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Michel Ter-Pogossian
Michel Matthew Ter-Pogossian (April 21, 1925June 19, 1996) was an American medical physicist. He was professor of radiology at the Washington University School of Medicine for over 30 years. A pioneer in nuclear medicine, he is best known for his research on the positron emission tomography (PET). He is considered one of its creators and often referred to as the "father of PET." Early life Ter-Pogossian was born on April 21, 1925, in Berlin to Armenian parents from the Ottoman Empire who escaped the Armenian genocide. He was the only child. His family later moved to France, where Ter-Pogossian grew up. He developed an early interest in science and experimented with toy physics and chemistry kits as a child. Ter-Pogossian attended the University of Paris, from which he received his bachelor's degree in mathematics in 1942 or 1943. He subsequently studied at the Institute of Radium under Irène Joliot-Curie, graduating in 1946. He was active in the French Resistance during World Wa ...
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Berlin
Berlin ( ; ) is the Capital of Germany, capital and largest city of Germany, by both area and List of cities in Germany by population, population. With 3.7 million inhabitants, it has the List of cities in the European Union by population within city limits, highest population within its city limits of any city in the European Union. The city is also one of the states of Germany, being the List of German states by area, third smallest state in the country by area. Berlin is surrounded by the state of Brandenburg, and Brandenburg's capital Potsdam is nearby. The urban area of Berlin has a population of over 4.6 million and is therefore the most populous urban area in Germany. The Berlin/Brandenburg Metropolitan Region, Berlin-Brandenburg capital region has around 6.2 million inhabitants and is Germany's second-largest metropolitan region after the Rhine-Ruhr region, as well as the List of EU metropolitan areas by GDP, fifth-biggest metropolitan region by GDP in the European Union. ...
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Ottoman Empire
The Ottoman Empire (), also called the Turkish Empire, was an empire, imperial realm that controlled much of Southeast Europe, West Asia, and North Africa from the 14th to early 20th centuries; it also controlled parts of southeastern Central Europe, between the early 16th and early 18th centuries. The empire emerged from a Anatolian beyliks, ''beylik'', or principality, founded in northwestern Anatolia in by the Turkoman (ethnonym), Turkoman tribal leader Osman I. His successors Ottoman wars in Europe, conquered much of Anatolia and expanded into the Balkans by the mid-14th century, transforming their petty kingdom into a transcontinental empire. The Ottomans ended the Byzantine Empire with the Fall of Constantinople, conquest of Constantinople in 1453 by Mehmed II. With its capital at History of Istanbul#Ottoman Empire, Constantinople (modern-day Istanbul) and control over a significant portion of the Mediterranean Basin, the Ottoman Empire was at the centre of interacti ...
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Positron Emission
Positron emission, beta plus decay, or β+ decay is a subtype of radioactive decay called beta decay, in which a proton inside a radionuclide nucleus is converted into a neutron while releasing a positron and an electron neutrino (). Positron emission is mediated by the weak force. The positron is a type of beta particle (β+), the other beta particle being the electron (β−) emitted from the β− decay of a nucleus. An example of positron emission (β+ decay) is shown with magnesium-23 decaying into sodium-23: : → + + Because positron emission decreases proton number relative to neutron number, positron decay happens typically in large "proton-rich" radionuclides. Positron decay results in nuclear transmutation, changing an atom of one chemical element into an atom of an element with an atomic number that is less by one unit. Positron emission occurs extremely rarely in nature on Earth. Known instances include cosmic ray interactions and the decay of certain isotopes, ...
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Washington University Medical Center
The Washington University Medical Campus (WUMC), located in St. Louis, Missouri, is a large scale health-care-focused commercial development located in the Central West End neighborhood of St Louis. The WUMC corporate partners are Barnes-Jewish Hospital, BJC HealthCare, St. Louis Children’s Hospital, and Washington University School of Medicine. History The Washington University Medical Center was incorporated in 1962. The name changed from Washington University Medical Center to Washington University Medical Campus in 2017. The campus is located on over directly to the east of Forest Park. WUMC serves as the anchor of the Central West End community, a commercial and residential neighborhood with numerous shops, restaurants, and night spots. The Washington University Medical Center Redevelopment Corporation (WUMCRC) focuses on developing public-private partnerships that promote infrastructure and housing development in the WUMC area, including the Central West End and Fo ...
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Radioactive Tracer
A radioactive tracer, radiotracer, or radioactive label is a synthetic derivative of a natural compound in which one or more atoms have been replaced by a radionuclide (a radioactive atom). By virtue of its radioactive decay, it can be used to explore the mechanism of chemical reactions by tracing the path that the radioisotope follows from reactants to products. Radiolabeling or radiotracing is thus the radioactive form of isotopic labeling. In biological contexts, experiments that use radioisotope tracers are sometimes called radioisotope feeding experiments. Radioisotopes of hydrogen, carbon, phosphorus, sulfur, and iodine have been used extensively to trace the path of biochemical reactions. A radioactive tracer can also be used to track the distribution of a substance within a natural system such as a cell or tissue, or as a flow tracer to track fluid flow. Radioactive tracers are also used to determine the location of fractures created by hydraulic fracturing in nat ...
