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Michael I. Miller
Michael Ira Miller (born 1955) is an American-born biomedical engineer and data scientist, and the Bessie Darling Massey Professor and Director of the Johns Hopkins University Department of Biomedical Engineering. He worked with Ulf Grenander in the field of Computational Anatomy as it pertains to neuroscience, specializing in mapping the brain under various states of health and disease by applying data derived from medical imaging. Miller is the director of the Johns Hopkins Center for Imaging Science, Whiting School of Engineering and codirector of Johns Hopkins Kavli Neuroscience Discovery Institute. Miller is also a Johns Hopkins University Gilman Scholar. Biography Miller received his Bachelor of Engineering from The State University of New York at Stony Brook in 1976, followed by a Master of Science degree in 1978 and PhD in biomedical engineering in 1983, both from the Johns Hopkins University. He completed postdoctoral research on medical imaging at Washington Univers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brooklyn
Brooklyn () is a borough of New York City, coextensive with Kings County, in the U.S. state of New York (state), New York. Kings County is the most populous Administrative divisions of New York (state)#County, county in the State of New York, and the County statistics of the United States#Most densely populated, second-most densely populated county in the United States, behind New York County (Manhattan). Brooklyn is also New York City's most populous borough,2010 Gazetteer for New York State United States Census Bureau. Retrieved September 18, 2016. with 2,736,074 residents in 2020. Named after the Dutch village of Breukelen, Brooklyn is located on the western portion of Long Island and shares a border with the borough of Queens. It has several bridge an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
State University Of New York At Stony Brook
Stony Brook University (SBU), officially the State University of New York at Stony Brook, is a public research university in Stony Brook, New York. Along with the University at Buffalo, it is one of the State University of New York system's two flagship institutions. Its campus consists of 213 buildings on over of land in Suffolk County and it is the largest public university (by area) in the state of New York. Opened in 1957 in Oyster Bay as the State University College on Long Island, the institution moved to Stony Brook in 1962. In 2001, Stony Brook was elected to the Association of American Universities, a selective group of major research universities in North America. It is also a member of the larger Universities Research Association. It is classified among "R1: Doctoral Universities – Very high research activity". Stony Brook University, in partnership with Battelle, manages Brookhaven National Laboratory, a national laboratory of the United States Departme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sieve Estimator
In statistics, sieve estimators are a class of non-parametric estimators which use progressively more complex models to estimate an unknown high-dimensional function as more data becomes available, with the aim of asymptotically reducing error towards zero as the amount of data increases. This method is generally attributed to Ulf Grenander. Method of sieves in Positron emission tomography Sieve estimators have been used extensively for estimating density functions in high-dimensional spaces such as in Positron emission tomography(PET). The first exploitation of Sieves in PET for solving the maximum-likelihood Positron emission tomography#Image reconstruction problem was by Donald Snyder and Michael Miller, where they stabilized the time-of-flight PET problem originally solved by Shepp and Vardi. Shepp and Vardi's introduction of Maximum-likelihood estimators in emission tomography exploited the use of the Expectation-Maximization algorithm, which as it ascended towards the maxi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Likelihood Function
The likelihood function (often simply called the likelihood) represents the probability of random variable realizations conditional on particular values of the statistical parameters. Thus, when evaluated on a given sample, the likelihood function indicates which parameter values are more ''likely'' than others, in the sense that they would have made the observed data more probable. Consequently, the likelihood is often written as \mathcal(\theta\mid X) instead of P(X \mid \theta), to emphasize that it is to be understood as a function of the parameters \theta instead of the random variable X. In maximum likelihood estimation, the arg max of the likelihood function serves as a point estimate for \theta, while local curvature (approximated by the likelihood's Hessian matrix) indicates the estimate's precision. Meanwhile in Bayesian statistics, parameter estimates are derived from the converse of the likelihood, the so-called posterior probability, which is calculated via Baye ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michel Ter-Pogossian
Michel Matthew Ter-Pogossian (April 21, 1925June 19, 1996) was an American medical physicist. He was professor of radiology at the Washington University School of Medicine for over 30 years. A pioneer in nuclear medicine, he is best known for his research on the positron emission tomography (PET). He is considered one of its creators and often referred to as the "father of PET." Early life Ter-Pogossian was born on April 21, 1925 in Berlin to Armenian parents from the Ottoman Empire that escaped the Armenian genocide. He was the only child. His family later moved to France, where Ter-Pogossian grew up. He developed an early interest in science and experimented with toy physics and chemistry kits as a child. Ter-Pogossian attended the University of Paris, from which he received his bachelor's degree in mathematics in 1942 or 1943. He subsequently studied at the Institute of Radium under Irène Joliot-Curie, graduating in 1946. He was active in the French Resistance during World Wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iterative Reconstruction
