Mark L. Nelson (born 1960) is an American

chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a graduated scientist trained in the study of chemistry, or an officially enrolled student in the field. Chemists study the composition of ...

specializing in the field of

antibiotics An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...

and

tetracyclines Tetracyclines are a group of broad-spectrum antibiotic compounds that have a common basic structure and are either isolated directly from several species of ''Streptomyces'' bacteria or produced semi-synthetically from those isolated compounds. ...

. His synthesis techniques have resulted in over 40

patent A patent is a type of intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an sufficiency of disclosure, enabling discl ...

s and he conceived and synthesized with Mohamed Ismail along with Laura Honeyman and Kwasi Ohemeng, the tetracycline antibiotic Omadacycline (Nuzyra), the first of the Aminomethylcycline subclass of

to reach medical use.

Research

His current research is directed at modulating alpha-proteobacteria and related mitochondria and their signaling processes, and new compounds are in pre-clinical studies affecting activated immune cells showing promise against the secondary effects of

stroke Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemor ...

, hypoxia and

neurodegeneration A neurodegenerative disease is caused by the progressive loss of neurons, in the process known as neurodegeneration. Neuronal damage may also ultimately result in their cell death, death. Neurodegenerative diseases include amyotrophic lateral sc ...

, in studies funded by the

Department of Defense The United States Department of Defense (DoD, USDOD, or DOD) is an executive department of the U.S. federal government charged with coordinating and supervising the six U.S. armed services: the Army, Navy, Marines, Air Force, Space Force, ...

, with Marc Halterman, PhD, MD. Other

tetracycline Tetracycline, sold under various brand names, is an antibiotic in the tetracyclines family of medications, used to treat a number of infections, including acne, cholera, brucellosis, plague, malaria, and syphilis. It is available in oral an ...

compounds that are non-antibiotic compounds effective against

mitochondrial A mitochondrion () is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used ...

processes are being studied with Johan Auwerx at EPFL, Lausanne, Switzerland, and Andrew Dillin at the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California), is a Public university, public Land-grant university, land-grant research university in Berkeley, California, United States. Founded in 1868 and named after t ...

. In agriculture and with the

USDA The United States Department of Agriculture (USDA) is an United States federal executive departments, executive department of the Federal government of the United States, United States federal government that aims to meet the needs of commerc ...

and the Citrus Research Development Foundation his research has led to series of compounds active against Huanglongbing, known as Citrus Greening, an infectious disease in citrus caused by this invasive species of alpha-proteobacteria that has devastated the Florida citrus industry, and compounds from his labs completed field studies showing potent activity in sparing citrus trees from this

pathogen In biology, a pathogen (, "suffering", "passion" and , "producer of"), in the oldest and broadest sense, is any organism or agent that can produce disease. A pathogen may also be referred to as an infectious agent, or simply a Germ theory of d ...

also known as ''Liberibacter asiaticus'' (

Candidatus In prokaryote nomenclature, ''Candidatus'' (abbreviated ''Ca.''; Latin for "candidate of Roman office") is used to name prokaryotic taxa that are well characterized but yet- uncultured. Contemporary sequencing approaches, such as 16S ribosomal R ...

). In the field of archaeobiology Nelson is first author of ''Mass spectroscopic characterization of tetracycline in the skeletal remains of an ancient population from Sudanese Nubia 350–550 CE'', published in 2010, which reported that ancient civilizations were producing antibiotics and used them to treat diseases. His work used anhydrous

hydrogen fluoride Hydrogen fluoride (fluorane) is an Inorganic chemistry, inorganic compound with chemical formula . It is a very poisonous, colorless gas or liquid that dissolves in water to yield hydrofluoric acid. It is the principal industrial source of fluori ...

to dissolve mummy bones found in Nubia followed by mass spectroscopic characterization. This research was chronicled in the documentary "How Beer Saved the World" produced by the

Discovery Channel Discovery Channel, known as The Discovery Channel from 1985 to 1995, and often referred to as simply Discovery, is an American cable channel that is best known for its ongoing reality television shows and promotion of pseudoscience. It init ...

