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Masoprocol
Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. It is the meso form of nordihydroguaiaretic acid that is taken by mouth. The substance is being studied in the treatment of prostate cancer. Masoprocol is also called NDGA, and Actinex. Mechanism Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth. It is a lipoxygenase inhibitor Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of leukot .... References External links MedlinePlus Drug InformationActinexentry in the public domain NCI Cancer Dictionary Antineoplastic drugs Catechols {{antineoplastic-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nordihydroguaiaretic Acid
Nordihydroguaiaretic acid, informally abbreviated NDGA in research articles, is a classic lignan, a phenylpropane dimer linked by a bond between positions C8 and C8′, as opposed to a neolignan. It is a natural compound found in the creosote bush (''Larrea tridentata''). Medical properties As a lignan, it is a member of one of the major classes of phytoestrogens. While it is commonly asserted that the biological properties of lignans per sé are void, and that only the enterolignans enterodiol and enterolactone, produced from lignans by intestinal bacteria have interesting biological properties, nordihydroguaiaretic acid has antioxidant and anti-inflammatory properties in vitro or in animal models. It is a redox-type inhibitor of 5-lipoxygenase. A 1986 study involved feeding female mosquitos NDGA to test the effect on their average life span. While the usual mosquito life span was 29 days, the NDGA-fed mosquitos lived an average of 45 days—an increase of 50 percent. A 2008 s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Topical
A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. Many topical medications are epicutaneous, meaning that they are applied directly to the skin. Topical medications may also be inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a tooth. The word ''topical'' derives from Greek τοπικός ''topikos'', "of a place". Justification Topical drug delivery is a route of administering drugs via the skin to provide topical therapeutic effects. As skin is one of the largest and most superficial organs in the human body, pharmacists utilise it to deliver vari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meso Compound
A meso compound or meso isomer is a non-optically active member of a set of stereoisomers, at least two of which are optically active. This means that despite containing two or more stereocenters, the molecule is not chiral. A meso compound is "superposable" on its mirror image (not to be confused with superimposable, as any two objects can be superimposed over one another regardless of whether they are the same). Two objects can be superposed if all aspects of the objects coincide and it does not produce a "(+)" or "(-)" reading when analyzed with a polarimeter. The name is derived from the Greek ''mésos'' meaning “middle”. For example, tartaric acid can exist as any of three stereoisomers depicted below in a Fischer projection. Of the four colored pictures at the top of the diagram, the first two represent the meso compound (the 2'' R'',3'' S'' and 2'' S'',3'' R'' isomers are equivalent), followed by the optically active pair of levotartaric acid (L-(''R,R'')-(+)-tartaric ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipoxygenase Inhibitor
Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of leukotrienes is a major cause of inflammation in asthma, allergic rhinitis, and osteoarthritis. Examples of 5-LOX inhibitors include the pharmaceutical drugs meclofenamate sodium, zileuton and the natural products myxochelins/pseudochelin as well as nordihydroguaiaretic acid (NDGA). Some chemicals found in trace amounts in food, as well as some dietary supplements, have been shown to inhibit 5-LOX; these include baicalein, caffeic acid, curcumin, hyperforin and St John's wort. 1. Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes ...2. Prostaglandin G/H synthase 1 ... General function: Involved in peroxidase activity ace ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antineoplastic Drugs
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called ''medical oncology''. The term ''chemotherapy'' has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). The development of therapies with specific molecular or genetic targets, w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
