|
3-Chloro-4-fluorophenylpiperazine
3-Chloro-4-fluorophenylpiperazine (3,4-CFP, Kleferein) is a psychoactive drug of the phenylpiperazine class. It has been sold as a designer drug, first being identified in Poland in 2019. See also * 2,3-Dichlorophenylpiperazine * 2C-B-PP * 3C-PEP * CPD-1 * Org 12962 ORG-12962 is a pyridinylpiperazine drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes. It was developed as a potential anti-an ... References {{DEFAULTSORT:Chloro-4-fluorophenylpiperazine, 3- Chlorobenzene derivatives Fluoroarenes Phenylpiperazines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-B-PP
2,5-dimethoxy-4-bromophenylpiperazine (2C-B-PP) is a drug of the phenylpiperazine class. It acts as an agonist at serotonin receptor 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in multiple tissues including the central and peripheral nervous systems. They mediate both ex ...s, and in studies on rats substituted for the psychedelic amphetamine derivative DOM with around 1/10 the potency but similar rates of stimulus-appropriate responding at the highest dose. See also * 2C-B-BZP * 2C-B-aminorex * 2C-B-morpholine * 3-Chloro-4-fluorophenylpiperazine * CPD-1 * ORG-12962 * Quipazine * Substituted piperazine References {{Piperazines Bromobenzene derivatives Phenylpiperazines 1-Piperazinyl compounds Psychedelic arylpiperazines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CPD-1
CPD-1 (LS-193743) is a drug with a benzofuranyl piperazine structure, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity and full agonist efficacy at the 5-HT2C subtype, and lower affinity and partial agonist action at the 5-HT2A and 5-HT2B subtypes. See also * DEIMDHPCA * 2,3-Dichlorophenylpiperazine * 3-Chloro-4-fluorophenylpiperazine * 2C-B-PP * ORG-12962 * TFMFly * TFMPP 3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the phenylpiperazine chemical class and is a substituted piperazine. Usually in combination with benzylpiperazine (BZP) and other structural analog, analogues, it is sold as an ... References Serotonin receptor agonists Trifluoromethyl compounds Benzofurans Piperazines {{psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Org 12962
ORG-12962 is a pyridinylpiperazine drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes. It was developed as a potential anti-anxiety drug, but was discontinued from human trials after tests in a public speaking challenge showed that its anti-anxiety effects were accompanied by side effects such as dizziness and a "spacey" feeling, which were attributed to poor selectivity ''in vivo'' over the hallucinogenic 5-HT2A receptor. See also * 2C-B-PP * 2,3-Dichlorophenylpiperazine * 3-Chloro-4-fluorophenylpiperazine * CPD-1 * ORG-37684 * Quipazine Quipazine, also known as 1-(2-quinolinyl)piperazine (2-QP), is a serotonin, serotonergic drug of the arylpiperazine family and an structural analog, analogue of 1-(2-pyridinyl)piperazine which is used in scientific research. It was first describ ... References Chloropyridines 1-Piperazinyl compounds Psychedelic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrochloride
In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine). An alternative name is chlorhydrate, which comes from French. An archaic alternative name is muriate, derived from hydrochloric acid's ancient name: muriatic acid. Uses Converting amines into their hydrochlorides is a common way to improve their water solubility, which can be desirable for substances used in medications. The European Pharmacopoeia lists more than 200 hydrochlorides as active ingredients in medications. These hydrochlorides, compared to free bases, may more readily dissolve in the gastrointestinal tract and be absorbed into the bloodstream more quickly. Additionally, many hydrochlorides of amines have a longer shelf-life than their respective free bases. Amine hydrochlorides represent latent forms of a more reactive free base. In this regard, formation of an amine hydrochloride confers protection ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychoactive Drug
A psychoactive drug, psychopharmaceutical, mind-altering drug, consciousness-altering drug, psychoactive substance, or psychotropic substance is a chemical substance that alters psychological functioning by modulating central nervous system activity. Psychoactive and psychotropic drugs both affect the brain, with psychotropics sometimes referring to psychiatric drugs or high-abuse substances, while “drug” can have negative connotations. Designer drug, Novel psychoactive substances are designer drugs made to mimic illegal ones and bypass laws. Psychoactive drug use dates back to prehistory for medicinal and consciousness-altering purposes, with evidence of widespread cultural use. Many animals intentionally consume psychoactive substances, and some traditional legends suggest animals first introduced humans to their use. Psychoactive substances are used across cultures for purposes ranging from medicinal and therapeutic treatment of Mental disorder, mental disorders and pain, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenylpiperazine
