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Org 12962
ORG-12962 is a pyridinylpiperazine drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes. It was developed as a potential anti-anxiety drug, but was discontinued from human trials after tests in a public speaking challenge showed that its anti-anxiety effects were accompanied by side effects such as dizziness and a "spacey" feeling, which were attributed to poor selectivity ''in vivo'' over the hallucinogenic 5-HT2A receptor. See also * 2C-B-PP * 2,3-Dichlorophenylpiperazine * 3-Chloro-4-fluorophenylpiperazine * CPD-1 * ORG-37684 * Quipazine Quipazine, also known as 1-(2-quinolinyl)piperazine (2-QP), is a serotonin, serotonergic drug of the arylpiperazine family and an structural analog, analogue of 1-(2-pyridinyl)piperazine which is used in scientific research. It was first describ ... References Chloropyridines 1-Piperazinyl compounds Psychedelic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyridinylpiperazine
1-(2-Pyridinyl)piperazine is a chemical compound and piperazine derivative. Some derivatives of this substance are known to act as potent and selective α2-adrenergic receptor antagonists, such as 1-(3-fluoro-2-pyridinyl)piperazine. A few pyridinylpiperazine derivatives are drugs, including: * Azaperone — antipsychotic * Atevirdine — antiretroviral * Delavirdine — antiretroviral * Mirtazapine — antidepressant See also * Diphenylmethylpiperazine * Benzylpiperazine * Phenylpiperazine * Pyrimidinylpiperazine 1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine chemical derivative, derivative. It is known to act as an receptor antagonist, antagonist of the α2-adrenergic, α2-adrenergic receptor (Ki = 7.3–40 nM) and ... References 1-Piperazinyl compounds 2-Pyridyl compounds {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5HT2A Receptor
The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and functions as a G protein-coupled receptor (GPCR). It is a cell surface receptor that activates multiple intracellular signalling cascades. Like all 5-HT2 receptors, the 5-HT2A receptor is coupled to the Gq/G11 signaling pathway. It is the primary excitatory receptor subtype among the serotonin-responsive GPCRs. The 5-HT2A receptor was initially noted for its central role as the primary target of serotonergic psychedelic drugs such as LSD and psilocybin mushrooms. It later regained research prominence when found to mediate, at least in part, the effects of many antipsychotic drugs, particularly atypical antipsychotics. Downregulation of post-synaptic 5-HT2A receptors is an adaptive response triggered by chronic administration of selective serotonin reuptake inhibitors (SSRIs) and atypical antipsychotics. Elevated 5-HT2A receptor density has been observed in suicid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychedelic Arylpiperazines
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic hallucinogens or serotonergic hallucinogens, the term ''psychedelic'' is sometimes used more broadly to include various other types of hallucinogens as well, such as those which are atypical or adjacent to psychedelia like salvia and MDMA, respectively. Classic psychedelics generally cause specific psychological, visual, and auditory changes, and oftentimes a substantially altered state of consciousness. They have had the largest influence on science and culture, and include mescaline, LSD, psilocybin, and DMT. There are a large number of both naturally occurring and synthetic serotonergic psychedelics. Most psychedelic drugs fall into one of the three families of chemical compounds: tryptamines, phenethylamines, or lysergamides. They produce the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chloropyridines
Chloropyridines are a group of aryl chlorides consisting of a pyridine ring with chlorine atoms as substituents. Chloropyridines include: *2-Chloropyridine *3-Chloropyridine *4-Chloropyridine *2,6-Dichloropyridine Production Direct halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine. 2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride. Uses Chloropyridines are important intermediates to pharmaceuticals and agrochemicals. A major use of 2-chloropyridine is the production of production of the fungicide pyrithione. Reaction of 4-chloropyridine with thioglycolic acid gives pyridylmercaptoacetic acid, a step in the production of cephalosporin antibiotics. See also *Bromopyridine References {{set index Chloropyridines, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quipazine
Quipazine, also known as 1-(2-quinolinyl)piperazine (2-QP), is a serotonin, serotonergic drug of the arylpiperazine family and an structural analog, analogue of 1-(2-pyridinyl)piperazine which is used in scientific research. It was first described in the 1960s and was originally intended as an antidepressant but was never developed or marketed for medical use. The effects of quipazine in humans include nausea, vomiting, gastrointestinal disturbances, diarrhea, and, at higher doses, psychedelic drug, psychedelic effects. Quipazine may represent the prototype of a novel structural class of psychedelic drugs. Effects The effects and side effects of quipazine in humans have been described. At a dose of 25mg oral administration, orally, they included nausea, flatulence, gastrointestinal discomfort, and diarrhea, with no LSD-like subjective effects. Higher doses were not assessed due to serotonin 5-HT3 receptor, 5-HT3 receptor-mediated side effects of nausea and gastrointestinal disord ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ORG-37684
ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, including of the serotonin 5-HT2C, 5-HT2B, and 5-HT2A receptors, in that order of potency. It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans. ORG-37684 produces the head-twitch response, a behavioral proxy of psychedelic effects, and hence may be hallucinogenic in humans. See also * Phenoxyethylamine * CT-4719 * ORG-12962 * Quipazine Quipazine, also known as 1-(2-quinolinyl)piperazine (2-QP), is a serotonin, serotonergic drug of the arylpiperazine family and an structural analog, analogue of 1-(2-pyridinyl)piperazine which is used in scientific research. It was first describ ... References 5-HT2A agonists 5-HT2B agonists 5-HT2C agonists Indanes Phenoxyethylamines Psychedelic drugs Pyrrolidines Serotonin receptor agonists {{gastrointestinal-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CPD-1
CPD-1 (LS-193743) is a drug with a benzofuranyl piperazine structure, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity and full agonist efficacy at the 5-HT2C subtype, and lower affinity and partial agonist action at the 5-HT2A and 5-HT2B subtypes. See also * DEIMDHPCA * 2,3-Dichlorophenylpiperazine * 3-Chloro-4-fluorophenylpiperazine * 2C-B-PP * ORG-12962 * TFMFly * TFMPP 3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the phenylpiperazine chemical class and is a substituted piperazine. Usually in combination with benzylpiperazine (BZP) and other structural analog, analogues, it is sold as an ... References Serotonin receptor agonists Trifluoromethyl compounds Benzofurans Piperazines {{psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-Chloro-4-fluorophenylpiperazine
3-Chloro-4-fluorophenylpiperazine (3,4-CFP, Kleferein) is a psychoactive drug of the phenylpiperazine class. It has been sold as a designer drug, first being identified in Poland in 2019. See also * 2,3-Dichlorophenylpiperazine * 2C-B-PP * 3C-PEP * CPD-1 * Org 12962 ORG-12962 is a pyridinylpiperazine drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes. It was developed as a potential anti-an ... References {{DEFAULTSORT:Chloro-4-fluorophenylpiperazine, 3- Chlorobenzene derivatives Fluoroarenes Phenylpiperazines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2,3-Dichlorophenylpiperazine
2,3-Dichlorophenylpiperazine (2,3-DCPP or DCPP) is a chemical compound from the phenylpiperazine family. It is both a precursor in the synthesis of aripiprazole and one of its metabolites. It is unclear whether 2,3-DCPP is pharmacologically active as a serotonin receptor agonist similar to its close analogue 3-chlorophenylpiperazine (''m''CPP), though it has been shown to act as a partial agonist of the dopamine D2 and D3 receptors. Legality 2,3-DCPP has been made illegal in Japan and Hungary after having been identified in seized designer drug samples. List of derivatives #Aripiprazole #Cariprazine #BAK 2-66 # Brilaroxazine (formally RP5063) #FAUC-365 74432-66-1#CJB-090 2xHCl 95584-40-0#NGB 2849 89061-11-8#NGB 2904 Fb: 89061-11-8HCl: 89060-98-8br>PG-010372xHCl: 75599-62-9#PG648Aripiptranyl(Abilifarnate) #PGX-2000001 #So-calleR-22ref name="pmid22632094"/> #So-calleJJC 7−065ref name="pmid22632094"/>R-PG-648 Positional Isomer The positional isomer 3,4-dichlorophenylpip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-B-PP
2,5-dimethoxy-4-bromophenylpiperazine (2C-B-PP) is a drug of the phenylpiperazine class. It acts as an agonist at serotonin receptor 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in multiple tissues including the central and peripheral nervous systems. They mediate both ex ...s, and in studies on rats substituted for the psychedelic amphetamine derivative DOM with around 1/10 the potency but similar rates of stimulus-appropriate responding at the highest dose. See also * 2C-B-BZP * 2C-B-aminorex * 2C-B-morpholine * 3-Chloro-4-fluorophenylpiperazine * CPD-1 * ORG-12962 * Quipazine * Substituted piperazine References {{Piperazines Bromobenzene derivatives Phenylpiperazines 1-Piperazinyl compounds Psychedelic arylpiperazines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and Signal_transduction, transduce signals that may be integrated into biological systems. These signals are typically chemical messengers which bind to a receptor and produce physiological responses, such as a change in the electrophysiology, electrical activity of a cell. For example, GABA, an inhibitory neurotransmitter, inhibits electrical activity of neurons by binding to GABAA receptor, GABA receptors. There are three main ways the action of the receptor can be classified: relay of signal, amplification, or integration. Relaying sends the signal onward, amplification increases the effect of a single ligand (biochemistry), ligand, and integration allows the signal to be incorporated into another biochemical pathway. Receptor proteins can be classified by their location. Cell surface receptors, also known as transmembrane receptors, include ligand-gated ion channels, G prote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
