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Lewis C. Cantley
Lewis C. Cantley (born February 20, 1949) is an American cell biologist and biochemist who has made significant advances to the understanding of cancer metabolism. Among his most notable contributions are the discovery and study of the enzyme PI-3-kinase, now known to be important to understanding cancer and diabetes mellitus. He was Meyer Director and Professor of Cancer Biology at the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine in New York City. He is a professor in the Departments of Systems Biology and Medicine at Harvard Medical School, and the Director of Cancer Research at the Beth Israel Deaconess Medical Center, in Boston, Massachusetts. In 2016, he was elected Chairman of the Board for the Hope Funds for Cancer Research. Biography Cantley grew up in West Virginia, remaining there at Wesleyan College where he graduated summa cum laude in chemistry in 1971. Cantley obtained his PhD at Cornell University in Ithaca, New York, where he worked with Gordon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
West Virginia
West Virginia is a mountainous U.S. state, state in the Southern United States, Southern and Mid-Atlantic (United States), Mid-Atlantic regions of the United States.The United States Census Bureau, Census Bureau and the Association of American Geographers classify West Virginia as part of the Southern United States while the Bureau of Labor Statistics classifies the state as a part of the Mid-Atlantic (United States), Mid-Atlantic regionMid-Atlantic Home : Mid-Atlantic Information Office: U.S. Bureau of Labor Statistics" www.bls.gov. Archived. It is bordered by Pennsylvania and Maryland to the northeast, Virginia to the southeast, Kentucky to the southwest, and Ohio to the northwest. West Virginia is the List of U.S. states and territories by area, 10th-smallest state by area and ranks as the List of U.S. states and territories by population, 12th-least populous state, with a population of 1,769,979 residents. The capital and List of municipalities in West Virginia, most populou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Weill Cornell Medicine
Weill Cornell Medicine (; officially Joan and Sanford I. Weill Medical College of Cornell University), originally Cornell University Medical College, is the medical school of Cornell University, located on the Upper East Side of Manhattan in New York City. The school and its associated research organization is affiliated with several hospitals and medical centers, including NewYork-Presbyterian Hospital, Weill Cornell Medical Center, Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, and Rockefeller University, all of which are located on or near York Avenue and Sutton Place. Since 2004, Weill Cornell has also been affiliated with The Methodist Hospital, Houston Methodist Hospital. In 1991, Memorial Sloan Kettering Cancer Center and Rockefeller University joined Weill Cornell to establish the Tri-Institutional MD–PhD Program. In 2001, the school opened the Weill Cornell Medical College in Qatar, a medical school in Qatar. History 19th century The Cornell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MTOR
The mammalian target of rapamycin (mTOR), also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the ''MTOR'' gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenanc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TSC2
Tuberous sclerosis complex 2 (TSC2), also known as tuberin, is a protein that in humans is encoded by the ''TSC2'' gene. Function Mutations in this gene lead to tuberous sclerosis. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. Hamartin coded by the gene TSC1 functions as a facilitator of Hsp90 in chaperoning of tuberin, therefore preventing its ubiquitination and degradation in the proteasome. Alternative splicing results in multiple transcript variants encoding different isoforms of the protein. Mutations in TSC2 can cause Lymphangioleiomyomatosis, a disease caused by the enlargement of tissue in the lungs, creating cysts and tumours and causing difficulty breathing. Because tuberin regulates cell size, along with the protein hamartin, mutations to TSC1 and TSC2 genes may prevent the control of cell growth in the lungs of individuals. Cell pathology Cells from individuals with pathogenic mutations in the TSC2 gene display ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosphatidylinositol
Phosphatidylinositol or inositol phospholipid is a biomolecule. It was initially called "inosite" when it was discovered by Léon Maquenne and Johann Joseph von Scherer in the late 19th century. It was discovered in bacteria but later also found in eukaryotes, and was found to be a signaling molecule. The biomolecule can exist in 9 different isomers. It is a lipid which contains a phosphate group, two fatty acid chains, and one inositol sugar molecule. Typically, the phosphate group has a negative charge (at physiological pH values). As a result, the molecule is amphiphilic. The production of the molecule is limited to the endoplasmic reticulum. History of phospatidylinositol Phosphatidylinositol (PI) and its derivatives have a rich history dating back to their discovery by Johann Joseph von Scherer and Léon Maquenne in the late 19th century. Initially known as " inosite" based on its sweet taste, the isolation and characterization of inositol laid the groundwork for und ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vicki Sato
