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Logan Plot
A Logan plot (or Logan graphical analysis) is a graphical analysis technique based on the compartment model that uses linear regression to analyze pharmacokinetics of tracers involving reversible uptake. It is mainly used for the evaluation of nuclear medicine imaging data after the injection of a labeled ligand that binds reversibly to specific receptor or enzyme. In conventional compartmental analysis, an iterative method is used to fit the individual model parameters in the solution of a compartmental model of specific configuration to the measurements with a measured plasma time-activity curve that serves as an forcing (input) function, and the binding of the tracer can then be described. Graphical analysis is a simplified method that transforms the model equations into a linear equation evaluated at multiple time points and provides fewer parameters (i.e., slope and intercept). Although the slope and the intercept can be interpreted in terms of a combination of model paramete ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Cerebral Blood Flow And Metabolism
The ''Journal of Cerebral Blood Flow & Metabolism'' is a monthly peer-reviewed medical journal the official journal of the International Society for Cerebral Blood Flow & Metabolism and publishes peer-reviewed Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work (peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer review ... research and review papers. covering research on experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The editor-in-chief is Jun Chen ( University of Pittsburgh). According to the '' Journal Citation Reports'', the journal has a 2020 impact factor of 6.200. References External links * International Society for Cerebral Blood Flow & Metabolism Neuroscience journals Publications established in 1981 Nature Research academic journals English-language journals Monthly journals Del ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brookhaven National Laboratory
Brookhaven National Laboratory (BNL) is a United States Department of Energy national laboratory located in Upton, Long Island, and was formally established in 1947 at the site of Camp Upton, a former U.S. Army base and Japanese internment camp. Its name stems from its location within the Town of Brookhaven, approximately 60 miles east of New York City. It is managed by Stony Brook University and Battelle Memorial Institute. Research at BNL includes nuclear and high energy physics, energy science and technology, environmental and bioscience, nanoscience, and national security. The 5,300 acre campus contains several large research facilities, including the Relativistic Heavy Ion Collider and National Synchrotron Light Source II. Seven Nobel Prizes have been awarded for work conducted at Brookhaven Lab. Overview BNL is staffed by approximately 2,750 scientists, engineers, technicians, and support personnel, and hosts 4,000 guest investigators every year. The laboratory has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mathematical Modeling
A mathematical model is a description of a system using mathematical concepts and language. The process of developing a mathematical model is termed mathematical modeling. Mathematical models are used in the natural sciences (such as physics, biology, earth science, chemistry) and engineering disciplines (such as computer science, electrical engineering), as well as in non-physical systems such as the social sciences (such as economics, psychology, sociology, political science). The use of mathematical models to solve problems in business or military operations is a large part of the field of operations research. Mathematical models are also used in music, linguistics, and philosophy (for example, intensively in analytic philosophy). A model may help to explain a system and to study the effects of different components, and to make predictions about behavior. Elements of a mathematical model Mathematical models can take many forms, including dynamical systems, statistica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Distribution Volume
In pharmacology, the volume of distribution (VD, also known as apparent volume of distribution, literally, ''volume of dilution'') is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma. In other words, it is the ratio of ''amount of drug in a body (dose)'' to ''concentration of the drug that is measured in blood, plasma, and un-bound in interstitial fluid''. The VD of a drug represents the degree to which a drug is distributed in body tissue rather than the plasma. VD is directly proportional with the amount of drug distributed into tissue; a higher VD indicates a greater amount of tissue distribution. A VD greater than the total volume of body water (approximately 42 liters in humans) is possible, and would indicate that the drug is highly distributed into tissue. In other words, the volume of distribution is smaller in the drug staying in the plasma than that of a dr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Binding Potential
In pharmacokinetics and receptor-ligand kinetics the binding potential (BP) is a combined measure of the density of "available" neuroreceptors and the affinity of a drug to that neuroreceptor. Description Consider a ligand receptor binding system. Ligand with a concentration ''L'' associates with a receptor of concentration or availability ''R'' to form a ligand-receptor complex with concentration ''RL''. The binding potential is then the ratio ligand-receptor complex to free ligand at equilibrium and in the limit of L tending to 0, and is given symbol BP: BP=\frac\bigg, _ This quantity, originally defined by Mintun, describes the capacity of a receptor to bind ligand. It is a limit (L << Ki) of the general receptor association equation: and is thus also equivalent to: These equations apply equally when measuring the total receptor density or the residual receptor density available after binding to second ligand - availability. < ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Positron Emission Tomography
Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example: * Fluorodeoxyglucose ( 18F">sup>18FDG or FDG) is commonly used to detect cancer; * 18Fodium fluoride">sup>18Fodium fluoride (Na18F) is widely used for detecting bone formation; * Oxygen-15 (15O) is sometimes used to measure blood flow. PET is a common imaging technique, a medical scintillography technique used in nuclear medicine. A radiopharmaceutical – a radioisotope attached to a drug – is injected into the body as a radioactive tracer, tracer. When the radiopharmaceutical undergoes beta plus decay, a positron is emitted, and when the positron interacts with an or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partition Coefficient
In the physical sciences, a partition coefficient (''P'') or distribution coefficient (''D'') is the ratio of concentrations of a compound in a mixture of two immiscible solvents at equilibrium. This ratio is therefore a comparison of the solubilities of the solute in these two liquids. The partition coefficient generally refers to the concentration ratio of un-ionized species of compound, whereas the distribution coefficient refers to the concentration ratio of all species of the compound (ionized plus un-ionized). In the chemical and pharmaceutical sciences, both phases usually are solvents. Most commonly, one of the solvents is water, while the second is hydrophobic, such as 1-octanol. Hence the partition coefficient measures how hydrophilic ("water-loving") or hydrophobic ("water-fearing") a chemical substance is. Partition coefficients are useful in estimating the distribution of drugs within the body. Hydrophobic drugs with high octanol-water partition coefficients are ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dissociation Constant
In chemistry, biochemistry, and pharmacology, a dissociation constant (K_D) is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into its component ions. The dissociation constant is the inverse of the association constant. In the special case of salts, the dissociation constant can also be called an ionization constant. For a general reaction: : A_\mathit B_\mathit \mathit A + \mathit B in which a complex \ce_x \ce_y breaks down into ''x'' A subunits and ''y'' B subunits, the dissociation constant is defined as : K_D = \frac where and ''x'' B''y''are the equilibrium concentrations of A, B, and the complex A''x'' B''y'', respectively. One reason for the popularity of the dissociation constant in biochemistry and pharmacology is that in the frequently en ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Distribution Volume
In pharmacology, the volume of distribution (VD, also known as apparent volume of distribution, literally, ''volume of dilution'') is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma. In other words, it is the ratio of ''amount of drug in a body (dose)'' to ''concentration of the drug that is measured in blood, plasma, and un-bound in interstitial fluid''. The VD of a drug represents the degree to which a drug is distributed in body tissue rather than the plasma. VD is directly proportional with the amount of drug distributed into tissue; a higher VD indicates a greater amount of tissue distribution. A VD greater than the total volume of body water (approximately 42 liters in humans) is possible, and would indicate that the drug is highly distributed into tissue. In other words, the volume of distribution is smaller in the drug staying in the plasma than that of a dr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Binding (molecular)
Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other. It is formed when atoms or molecules bind together by sharing of electrons. It often, but not always, involves some chemical bonding. In some cases, the associations can be quite strong—for example, the protein streptavidin and the vitamin biotin have a dissociation constant (reflecting the ratio between bound and free biotin) on the order of 10−14—and so the reactions are effectively irreversible. The result of molecular binding is sometimes the formation of a molecular complex in which the attractive forces holding the components together are generally non-covalent, and thus are normally energetically weaker than covalent bonds. Molecular binding occurs in biological complexes (e.g., between pairs or sets of proteins, or between a protein and a small molecule ligand it binds) and also in abiologic chemica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Division (mathematics)
Division is one of the four basic operations of arithmetic, the ways that numbers are combined to make new numbers. The other operations are addition, subtraction, and multiplication. At an elementary level the division of two natural numbers is, among other possible interpretations, the process of calculating the number of times one number is contained within another. This number of times need not be an integer. For example, if 20 apples are divided evenly between 4 people, everyone receives 5 apples (see picture). The division with remainder or Euclidean division of two natural numbers provides an integer ''quotient'', which is the number of times the second number is completely contained in the first number, and a ''remainder'', which is the part of the first number that remains, when in the course of computing the quotient, no further full chunk of the size of the second number can be allocated. For example, if 21 apples are divided between 4 people, everyone receives ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Region Of Interest
A region of interest (often abbreviated ROI) is a sample within a data set identified for a particular purpose. The concept of a ROI is commonly used in many application areas. For example, in medical imaging, the boundaries of a tumor may be defined on an image or in a volume, for the purpose of measuring its size. The endocardial border may be defined on an image, perhaps during different phases of the cardiac cycle, for example, end-systole and end-diastole, for the purpose of assessing cardiac function. In geographical information systems (GIS), a ROI can be taken literally as a polygonal selection from a 2D map. In computer vision and optical character recognition, the ROI defines the borders of an object under consideration. In many applications, symbolic (textual) labels are added to a ROI, to describe its content in a compact manner. Within a ROI may lie individual ''points of interest'' (POIs). Examples of regions of interest * 1D dataset: a time or frequency interval on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
