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Mark L. Nelson
Mark L. Nelson (born 1960) is an American chemist specializing in the field of antibiotics and tetracyclines. His synthesis techniques have resulted in over 40 patents and he conceived and synthesized with Mohamed Ismail along with Laura Honeyman and Kwasi Ohemeng, the tetracycline antibiotic Omadacycline (Nuzyra), the first of the Aminomethylcycline subclass of tetracyclines to reach medical use. Research His current research is directed at modulating alpha-proteobacteria and related mitochondria and their signaling processes, and new compounds are in pre-clinical studies affecting activated immune cells showing promise against the secondary effects of stroke, hypoxia and neurodegeneration, in studies funded by the Department of Defense, with Marc Halterman, PhD, MD. Other tetracycline compounds that are non-antibiotic compounds effective against mitochondrial processes are being studied with Johan Auwerx at EPFL, Lausanne, Switzerland, and Andrew Dillin at the University ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tufts University
Tufts University is a private research university in Medford and Somerville, Massachusetts, United States, with additional facilities in Boston and Grafton, as well as Talloires, France. Tufts also has several Doctor of Physical Therapy programs located in Boston, Phoenix and Seattle. It was founded in 1852 as Tufts College by Christian universalists who sought to provide a nonsectarian institution of higher learning. Tufts remained a small liberal arts college until the 1970s, when it transformed into a large research university offering doctorates in several disciplines. The corporate name of the university is "Trustees of Tufts College". Tufts offers over 90 undergraduate and 160 graduate programs across ten schools in the greater Boston area and Talloires, France.Bylaws ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Berkeley
The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California), is a Public university, public Land-grant university, land-grant research university in Berkeley, California, United States. Founded in 1868 and named after the Anglo-Irish philosopher George Berkeley, it is the state's first land-grant university and is the founding campus of the University of California system. Berkeley has an enrollment of more than 45,000 students. The university is organized around fifteen schools of study on the same campus, including the UC Berkeley College of Chemistry, College of Chemistry, the UC Berkeley College of Engineering, College of Engineering, UC Berkeley College of Letters and Science, College of Letters and Science, and the Haas School of Business. It is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity". Lawrence Berkeley National Laboratory was originally founded as par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Community-acquired Pneumonia
Community-acquired pneumonia (CAP) refers to pneumonia contracted by a person outside of the healthcare system. In contrast, hospital-acquired pneumonia (HAP) is seen in patients who are in a hospital or who have recently been hospitalized in the last 48 hours. Those who live in long-term care facilities or who had pneumonia after 48 hours of hospitalization for another cause are also classified as having CAP (they were previously designated as having HCAP (healthcare associated pneumonia)). CAP is common, affecting people of all ages, and its symptoms occur as a result of oxygen-absorbing areas of the lung ( alveoli) becoming colonized by a pathogenic microorganism (such as bacteria, viruses or fungi). The resulting inflammation and tissue damage causes fluid to fill the alveoli, inhibiting lung function and causing the symptoms of the disease. Common symptoms of CAP include dyspnea, fever, chest pains and cough. 10% of those with CAP are hospitalized. The 30 day mortality for tho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Skin And Skin Structure Infection
Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation. Other animal coverings, such as the arthropod exoskeleton, have different developmental origin, structure and chemical composition. The adjective cutaneous means "of the skin" (from Latin ''cutis'' 'skin'). In mammals, the skin is an organ of the integumentary system made up of multiple layers of ectodermal tissue and guards the underlying muscles, bones, ligaments, and internal organs. Skin of a different nature exists in amphibians, reptiles, and birds. Skin (including cutaneous and subcutaneous tissues) plays crucial roles in formation, structure, and function of extraskeletal apparatus such as horns of bovids (e.g., cattle) and rhinos, cervids' antlers, giraffids' ossicones, armadillos' osteoderm, and os penis/os clitoris. All mammals have some hair on their skin, even marine mammals like whales, dolph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteria
Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of Prokaryote, prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit the air, soil, water, Hot spring, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria play a vital role in many stages of the nutrient cycle by recycling nutrients and the nitrogen fixation, fixation of nitrogen from the Earth's atmosphere, atmosphere. The nutrient cycle includes the decomposition of cadaver, dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tufts University School Of Medicine
The Tufts University School of Medicine is the medical school of Tufts University, a Private university, private research university in Massachusetts. It was established in 1893 and is located on the university's health sciences campus in downtown Boston. It has clinical affiliations with numerous doctors and researchers in the United States and around the world, as well as with its affiliated hospitals in both Massachusetts (including Tufts Medical Center, St. Elizabeth's Medical Center (Boston), St. Elizabeth's Medical Center, Lahey Hospital & Medical Center, Lahey Hospital and Medical Center and Baystate Medical Center), and Maine (Maine Medical Center). History The School of Medicine was established by vote of the Trustees of Tufts College on April 22, 1893. It was formed by the secession of seven faculty from the College of Physicians and Surgeons in Boston, a school which was formed in 1880. These "original seven" faculty members successfully lobbied to establish a medic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cheminformatics