Vicki L. Sato is a retired professor of management practice at Harvard Business School and a professor of the practice in the department of molecular and cell biology at Harvard University. Since 2021, she has been a member of the President’s Council of Advisors on Science and Technology (PCAST). Background and career She earned her A.B. in biology from Radcliffe College and her A.M. and Ph.D. (1972) in biology from Harvard University focusing on the genetics of photosynthesis under the guidance of Paul Levine. She then did her postdoctoral work at University of California, Berkeley with Kenneth Sauer and Stanford Medical Center with Leonard Herzenberg where she shifted fields from biophysics into immunology. Initially, she returned to Harvard as a professor in the Department of Cell and Developmental Biology. During that time, she co-taught immunology with Walter Gilbert who was beginning to found Biogen Inc. along with Phil Sharp, Charles Weissmann, and Kenneth Murray. Du ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dana–Farber Cancer Institute
Dana–Farber Cancer Institute (DFCI) is a comprehensive cancer treatment and research center in Boston, Massachusetts. Dana-Farber is the founding member of the Dana-Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated by the National Cancer Institute, and one of the 15 clinical affiliates and research institutes of Harvard Medical School. As of 2024, Dana-Farber is ranked the #6 cancer hospital in the US. Two Nobel Prize in Physiology or Medicine, Nobel laureates in Physiology or Medicine are among its past and present faculty. In 2024, an investigation revealed evidence of scientific misconduct, research misconduct in dozens of studies authored by Dana-Farber researchers, including then President (corporate title), President and Chief executive officer, CEO Laurie Glimcher, the Vice President, Executive Vice President and Chief operating officer, COO, and the Scientific integrity, Research Integrity Officer. In response to these findings, Dana-Farber ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NewYork–Presbyterian Hospital
The NewYork-Presbyterian Hospital (abbreviated as NYP) is a nonprofit academic medical center in New York City. It is the primary teaching hospital for Weill Cornell Medicine and Columbia University College of Physicians and Surgeons. The hospital includes seven campuses located throughout the New York metropolitan area. The hospital's two flagship medical centers, Columbia University Irving Medical Center and Weill Cornell Medical Center, are located on opposite sides of Upper Manhattan. , the hospital is ranked the seventh-best hospital in the United States and second-best in the New York City metropolitan area by '' U.S. News & World Report''. The hospital has more than 6,500 affiliated physicians, 20,000 employees and operates 4,000+ beds in total. It is one of the largest hospitals in the world. NYPH annually treats about 310,000 patients in its emergency department and delivers about 15,000 babies. History NewYork-Presbyterian Hospital was founded in 1771 as New Y ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tufts University School Of Medicine
The Tufts University School of Medicine is the medical school of Tufts University, a Private university, private research university in Massachusetts. It was established in 1893 and is located on the university's health sciences campus in downtown Boston. It has clinical affiliations with numerous doctors and researchers in the United States and around the world, as well as with its affiliated hospitals in both Massachusetts (including Tufts Medical Center, St. Elizabeth's Medical Center (Boston), St. Elizabeth's Medical Center, Lahey Hospital & Medical Center, Lahey Hospital and Medical Center and Baystate Medical Center), and Maine (Maine Medical Center). History The School of Medicine was established by vote of the Trustees of Tufts College on April 22, 1893. It was formed by the secession of seven faculty from the College of Physicians and Surgeons in Boston, a school which was formed in 1880. These "original seven" faculty members successfully lobbied to establish a medic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transition State Analog
Transition state analogs (transition state analogues), are chemical compounds with a chemical structure that resembles the transition state of a substrate molecule in an enzyme-catalyzed chemical reaction. Enzymes interact with a substrate by means of strain or distortions, moving the substrate towards the transition state. Transition state analogs can be used as inhibitors in enzyme-catalyzed reactions by blocking the active site of the enzyme. Theory suggests that enzyme inhibitors which resembled the transition state structure would bind more tightly to the enzyme than the actual substrate. Examples of drugs that are transition state analog inhibitors include flu medications such as the neuraminidase inhibitor oseltamivir and the HIV protease inhibitors saquinavir in the treatment of AIDS. Transition state analogue The transition state of a structure can best be described in regards to statistical mechanics where the energies of bonds breaking and forming have an equa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vanadate
In chemistry, a vanadate is an anionic coordination complex of vanadium. Often vanadate refers to oxoanions of vanadium, most of which exist in its highest oxidation state of +5. The complexes and are referred to as hexacyanovanadate(III) and nonachlorodivanadate(III), respectively. A simple vanadate ion is the tetrahedral orthovanadate anion, (which is also called vanadate(V)), which is present in e.g. sodium orthovanadate and in solutions of vanadium pentoxide, in strong base (pH > 13). Conventionally this ion is represented with a single double bond, however this is a resonance (chemistry), resonance form as the ion is a regular tetrahedron with four equivalent oxygen atoms. Additionally a range of polyoxovanadate ions exist which include discrete ions and "infinite" polymeric ions. There are also vanadates, such as rhodium vanadate, , which has a statistical titanium dioxide, rutile structure where the and ions randomly occupy the positions in the rutile latti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
