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Lee Altenberg
Lee Altenberg is an American theoretical biologist. He is on the faculty of the Departments of Information and Computer Sciences and of Mathematics at the University of Hawaiʻi at Mānoa. He is best known for his work that helped establish the evolution of evolvability and modularity in the genotype–phenotype map as areas of investigation in evolutionary biology, for moving theoretical concepts between the fields of evolutionary biology and evolutionary computation, and for his mathematical unification and generalization of modifier gene models for the evolution of biological information transmission, putting under a single mathematical framework the evolution of mutation rates, recombination rates, sexual reproduction rates, and dispersal rates. Altenberg is an associate editor of the journal '' BioSystems'', and serves on the editorial boards of the journals '' Genetic Programming and Evolvable Machines'' and ''Artificial Life'', and on the IEEE Computational Intelligenc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Sciences
Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, origin, evolution, and distribution of life. Central to biology are five fundamental themes: the cell as the basic unit of life, genes and heredity as the basis of inheritance, evolution as the driver of biological diversity, energy transformation for sustaining life processes, and the maintenance of internal stability (homeostasis). Biology examines life across multiple levels of organization, from molecules and cells to organisms, populations, and ecosystems. Subdisciplines include molecular biology, physiology, ecology, evolutionary biology, developmental biology, and systematics, among others. Each of these fields applies a range of methods to investigate biological phenomena, including observation, experimentation, and mathematical modeling. Modern biology is grounded i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IEEE Computational Intelligence Society
The Institute of Electrical and Electronics Engineers (IEEE) is an American 501(c)(3) public charity professional organization for electrical engineering, electronics engineering, and other related disciplines. The IEEE has a corporate office in New York City and an operations center in Piscataway, New Jersey. The IEEE was formed in 1963 as an amalgamation of the American Institute of Electrical Engineers and the Institute of Radio Engineers. History The IEEE traces its founding to 1884 and the American Institute of Electrical Engineers. In 1912, the rival Institute of Radio Engineers was formed. Although the AIEE was initially larger, the IRE attracted more students and was larger by the mid-1950s. The AIEE and IRE merged in 1963. The IEEE is headquartered in New York City, but most business is done at the IEEE Operations Center in Piscataway, New Jersey, opened in 1975. The Australian Section of the IEEE existed between 1972 and 1985, after which it split into state- and t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modularity
Modularity is the degree to which a system's components may be separated and recombined, often with the benefit of flexibility and variety in use. The concept of modularity is used primarily to reduce complexity by breaking a system into varying degrees of interdependence and independence across and "hide the complexity of each part behind an abstraction and interface". However, the concept of modularity can be extended to multiple disciplines, each with their own nuances. Despite these nuances, consistent themes concerning modular systems can be identified. Composability is one of the tenets of functional programming. This makes functional programs modular. Contextual nuances The meaning of the word "modularity" can vary somewhat based on context. The following are contextual examples of modularity across several fields of science, technology, industry, and culture: Science *In biology, modularity recognizes that organisms or metabolic pathways are composed of modules. *I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Variational Properties
In evolutionary biology, the variational properties of an organism are those properties relating to the production of variation among its offspring. In a broader sense variational properties include phenotypic plasticity. Wagner, G. P. and Altenberg, L. 1996. Complex adaptations and the evolution of evolvability. ''Evolution'' 50 (3): 967-976. Variational properties contrast with functional properties. While the functional properties of an organism determine is level of adaptedness to its environment, it is the variational properties of the organisms in a species that chiefly determine its evolvability and genetic robustness. Variational properties group together many classical and more recent concepts of evolutionary biology. It includes the classical concepts of pleiotropy, canalization, developmental constraints, developmental bias, morphological integration, developmental homeostasis and later concepts such as robustness, neutral networks, modularity Modularity is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Information
A nucleic acid sequence is a succession of Nucleobase, bases within the nucleotides forming alleles within a DNA (using GACT) or RNA (GACU) molecule. This succession is denoted by a series of a set of five different letters that indicate the order of the nucleotides. By convention, sequences are usually presented from the Directionality (molecular biology), 5' end to the 3' end. For DNA, with its double helix, there are two possible directions for the notated sequence; of these two, the Sense (molecular biology), sense strand is used. Because nucleic acids are normally linear (unbranched) polymers, specifying the sequence is equivalent to defining the covalent structure of the entire molecule. For this reason, the nucleic acid sequence is also termed the Biomolecular structure#Primary structure, primary structure. The sequence represents genetic information. Biological deoxyribonucleic acid represents the information which directs the functions of an organism. Nucleic acids also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evolvability