Cheminformatics (also known as chemoinformatics) refers to the use of physical chemistry theory with computer and information science techniques—so called "'' in silico''" techniques—in application to a range of descriptive and prescriptive problems in the field of chemistry, including in its applications to biology and related molecular fields. Such '' in silico'' techniques are used, for example, by pharmaceutical companies and in academic settings to aid and inform the process of drug discovery, for instance in the design of well-defined combinatorial libraries of synthetic compounds, or to assist in structure-based drug design. The methods can also be used in chemical and allied industries, and such fields as environmental science and pharmacology, where chemical processes are involved or studied. History Cheminformatics has been an active field in various guises since the 1970s and earlier, with activity in academic departments and commercial pharmaceutical rese ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetracycline Antibiotics
Tetracyclines are a group of broad-spectrum antibiotic compounds that have a common basic structure and are either isolated directly from several species of ''Streptomyces'' bacteria or produced semi-synthetically from those isolated compounds. Tetracycline molecules comprise a linear fused tetracyclic nucleus (rings designated A, B, C and D) to which a variety of functional groups are attached. Tetracyclines are named after their four ("tetra-") hydrocarbon rings ("-cycl-") derivation ("-ine"). They are defined as a subclass of polyketides, having an octahydrotetracene-2-carboxamide skeleton and are known as derivative (chemistry), derivatives of polycyclic naphthacene carboxamide. While all tetracyclines have a common structure, they differ from each other by the presence of chloro, methyl, and hydroxyl groups. These chemical modification, modifications do not change their broad antibacterial activity, but do affect pharmacological properties such as half-life and binding to pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Discovery Channel
Discovery Channel, known as The Discovery Channel from 1985 to 1995, and often referred to as simply Discovery, is an American cable channel that is best known for its ongoing reality television shows and promotion of pseudoscience. It initially provided documentary television programming focused primarily on popular science, technology, and history, but by the 2010s had become increasingly dominated by programs that were reality television shows, promoted conspiracy theories, or advocated junk science. It is owned by Warner Bros. Discovery, a publicly traded company run by CEO David Zaslav. , Discovery Channel was the third most widely distributed subscription channel in the United States, behind now-sibling channel TBS and the Weather Channel; it is available in 409 million households worldwide, through its U.S. flagship channel and its various owned or licensed television channels internationally. , Discovery Channel is available to approximately 71,000,000 pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrogen Fluoride
Hydrogen fluoride (fluorane) is an Inorganic chemistry, inorganic compound with chemical formula . It is a very poisonous, colorless gas or liquid that dissolves in water to yield hydrofluoric acid. It is the principal industrial source of fluorine, often in the form of hydrofluoric acid, and is an important feedstock in the preparation of many important compounds including pharmaceuticals and polymers such as polytetrafluoroethylene (PTFE). HF is also widely used in the petrochemical industry as a component of superacids. Due to strong and extensive hydrogen bonding, it boils near room temperature, a much higher temperature than other hydrogen halides. Hydrogen fluoride is an extremely dangerous gas, forming corrosive and penetrating hydrofluoric acid upon contact with moisture. The gas can also cause blindness by rapid destruction of the corneas. History In 1771 Carl Wilhelm Scheele prepared the aqueous solution, hydrofluoric acid in large quantities, although hydrofluoric acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Archaeobiology
Archaeobiology, the study of the biology of ancient times through archaeological materials, is a subspecialty of archaeology. It can be seen as a blanket term for paleobotany, animal osteology, zooarchaeology, microbiology, and many other sub-disciplines. Specifically, plant and animal remains are also called ecofacts. Sometimes these ecofacts can be left by humans and sometimes they can be naturally occurring. Archaeobiology tends to focus on more recent finds, so the difference between archaeobiology and palaeontology is mainly one of date: archaeobiologists typically work with more recent, non-fossilised material found at archaeological sites. Only very rarely are archaeobiological excavations performed at sites with no sign of human presence. Flora and Fauna in Archaeology The prime interest of paleobotany is to reconstruct the vegetation that people in the past would have encountered in a particular place and time. Plant studies have always been overshadowed by faunal studies b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Candidatus
In prokaryote nomenclature, ''Candidatus'' (abbreviated ''Ca.''; Latin for "candidate of Roman office") is used to name prokaryotic taxa that are well characterized but yet- uncultured. Contemporary sequencing approaches, such as 16S ribosomal RNA sequencing or metagenomics, provide much information about the analyzed organisms and thus allow identification and characterization of individual species. However, the majority of prokaryotic species remain uncultivable and hence inaccessible for further characterization in ''in vitro'' study. The recent discoveries of a multitude of candidate taxa has led to candidate phyla radiation expanding the tree of life through the new insights in bacterial diversity. Nomenclature History The initial International Code of Nomenclature of Prokaryotes (ICNP) as well as early revisions did not account for the possibility of identifying prokaryotes which were not yet cultivable. This was in apparent conflict with the ICNP's stated scope, which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
