The WWU has also been successful in the German government's Excellence Initiative. History The university has its roots in the Münster's Jesuit College (''Jesuiten-Kolleg Münster' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
