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Lex Van Der Eb
Alex Jan "Lex" van der Eb (born 16 January 1934) is a Dutch molecular biologist and virologist. He was a professor of fundamental tumor virology and later molecular carcinogenesis at Leiden University from 1979 to 2000. He has performed research in adenoviruses and was fundamental in the creation of the technique of calcium phosphate transfection and the founding of the HEK 293 and PER.C6 cell lines. Life Van der Eb was born on 16 January 1934 in Bandung, Dutch East Indies. He studied biology at Leiden University and afterwards attended Delft University of Technology for a further year to specialize in microbiology. Van der Eb had to fulfill his military service upon graduation and asked the head of military health services to be employed in one of the military laboratories. In 1962 he was sent to work as a biologist on poxviruses in the virology department of Leiden University. At Leiden he met professor J.A. Cohen of the Medical-Biological Laboratory of the Netherlands Organis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bandung
Bandung is the capital city of the West Java province of Indonesia. Located on the island of Java, the city is the List of Indonesian cities by population, fourth-most populous city and fourth largest city in Indonesia after Jakarta, Surabaya, and Medan. Greater Bandung (Bandung Basin Metropolitan Area / BBMA) is the country's second-largest and second most populous List of metropolitan areas in Indonesia, metropolitan area, with over 11 million inhabitants. Situated above sea level (the highest point in the North area is at an altitude of , and the lowest in the South at above sea level), approximately southeast of Jakarta, Bandung has cooler year-round temperatures than most other List of cities in Indonesia, Indonesian cities. The city lies in a river basin surrounded by volcanic mountains that provide a natural defense system, which was the primary reason for the Dutch East Indies government's plan to move the capital from Batavia (modern-day Jakarta) to Bandung. The D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Phenotypic trait, Trait inheritance and Molecular genetics, molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the Cell (bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johnson & Johnson
Johnson & Johnson (J&J) is an American multinational pharmaceutical, biotechnology, and medical technologies corporation headquartered in New Brunswick, New Jersey, and publicly traded on the New York Stock Exchange. Its common stock is a component of the Dow Jones Industrial Average, and the company is ranked No. 42 on the 2024 ''Fortune'' 500 list of the largest United States corporations. In 2024, the company was ranked 45th in the ''Forbes'' Global 2000. Johnson & Johnson has a global workforce of approximately 138,000 employees who are led by the company's current chairman and chief executive officer, Joaquin Duato. Johnson & Johnson was founded in 1886 by three brothers, Robert Wood Johnson, James Wood Johnson, and Edward Mead Johnson, selling ready-to-use sterile surgical dressings. In 2023, the company split-off its consumer healthcare business segment into a new publicly traded company, Kenvue. The company is exclusively focused on developing and producing ph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pandemic
A pandemic ( ) is an epidemic of an infectious disease that has a sudden increase in cases and spreads across a large region, for instance multiple continents or worldwide, affecting a substantial number of individuals. Widespread endemic (epidemiology), endemic diseases with a stable number of infected individuals such as recurrences of seasonal influenza are generally excluded as they occur simultaneously in large regions of the globe rather than being spread worldwide. Throughout human history, there have been a number of pandemics of diseases such as smallpox. The Black Death, caused by the Plague (disease), Plague, caused the deaths of up to half of the population of Europe in the 14th century. The term ''pandemic'' had not been used then, but was used for later epidemics, including the 1918 Influenza A virus subtype H1N1, H1N1 influenza A pandemic—more commonly known as the Spanish flu—which is the Deadliest pandemics in history, deadliest pandemic in history. The mos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COVID-19 Pandemic In The Netherlands
The COVID-19 pandemic in the Netherlands has resulted in confirmed cases of COVID-19 and deaths. The virus reached the Netherlands on 27 February 2020, when its first COVID-19 case was confirmed in Tilburg. It involved a 56-year-old Dutchman who had arrived in the Netherlands from Italy. The virus was confirmed to have reached Europe on 24 January 2020, when the first COVID-19 case was identified in Bordeaux - France. As of 31 January 2021, there are 978,475 confirmed cases of infections and 13,998 confirmed deaths. The first death occurred on 6 March, when an 86-year-old patient died in Rotterdam. On the advice of the Outbreak Management Team (OMT), under supervision of Jaap van Dissel, measures were taken by the Third Rutte cabinet for the public health to prevent the spread of this viral disease, including the "intelligent lockdown". The government strategy on pandemic control has been criticised for the refusal to acknowledge the role of asymptomatic spread and the role o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Netherlands Academy Of Arts And Sciences
The Royal Netherlands Academy of Arts and Sciences (, KNAW) is an organization dedicated to the advancement of science and literature in the Netherlands. The academy is housed in the Trippenhuis in Amsterdam. In addition to various advisory and administrative functions it operates a number of research institutes and awards many prizes, including the Lorentz Medal in theoretical physics, the Dr Hendrik Muller Prize for Behavioural and Social Science and the Heineken Prizes. Main functions The academy advises the Dutch government on scientific matters. While its advice often pertains to genuine scientific concerns, it also counsels the government on such topics as policy on careers for researchers or the Netherlands' contribution to major international projects. The academy offers solicited and unsolicited advice to parliament, ministries, universities and research institutes, funding agencies and international organizations. * Advising the government on matters related to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biosecurity