. He also is known for his scientific research into the non-antibiotic uses of the

and for his work on the history of the compoundsand in

chemoinformatics Cheminformatics (also known as chemoinformatics) refers to the use of physical chemistry theory with computer and information science techniques—so called "''in silico''" techniques—in application to a range of descriptive and prescriptive pr ...

, drug design innovation and chemical discovery. Omadacycline was developed at

Tufts University School of Medicine The Tufts University School of Medicine is the medical school of Tufts University, a Private university, private research university in Massachusetts. It was established in 1893 and is located on the university's health sciences campus in down ...

by a research team led by Nelson. Working alongside Mohamed Ismail at Tufts, Nelson played a role in applying chemistry methods to

scaffolds.https://journals.indexcopernicus.com/api/file/viewByFileId/805182 Omadacycline: Recently Approved Antimicrobial Agent His team synthesized over 3,000 new derivatives, ultimately leading to the discovery of novel third-generation tetracycline compounds, including omadacycline and sarecycline. Nuzyra is useful against resistant

bacteria Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of Prokaryote, prokaryotic microorganisms. Typically a few micr ...

and used for severe cases of skin infections, ABSSSIs,

Community Acquired Pneumonia Community-acquired pneumonia (CAP) refers to pneumonia contracted by a person outside of the healthcare system. In contrast, hospital-acquired pneumonia (HAP) is seen in patients who are in a hospital or who have recently been hospitalized in the ...

(CABP) and nontuberculosis mycobacteria. Nuzyra also has demonstrated activity against

Anthrax Anthrax is an infection caused by the bacterium '' Bacillus anthracis'' or ''Bacillus cereus'' biovar ''anthracis''. Infection typically occurs by contact with the skin, inhalation, or intestinal absorption. Symptom onset occurs between one ...

, and was purchased by the US government under a BARDA contract for Project Bio-shield to treat

anthrax Anthrax is an infection caused by the bacterium '' Bacillus anthracis'' or ''Bacillus cereus'' biovar ''anthracis''. Infection typically occurs by contact with the skin, inhalation, or intestinal absorption. Symptom onset occurs between one ...

exposure (''

Bacillus anthracis ''Bacillus anthracis'' is a gram-positive and rod-shaped bacterium that causes anthrax, a deadly disease to livestock and, occasionally, to humans. It is the only permanent (obligate) pathogen within the genus ''Bacillus''. Its infection is a ty ...

''), and is now in the

Strategic National Stockpile The Strategic National Stockpile (SNS), originally called the National Pharmaceutical Stockpile (NPS), is the United States' national repository of antibiotics, vaccines, chemical antidotes, antitoxins, and other critical medical supplies. Its ...

in the US in case of a

bioterrorism Bioterrorism is terrorism involving the intentional release or dissemination of biological agents. These agents include bacteria, viruses, insects, fungi, and/or their toxins, and may be in a naturally occurring or a human-modified form, in mu ...

attack. Nuzyra was also approved for use against the Plague, caused by ''

Yersinia pestis ''Yersinia pestis'' (''Y. pestis''; formerly ''Pasteurella pestis'') is a Gram-negative bacteria, gram-negative, non-motile bacteria, non-motile, coccobacillus Bacteria, bacterium without Endospore, spores. It is related to pathogens ''Yer ...

'' infections.

Awards

Nelson received a Fulbright Lectureship Fellow Award, Cairo, Egypt, for his research into antibiotic resistance mechanisms working with the National Research Center, the Distinguished Alumni Award in Science at

Gannon University Gannon University is a private Catholic university with campuses in Erie, Pennsylvania, and Ruskin, Florida, United States. Established in 1925, Gannon University enrolls approximately 4,600 undergraduate and graduate students annually. Its i ...

(2003) and more recently he received the 2019 American Chemistry Society Heroes of Chemistry award for his synthetic and biological work leading to the marketed drugs Nuzyra and Seysara, which were approved by the

FDA The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...

in October 2018 for use as antibiotics in health and medicine.

References

External links

Patents by Mark L. Nelson
{{DEFAULTSORT:Nelson, Mark L. Living people American science writers 1960 births