Evolvability is defined as the capacity of a system for adaptive evolution. Evolvability is the ability of a population of organisms to not merely generate genetic diversity, but to generate '' adaptive'' genetic diversity, and thereby evolve through natural selection. In order for a biological organism to evolve by natural selection, there must be a certain minimum probability that new, heritable variants are beneficial. Random mutations, unless they occur in DNA sequences with no function, are expected to be mostly detrimental. Beneficial mutations are always rare, but if they are too rare, then adaptation cannot occur. Early failed efforts to evolve computer programs by random mutation and selection showed that evolvability is not a given, but depends on the representation of the program as a data structure, because this determines how changes in the program map to changes in its behavior. Analogously, the evolvability of organisms depends on their genotype–phenotype map. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evolutionary Algorithms
Evolutionary algorithms (EA) reproduce essential elements of the biological evolution in a computer algorithm in order to solve "difficult" problems, at least Approximation, approximately, for which no exact or satisfactory solution methods are known. They belong to the class of Metaheuristic, metaheuristics and are a subset of Population Based Bio-Inspired Algorithms, population based bio-inspired algorithms and evolutionary computation, which itself are part of the field of computational intelligence. The mechanisms of biological evolution that an EA mainly imitates are reproduction, mutation, genetic recombination, recombination and natural selection, selection. Candidate solutions to the optimization problem play the role of individuals in a population, and the fitness function determines the quality of the solutions (see also loss function). Evolution of the population then takes place after the repeated application of the above operators. Evolutionary algorithms often perfor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Hawaiʻi
The University of Hawaiʻi System is a public college and university system in Hawaii. The system confers associate, bachelor's, master's, and doctoral degrees through three universities, seven community colleges, an employment training center, three university centers, four education centers, and various other research facilities distributed across six islands throughout the state of Hawaii. All schools in the University of Hawaiʻi System are accredited by the Western Association of Schools and Colleges. The system's main administrative offices are located on the property of the University of Hawaiʻi at Mānoa in Honolulu. History The University of Hawai'i System was created in 1965, combining the State of Hawai'i's technical and community colleges into a single system within the former University of Hawaiʻi. The original University of Hawaiʻi was established by the Territory of Hawaiʻi in 1907 as a land-grant college for agriculture and mechanical arts, holding its f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ohio State University
The Ohio State University (Ohio State or OSU) is a public university, public Land-grant university, land-grant research university in Columbus, Ohio, United States. A member of the University System of Ohio, it was founded in 1870. It is one of the List of largest United States university campuses by enrollment, largest universities by enrollment in the United States, with nearly 50,000 undergraduate students and nearly 15,000 graduate students. The university consists of sixteen colleges and offers over 400 degree programs at the undergraduate and Graduate school, graduate levels. It is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity". the university has an List of colleges and universities in the United States by endowment, endowment of $7.9 billion. Its athletic teams compete in NCAA Division I as the Ohio State Buckeyes as a member of the Big Ten Conference for the majority of fielde ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mathematical Biosciences Institute
The Mathematical Biosciences Institute (MBI) was an institution of higher learning affiliated with the Ohio State University in Columbus, Ohio. MBI received major funding from the National Science Foundation. History Under the leadership of founding director Avner Friedman, MBI opened in September 2002, holding its first workshop, hosting its first visiting researchers, and starting its first cohort of postdocs in that month. MBI holds 10–12 scientific workshops each year, and hosts about 25 postdoctoral and visiting researchers in residence at any given time. Through its collective events and programs, MBI draws over 1000 visits by researchers in the broadly defined area of mathematical biology throughout the year. MBI's long term planning is overseen by its Directorate and its Board of Trustees, while its scientific activities are overseen by its Directorate and its Scientific Advisory Committee. MBI programs Workshops MBI organizes Emphasis Semesters consisting of three o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hawaii
Hawaii ( ; ) is an island U.S. state, state of the United States, in the Pacific Ocean about southwest of the U.S. mainland. One of the two Non-contiguous United States, non-contiguous U.S. states (along with Alaska), it is the only state not on the North American mainland, the only state that is an archipelago, and the only state in the tropics. Hawaii consists of 137 volcanic islands that comprise almost the entire Hawaiian Islands, Hawaiian archipelago (the exception, which is outside the state, is Midway Atoll). Spanning , the state is Physical geography, physiographically and Ethnology, ethnologically part of the Polynesian subregion of Oceania. Hawaii's ocean coastline is consequently the List of U.S. states and territories by coastline, fourth-longest in the U.S., at about . The eight main islands, from northwest to southeast, are Niihau, Niihau, Kauai, Kauai, Oahu, Oahu, Molokai, Molokai, Lanai, Lānai, Kahoʻolawe, Kahoolawe, Maui, and Hawaii (island), Hawaii, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cold Sensitive Antibodies
Cold sensitive antibodies (CSA) are antibodies sensitive to cold temperature. Some cold sensitive antibodies are pathological and can lead to blood disorder. These pathological cold sensitive antibodies include cold agglutinins, Donath–Landsteiner antibodies, and cryoglobulins which are the culprits of cold agglutinin disease, paroxysmal cold hemoglobinuria in the process of Donath–Landsteiner hemolytic anemia, and vasculitis, respectively. Cold agglutinin antibodies Cold agglutinins are antibodies, typically immunoglobulin M ( IgM), that are acquainted with and then binding the antigens on red blood cells, typically antigens "I" or "i" on the RBC surface, in the environment in which the temperatures are lower than normal core body temperature and, thus, ends up leading to agglutinations of the red blood cells and hemolysis reaction occurring outside the vessels (extra-vessels), resulting in anemia without hemoglobinuria in ordinary cases. Cold agglutinins can cause ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