Iterative reconstruction refers to iterative algorithms used to reconstruct 2D and 3D images in certain imaging techniques. For example, in computed tomography an image must be reconstructed from projections of an object. Here, iterative reconstruction techniques are usually a better, but computationally more expensive alternative to the common filtered back projection (FBP) method, which directly calculates the image in a single reconstruction step.Herman, G. T.Fundamentals of computerized tomography: Image reconstruction from projection 2nd edition, Springer, 2009 In recent research works, scientists have shown that extremely fast computations and massive parallelism is possible for iterative reconstruction, which makes iterative reconstruction practical for commercialization. Basic concepts The reconstruction of an image from the acquired data is an inverse problem. Often, it is not possible to exactly solve the inverse problem directly. In this case, a direct algorithm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Positron Emission Tomography
Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example: * Fluorodeoxyglucose ( 18F">sup>18FDG or FDG) is commonly used to detect cancer; * 18Fodium fluoride">sup>18Fodium fluoride (Na18F) is widely used for detecting bone formation; * Oxygen-15 (15O) is sometimes used to measure blood flow. PET is a common imaging technique, a medical scintillography technique used in nuclear medicine. A radiopharmaceutical – a radioisotope attached to a drug – is injected into the body as a radioactive tracer, tracer. When the radiopharmaceutical undergoes beta plus decay, a positron is emitted, and when the positron interacts with an or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Imaging
Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues ( physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging. Measurement and recording techniques that are not primarily designed to produce images, such as electroencephalography (EEG), magnetoencephalography (MEG), electrocardiography (ECG), and others, represent other technologies that produce data susceptible to representation as a parameter graph versus time or maps that contain data about the measurement ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain Mapping
Brain mapping is a set of neuroscience techniques predicated on the mapping of (biological) quantities or properties onto spatial representations of the (human or non-human) brain resulting in maps. According to the definition established in 2013 by Society for Brain Mapping and Therapeutics (SBMT), brain mapping is specifically defined, in summary, as the study of the anatomy and function of the brain and spinal cord through the use of imaging, immunohistochemistry, molecular & optogenetics, stem cell and cellular biology, engineering, neurophysiology and nanotechnology. Overview All neuroimaging is considered part of brain mapping. Brain mapping can be conceived as a higher form of neuroimaging, producing brain images supplemented by the result of additional (imaging or non-imaging) data processing or analysis, such as maps projecting (measures of) behavior onto brain regions (see fMRI). One such map, called a connectogram, depicts cortical regions around a c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cochlear Implants
A cochlear implant (CI) is a surgically implanted neuroprosthesis that provides a person who has moderate-to-profound sensorineural hearing loss with sound perception. With the help of therapy, cochlear implants may allow for improved speech understanding in both quiet and noisy environments. A CI bypasses acoustic hearing by direct electrical stimulation of the auditory nerve. Through everyday listening and auditory training, cochlear implants allow both children and adults to learn to interpret those signals as speech and sound. The implant has two main components. The outside component is generally worn behind the ear, but could also be attached to clothing, for example, in young children. This component, the sound processor, contains microphones, electronics that include digital signal processor (DSP) chips, battery, and a coil that transmits a signal to the implant across the skin. The inside component, the actual implant, has a coil to receive signals, electronics, and an a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cochlear Nerve
The cochlear nerve (also auditory nerve or acoustic nerve) is one of two parts of the vestibulocochlear nerve, a cranial nerve present in amniotes, the other part being the vestibular nerve. The cochlear nerve carries auditory sensory information from the cochlea of the inner ear directly to the brain. The other portion of the vestibulocochlear nerve is the vestibular nerve, which carries spatial orientation information to the brain from the semicircular canals, also known as semicircular ducts. Anatomy and connections In terms of anatomy, an auditory nerve fiber is either bipolar or unipolar, with its distal projection being called the peripheral process, and its proximal projection being called the axon; these two projections are also known as the "peripheral axon" and the "central axon", respectively. The peripheral process is sometimes referred to as a dendrite, although that term is somewhat inaccurate. Unlike the typical dendrite, the peripheral process generates and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neural Coding
Neural coding (or Neural representation) is a neuroscience field concerned with characterising the hypothetical relationship between the Stimulus (physiology), stimulus and the individual or Neuronal ensemble, ensemble neuronal responses and the relationship among the Electrophysiology, electrical activity of the neurons in the ensemble. Based on the theory that sensory and other information is represented in the brain by Biological neural network, networks of neurons, it is thought that neurons can encode both Digital data, digital and analog signal, analog information. Overview Neurons are remarkable among the cells (biology), cells of the body in their ability to propagate signals rapidly over large distances. They do this by generating characteristic electrical pulses called action potentials: voltage spikes that can travel down axons. Sensory neurons change their activities by firing sequences of action potentials in various temporal patterns, with the presence of external se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