1-Phenylpiperazine (1-PP or PP) is a simple chemical compound and drug featuring a phenyl group bound to a piperazine ring. The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class. It is a rigid analogue of amphetamine. Similarly to amphetamine, 1-PP is a monoamine releasing agent, with values for monoamine release of 186nM for norepinephrine, 880nM for serotonin, and 2,530nM for dopamine. Based on the preceding values, it is about 4.7-fold less potent in releasing serotonin than norepinephrine and about 13.6-fold less potent in releasing dopamine than norepinephrine. Hence, 1-PP is a modestly selective norepinephrine releasing agent (NRA), or could alternatively be thought of as an imbalanced serotonin–norepinephrine releasing agent (SNRA) or serotonin–norepinephrine–dopamine releasing agent (SNDRA). Other homologues and rigid analogues of amphetamine besides 1-PP include 2-aminotetralin (2-AT), 2-amino-1,2-dihydrona ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Designer Drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union, Australia, and New Zealand, as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids. Some of these designer drugs were originally synthesized by academic or industrial researchers in an effort to discover more potent derivatives with fewer side effects and shorter duration (and possibly also because it is easier to apply for patents for new molecules) and were later co-opted for recreational use. Other designer drugs were prepared for the first time in clandestine laboratories. Because the efficacy and safety of these substances have not been thoroughly evaluated in animal and human tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2,3-Dichlorophenylpiperazine
2,3-Dichlorophenylpiperazine (2,3-DCPP or DCPP) is a chemical compound from the phenylpiperazine family. It is both a precursor in the synthesis of aripiprazole and one of its metabolites. It is unclear whether 2,3-DCPP is pharmacologically active as a serotonin receptor agonist similar to its close analogue 3-chlorophenylpiperazine (''m''CPP), though it has been shown to act as a partial agonist of the dopamine D2 and D3 receptors. Legality 2,3-DCPP has been made illegal in Japan and Hungary after having been identified in seized designer drug samples. List of derivatives #Aripiprazole #Cariprazine #BAK 2-66 # Brilaroxazine (formally RP5063) #FAUC-365 74432-66-1#CJB-090 2xHCl 95584-40-0#NGB 2849 89061-11-8#NGB 2904 Fb: 89061-11-8HCl: 89060-98-8br>PG-010372xHCl: 75599-62-9#PG648Aripiptranyl(Abilifarnate) #PGX-2000001 #So-calleR-22ref name="pmid22632094"/> #So-calleJJC 7−065ref name="pmid22632094"/>R-PG-648 Positional Isomer The positional isomer 3,4-dichlorophenylpip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3C-PEP
1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (3C-PEP) is a designer drug of the piperazine class of chemical substances. 3C-PEP is related to ''meta''-cholorophenylpiperazine (mCPP) and phenethylamine which can be thought of as mCPP having a phenylethyl group attached to the nitrogen atom at its 4-position. It was first described in 1994 in a patent disclosing a series of piperazine compounds as sigma receptor ligands. Later, it was discovered to be a highly potent dopamine reuptake inhibitor. Pharmacology 3C-PEP is one of the most potent dopamine transporter (DAT) ligands reported to date. It is highly selective for the dopamine transporter (dissociation constant K = 0.04 nM) with relatively low affinity for the closely related norepinephrine transporter (NET, K = 1107 nM ) and the serotonin transporter (SERT, K = 802 nM). In addition, the compound has lower (or no) affinity for the PCP/NMDA receptor (K > 10000 nM), D2-like receptors (K = 327 nM), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chlorobenzene Derivatives
Chlorobenzene (abbreviated PhCl) is an aryl chloride and the simplest of the chlorobenzenes, consisting of a benzene ring substituted with one chlorine atom. Its chemical formula is C6H5Cl. This colorless, flammable liquid is a common solvent and a widely used intermediate in the manufacture of other chemicals. Uses The major use of chlorobenzene is as a precursor for further intermediates such as nitrophenols, nitroanisole, chloroaniline, and phenylenediamines, which are used in the production of herbicides, dyestuffs, chemicals for rubber, and pharmaceuticals. It is also used as a high-boiling solvent in industrial and laboratory applications, for materials such as oils, waxes, resins, and rubber. Chlorobenzene is nitrated on a large scale to give a mixture of 2-nitrochlorobenzene and 4-nitrochlorobenzene, which are separated and used as intermediates in production of other chemicals. These mononitrochlorobenzenes are converted to related 2-nitrophenol, 2-nitroanisole, b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fluoroarenes
In organic chemistry, an aryl halide (also known as a haloarene) is an aromatic compound in which one or more hydrogen atoms directly bonded to an aromatic ring are replaced by a halide ion (such as fluorine F''−'', chlorine Cl−1,−3,−5, bromine Br−1, or iodine I−). Aryl halides are distinct from haloalkanes (alkyl halides) due to significant differences in their methods of preparation, chemical reactivity, and physical properties. The most common and important members of this class are aryl chlorides, but the group encompasses a wide range of derivatives with diverse applications in organic synthesis, pharmaceuticals, and materials science. Classification according to halide Aryl fluorides Aryl fluorides are used as synthetic intermediates, e.g. for the preparation of pharmaceuticals, pesticides, and liquid crystals. The conversion of diazonium salts is a well established route to aryl fluorides. Thus, anilines are precursors to aryl fluorides. In the classic Schiemann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
