|
National Toxicology Program
The National Toxicology Program (NTP) is an inter-agency program run by the United States Department of Health and Human Services to coordinate, evaluate, and report on toxicology within public agencies. The National Toxicology Program is headquartered at the National Institute of Environmental Health Sciences (NIEHS). The NIEHS Director, currently Richard Woychik, also concurrently serves as NTP Director. History The program was established in 1978 by Joseph A. Califano Jr., then the United States Secretary of Health, Education, and Welfare (today known as the Secretary of Health and Human Services). The program arose from congressional concerns about the health effects of chemical agents in the environment. In October 1981, Secretary Richard S. Schwiker granted permanent status to the program. Interagency Center for the Evaluation of Alternative Toxicological Methods The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) supports the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Department Of Health And Human Services
The United States Department of Health and Human Services (HHS) is a cabinet-level executive branch department of the US federal government created to protect the health of the US people and providing essential human services. Its motto is "Improving the health, safety, and well-being of America". Before the separate federal Department of Education was created in 1979, it was called the Department of Health, Education, and Welfare (HEW). HHS is administered by the secretary of health and human services, who is appointed by the president with the advice and consent of the United States Senate. The United States Public Health Service Commissioned Corps, the uniformed service of the PHS, is led by the surgeon general who is responsible for addressing matters concerning public health as authorized by the secretary or by the assistant secretary for health in addition to his or her primary mission of administering the Commissioned Corps. History Federal Security Agency ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Environmental Health Sciences
The National Institute of Environmental Health Sciences (NIEHS) conducts research into the effects of the environment on human disease, as one of the 27 institutes and centers of the National Institutes of Health (NIH). It is located in the Research Triangle Park in North Carolina, and is the only primary division of the NIH located outside of the Washington metropolitan area. As an institute of the National Institutes of Health, the NIEHS supports environmental health research with the mission of reducing environmental disease, advancing basic, environmental health and clinical science, and increasing the availability of researcher and worker training. Constitution The National Institute of Environmental Health Sciences is a part of the National Institutes of Health, which is in turn a part of the United States Department of Health and Human Services (HHS). The mission of the NIEHS is to "reduce the burden of human illness and disability by understanding how the environment ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard Woychik
Richard is a male given name. It originates, via Old French, from Old Frankish and is a compound of the words descending from Proto-Germanic language">Proto-Germanic ''*rīk-'' 'ruler, leader, king' and ''*hardu-'' 'strong, brave, hardy', and it therefore means 'strong in rule'. Nicknames include "Richie", " Dick", "Dickon", " Dickie", "Rich", "Rick", "Rico (name), Rico", " Ricky", and more. Richard is a common English (the name was introduced into England by the Normans), German and French male name. It's also used in many more languages, particularly Germanic, such as Norwegian, Danish, Swedish, Icelandic, and Dutch, as well as other languages including Irish, Scottish, Welsh and Finnish. Richard is cognate with variants of the name in other European languages, such as the Swedish "Rickard", the Portuguese and Spanish "Ricardo" and the Italian "Riccardo" (see comprehensive variant list below). People named Richard Multiple people with the same name * Richard Andersen (d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Secretary Of Health, Education, And Welfare
The United States secretary of health and human services is the head of the United States Department of Health and Human Services, and serves as the principal advisor to the president of the United States on all health matters. The secretary is a member of the United States Cabinet. Robert F. Kennedy Jr. is the incumbent secretary of health and human services, having held the position since February 13, 2025. The office was formerly known as the secretary of health, education, and welfare. In 1980, the Department of Health, Education, and Welfare was renamed to Department of Health and Human Services, and its education functions and Rehabilitation Services Administration were transferred to the new United States Department of Education. Patricia Roberts Harris headed the department before and after it was renamed. Nominations to the office are referred to the Health, Education, Labor and Pensions Committee and the United States Senate Committee on Finance, which has jurisdi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alternatives To Animal Testing
Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals. There is widespread agreement that a reduction in the number of animals used and the refinement of testing to reduce suffering should be important goals for the industries involved. Two major alternatives to ''in vivo'' animal testing are ''in vitro'' cell culture techniques and ''in silico'' computer simulation; however, some claim they are not true alternatives because simulations use data from prior animal experiments and cell cultures often require animal derived products, such as blood plasma, serum or cells. Others say that they cannot replace animals completely as they are unlikely to ever provide enough information about the complex interactions of living systems. Other alternatives include the use of humans for skin irritancy tests and donated human blood for pyrogenicity studies. Another alternative is microdosing, in which the basic behaviour of dru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diplomate American Board Of Toxicology