Biosecurity refers to measures aimed at preventing the introduction or spread of harmful organisms (e.g. viruses, bacteria, plants, animals etc.) intentionally or unintentionally outside their native range or within new environments. In agriculture, these measures are aimed at protecting food crops and livestock from pest (organism), pests, invasive species, and other organisms not conducive to the welfare of the human population. The term includes Biological pest control, biological threats to people, including those from pandemic diseases and bioterrorism. The definition has sometimes been broadened to embrace other concepts, and it is used for different purposes in different contexts. The COVID-19 pandemic is a recent example of a threat for which biosecurity measures have been needed in all countries of the world. Background and terminology The term "biosecurity" has been defined differently by various disciplines. The term was first used by the agricultural and environmenta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zika Fever
Zika fever, also known as Zika virus disease or simply Zika, is an infectious disease caused by the Zika virus. Most cases have no symptoms, but when present they are usually mild and can resemble dengue fever. Symptoms may include fever, conjunctivitis, red eyes, arthralgia, joint pain, headache, and a maculopapular rash. Symptoms generally last less than seven days. It has not caused any reported deaths during the initial infection. Vertically transmitted disease, Mother-to-child transmission during pregnancy can cause microcephaly and other brain malformations in some babies. Infections in adults have been linked to Guillain–Barré syndrome (GBS). Zika fever is mainly spread via the bite of mosquitoes of the ''Aedes'' type. It can also be sexually transmitted infection, sexually transmitted and potentially spread by blood transfusions. Infections in pregnant women can spread to the baby. Diagnosis is by testing the blood, urine, or saliva for the presence of the virus's RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ebola
Ebola, also known as Ebola virus disease (EVD) and Ebola hemorrhagic fever (EHF), is a viral hemorrhagic fever in humans and other primates, caused by ebolaviruses. Symptoms typically start anywhere between two days and three weeks after infection. The first symptoms are usually fever, sore throat, muscle pain, and headaches. These are usually followed by vomiting, diarrhoea, rash and decreased liver and kidney function, at which point some people begin to bleed both internally and externally. It kills between 25% and 90% of those infected – about 50% on average. Death is often due to shock from fluid loss, and typically occurs between 6 and 16 days after the first symptoms appear. Early treatment of symptoms increases the survival rate considerably compared to late start.Ebola in Uganda: An Ebola vaccine was approved by the US FDA in December 2019. The virus spreads through direct contact with body fluids, such as blood from infected humans or other animals, o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crucell
Janssen Vaccines, formerly Crucell, is a biotechnology company specializing in vaccines and biopharmaceutical technologies. It was formed when Johnson & Johnson acquired the Dutch biotech company Crucell. Janssen Vaccines is part of Johnson & Johnson Innovative Medicine business segment. __TOC__ History In 1993 Introgene, Crucell's predecessor, was established as a spin-off of Leiden University. The company formed a partnership with Genzyme to collaborate on its vector technology and viral-based products. In 1999 the company founded Galapagos Genomics as a joint venture together with Tibotec. In 2000 IntroGene acquired U-Bisys to form Crucell. In 2006, Crucell and Swiss Berna Biotech; Swedish SBL Vaccines and US-based Berna Products joined forces to become the sixth largest vaccine company worldwide, with their own clinical programs. On 7 January 2009 Crucell released a press release saying Crucell and Wyeth were in discussion on a merger of the two companies. On 26 January ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Therapy
Gene therapy is Health technology, medical technology that aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells. The first attempt at modifying human DNA was performed in 1980, by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. Between 1989 and December 2018, over 2,900 clinical trials were conducted, with more than half of them in Phases of clinical research, phase I. In 2003, Gendicine became the first gene therapy to receive regulatory approval. Since that time, further gene therapy drugs were approved, such as alipogene tiparvovec (2012), Strimvelis (2016), tisagenlecleucel (2017), voretigene neparvovec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chicken Anemia Virus
Chicken anemia virus (CAV), scientific name ''Gyrovirus chickenanemia'', is a member of the ''Anelloviridae'' family which is found worldwide. The virus only affects chickens. CAV is a non-enveloped icosahedral single-stranded DNA virus, which causes bone marrow atrophy, anemia, and severe immunosuppression. Clinical signs of CAV infection are predominantly found in young chicks due to vertical transmission from the breeder hens whose maternal antibodies have not yet formed following exposure. Clinical disease is rare today because of the widespread practice of vaccinating breeders, but the subclinical form of the disease—which normally affects birds more than two weeks of age following horizontal transmission of the virus via the fecal–oral route—is ubiquitous. The virus is very resistant in the environment, making elimination very difficult. The disease and virus have many names including chicken anemia, blue wing disease, anemia dermatitis syndrome, chicken/avian infectio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