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Gamma Camera
A gamma camera (γ-camera), also called a scintillation camera or Anger camera, is a device used to image gamma radiation emitting radioisotopes, a technique known as scintigraphy. The applications of scintigraphy include early drug development and nuclear medical imaging to view and analyse images of the human body or the distribution of medically injected, inhaled, or ingested radionuclides emitting gamma rays. Imaging techniques Scintigraphy ("scint") is the use of gamma cameras to capture emitted radiation from internal radioisotopes to create two-dimensional images. SPECT (single photon emission computed tomography) imaging, as used in nuclear cardiac stress testing, is performed using gamma cameras. Usually one, two or three detectors or heads, are slowly rotated around the patient. Construction A gamma camera consists of one or more flat crystal planes (or detectors) optically coupled to an array of photomultiplier tubes in an assembly known as a "head", mounted ...
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Brachytherapy
Brachytherapy is a form of radiation therapy where a sealed radiation, radiation source is placed inside or next to the area requiring treatment. The word "brachytherapy" comes from the Ancient Greek, Greek word , meaning "short-distance" or "short". Brachytherapy is commonly used as an effective treatment for cervical cancer, cervical, Prostate cancer, prostate, Breast cancer, breast, Esophageal cancer, esophageal and skin cancer and can also be used to treat tumours in many other body sites. Treatment results have demonstrated that the cancer-cure rates of brachytherapy are either comparable to surgery and external beam radiotherapy (EBRT) or are improved when used in combination with these techniques. Brachytherapy can be used alone or in combination with other therapies such as surgery, EBRT and chemotherapy. Brachytherapy contrasts with unsealed source radiotherapy, in which a therapeutic radionuclide (radioisotope) is injected into the body to chemically localize to the t ...
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Radiation Therapy
Radiation therapy or radiotherapy (RT, RTx, or XRT) is a therapy, treatment using ionizing radiation, generally provided as part of treatment of cancer, cancer therapy to either kill or control the growth of malignancy, malignant cell (biology), cells. It is normally delivered by a linear particle accelerator. Radiation therapy may be cure, curative in a number of types of cancer if they are localized to one area of the body, and have not metastasis, spread to other parts. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology. A physician who practices in this subspecialty is a radiation oncologist. Radiation therapy is commonly applied to the canc ...
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Medical Imaging
Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organ (anatomy), organs and Tissue (biology), tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging. Measurement and recording techniques that are not primarily designed to produce images, such as electroencephalography (EEG), magnetoencephalography (MEG), electrocardiography (ECG), and others, represent other technologies that produce data susceptible to representation as a parameter graph versus time or maps that contain ...
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Nuclear Physics
Nuclear physics is the field of physics that studies atomic nuclei and their constituents and interactions, in addition to the study of other forms of nuclear matter. Nuclear physics should not be confused with atomic physics, which studies the atom as a whole, including its electrons. Discoveries in nuclear physics have led to applications in many fields such as nuclear power, nuclear weapons, nuclear medicine and magnetic resonance imaging, industrial and agricultural isotopes, ion implantation in materials engineering, and radiocarbon dating in geology and archaeology. Such applications are studied in the field of nuclear engineering. Particle physics evolved out of nuclear physics and the two fields are typically taught in close association. Nuclear astrophysics, the application of nuclear physics to astrophysics, is crucial in explaining the inner workings of stars and the origin of the chemical elements. History The history of nuclear physics as a discipline ...
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Research Assistant
A research assistant (RA) is a researcher employed, often on a temporary contract, by a university, research institute, or privately held organization to provide assistance in academic or private research endeavors. Research assistants work under the supervision of a principal investigator or supervisor and typically do not bear direct responsibility for the final outcomes of the research. However, in certain countries, research assistants can be the primary contributors to the research outcomes. Research assistants are commonly educated to at least degree level, and they may also be enrolled in postgraduate degree programs. In some cases, such as when pursuing a PhD, they are referred to as Doctoral Research Assistants and may also have teaching responsibilities alongside their research commitments. Undergraduate and post-doctoral level Although research assistants are typically appointed at the graduate level, there are instances where undergraduate students are also employed to ...
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Arthur Compton
Arthur Holly Compton (September 10, 1892 – March 15, 1962) was an American particle physicist who won the 1927 Nobel Prize in Physics for his discovery of the Compton effect, which demonstrated the particle nature of electromagnetic radiation. It was a sensational discovery at the time: the wave nature of light had been well-demonstrated, but the idea that light had both wave and particle properties was not easily accepted. He is also known for his leadership over the Metallurgical Laboratory at the University of Chicago during the Manhattan Project, and served as chancellor of Washington University in St. Louis from 1945 to 1953. In 1919, Compton was awarded one of the first two National Research Council Fellowships that allowed students to study abroad. He chose to go to the University of Cambridge's Cavendish Laboratory in England, where he studied the scattering and absorption of gamma rays. Further research along these lines led to the discovery of the Compton eff ...
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