A diplomat (from ; romanized ''diploma'') is a person appointed by a state, intergovernmental, or nongovernmental institution to conduct diplomacy with one or more other states or international organizations. The main functions of diplomats are representation and protection of the interests and nationals of the sending state; initiation and facilitation of strategic agreements, treaties and conventions; and promotion of information, trade and commerce, technology, and friendly relations. Seasoned diplomats of international repute are used in international organizations (for example, the United Nations, the world's largest diplomatic forum) as well as multinational companies for their experience in management and negotiating skills. Diplomats are members of foreign services and diplomatic corps of various nations of the world. The sending state is required to get the consent of the receiving state for a person proposed to serve in key diplomatic positions such as an ambassador, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interagency Coordinating Committee On The Validation Of Alternative Methods
The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) coordinates U.S. federal government evaluation of new, revised, and alternative test methods. Alternative methods are methods for safety testing of chemicals and chemical products that use fewer or no animals or that minimize or prevent animal pain and distress. Establishment of ICCVAM ThICCVAM Authorization Act of 2000created ICCVAM to "establish, wherever feasible, guidelines, recommendations, and regulations that promote the regulatory acceptance of new or revised scientifically valid safety testing methods that protect human and animal health and the environment while reducing, refining, and replacing animal tests and ensuring human safety and product effectiveness". This Act addressed directives in the NIH Revitalization Act of 1993 requiring that the National Institute of Environmental Health Sciences (NIEHS) establish criteria for the validation and regulatory acceptance of alternativ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tox21
Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the ''TOX'' gene. TOX drives T-cell exhaustion and plays a role in innate lymphoid cell development. Structure The TOX gene encodes a protein that belongs to a large superfamily of chromatin associated proteins that share an approximately 75 amino acid DNA binding motif, the HMG (high mobility group)-box (named after that found in the canonical member of the family, high mobility group protein 1). Some high mobility group (HMG) box proteins (e.g., LEF1) contain a single HMG box motif and bind DNA in a sequence-specific manner, while other members of this family (e.g., HMGB1) have multiple HMG boxes and bind DNA in a sequence-independent but structure-dependent manner. While TOX has a single HMG-box motif, it is predicted to bind DNA in a sequence-independent manner. TOX subfamily TOX is a member of a small subfamily of proteins (TOX2, TOX3, and TOX4) that share almo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Society Of Toxicology
The Society of Toxicology (SOT) is a learned society (professional association) based in the United States that supports scientific inquiry in the field of toxicology. Goals The SOT is committed to creating a safer and healthier world by advancing the science of toxicology. The Society promotes the acquisition and utilization of knowledge in toxicology, aids in the protection of public health, and facilitates disciplines. SOT's definition of toxicology is 'the study of the adverse effects of chemical, physical or biological agents on living organisms and the ecosystem, including the prevention and amelioration of such adverse effects.' The society organizes an annual meeting (usually in the early spring) and several smaller colloquia via its special interest sections and groups. It publishes the journal ''Toxicological Sciences'', as well as public position papers and guidelines on conflicts of interest A conflict of interest (COI) is a situation in which a person or organi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World Congress On Alternatives And Animal Use In The Life Sciences
The world is the totality of entities, the whole of reality, or everything that exists. The nature of the world has been conceptualized differently in different fields. Some conceptions see the world as unique, while others talk of a "plurality of worlds". Some treat the world as one simple object, while others analyze the world as a complex made up of parts. In scientific cosmology, the world or universe is commonly defined as "the totality of all space and time; all that is, has been, and will be". Theories of modality talk of possible worlds as complete and consistent ways how things could have been. Phenomenology, starting from the horizon of co-given objects present in the periphery of every experience, defines the world as the biggest horizon, or the "horizon of all horizons". In philosophy of mind, the world is contrasted with the mind as that which is represented by the mind. Theology conceptualizes the world in relation to God, for example, as God's creation, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carcinogens
A carcinogen () is any agent that promotes the development of cancer. Carcinogens can include synthetic chemicals, naturally occurring substances, physical agents such as ionizing and non-ionizing radiation, and biologic agents such as viruses and bacteria. Most carcinogens act by creating mutations in DNA that disrupt a cell's normal processes for regulating growth, leading to uncontrolled cellular proliferation. This occurs when the cell's DNA repair processes fail to identify DNA damage allowing the defect to be passed down to daughter cells. The damage accumulates over time. This is typically a multi-step process during which the regulatory mechanisms within the cell are gradually dismantled allowing for unchecked cellular division. The specific mechanisms for carcinogenic activity is unique to each agent and cell type. Carcinogens can be broadly categorized, however, as activation-dependent and activation-independent which relate to the agent's ability to engage direc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trichloroethylene
Trichloroethylene (TCE) is an organochloride with the formula C2HCl3, commonly used as an industrial metal-degreasing solvent. It is a clear, colourless, non-flammable, volatile liquid with a chloroform-like pleasant mild smell and sweet taste.Trichloroethylene (TCE) on ATSDR Its name is trichloroethene. Trichloroethylene has been sold under a variety of trade names. Industrial abbreviations include trichlor, Trike, Tricky and tri. Under the trade names Trimar and Trilene, it was used as a [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
