Karl Broman
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Karl Broman
Karl Broman is a professor at the University of Wisconsin–Madison (UWM) in the Biostatistics and Medical Informatics departments. He has been employed at UWM since 2007 and previously was employed at Johns Hopkins University from 1999 - 2007. Broman's original research focus was quantitative genetics, although he has also become known for his work on reproducible research. In 2016, Broman was named a Fellow of the American Statistical Association. Research Study of Bile Acids In 2019 Karl Broman and a group of researchers published a study which found genetic variants in mice that impacted the bile acid levels in their guts. Broman's other highly cited papers include: * Broman, Karl W., et al. "Comprehensive human genetic maps: individual and sex-specific variation in recombination." ''The American Journal of Human Genetics'' 63.3 (1998): 861–869. * Broman, Karl W., et al. "R/qtl: QTL mapping in experimental crosses." ''Bioinformatics'' 19.7 (2003): 889–890. * Churchi ...
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University Of Wisconsin–Madison
The University of Wisconsin–Madison (University of Wisconsin, Wisconsin, UW, UW–Madison, or simply Madison) is a public land-grant research university in Madison, Wisconsin, United States. It was founded in 1848 when Wisconsin achieved statehood and is the flagship campus of the University of Wisconsin System. The main campus is located on the shores of Lake Mendota; the university also owns and operates a arboretum south of the main campus. UW–Madison is organized into 13 schools and colleges, which enrolled approximately 34,200 undergraduate and 14,300 graduate and professional students in 2024. Its academic programs include 136 undergraduate majors, 148 master's degree programs, and 120 doctoral programs. Wisconsin is one of the founding members of the Association of American Universities. It is considered a Public Ivy and is classified as an R1 University. UW–Madison was also the home of both the prominent "Wisconsin School" of economics and diplomatic h ...
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Biostatistics
Biostatistics (also known as biometry) is a branch of statistics that applies statistical methods to a wide range of topics in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experiments and the interpretation of the results. History Biostatistics and genetics Biostatistical modeling forms an important part of numerous modern biological theories. Genetics studies, since its beginning, used statistical concepts to understand observed experimental results. Some genetics scientists even contributed with statistical advances with the development of methods and tools. Gregor Mendel started the genetics studies investigating genetics segregation patterns in families of peas and used statistics to explain the collected data. In the early 1900s, after the rediscovery of Mendel's Mendelian inheritance work, there were gaps in understanding between genetics and evolutionary Darwinism. Francis Galton tried to expand Mendel's ...
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Johns Hopkins University
The Johns Hopkins University (often abbreviated as Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland, United States. Founded in 1876 based on the European research institution model, Johns Hopkins is considered to be the first research university in the U.S. The university was named for its first benefactor, the American entrepreneur and Quakers, Quaker philanthropist Johns Hopkins. Hopkins's $7 million bequest (equivalent to $ in ) to establish the university was the largest Philanthropy, philanthropic gift in U.S. history up to that time. Daniel Coit Gilman, who was inaugurated as :Presidents of Johns Hopkins University, Johns Hopkins's first president on February 22, 1876, led the university to revolutionize higher education in the U.S. by integrating teaching and research. In 1900, Johns Hopkins became a founding member of the Association of American Universities. The university has led all Higher education in the U ...
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Quantitative Genetics
Quantitative genetics is the study of quantitative traits, which are phenotypes that vary continuously—such as height or mass—as opposed to phenotypes and gene-products that are Categorical variable, discretely identifiable—such as eye-colour, or the presence of a particular biochemical. Both of these branches of genetics use the frequencies of different alleles of a gene in breeding populations (gamodemes), and combine them with concepts from simple Mendelian inheritance to analyze inheritance patterns across generations and descendant lines. While population genetics can focus on particular genes and their subsequent metabolic products, quantitative genetics focuses more on the outward phenotypes, and makes only summaries of the underlying genetics. Due to the continuous distribution of phenotypic values, quantitative genetics must employ many other statistical methods (such as the ''effect size'', the ''mean'' and the ''variance'') to link phenotypes (attributes) to gen ...
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American Statistical Association
The American Statistical Association (ASA) is the main professional organization for statisticians and related professionals in the United States. It was founded in Boston, Massachusetts, on November 27, 1839, and is the second-oldest continuously operating professional society in the U.S. behind the Massachusetts Medical Society (founded in 1781). ASA services statisticians, quantitative scientists, and users of statistics across many academic areas and applications. The association publishes a variety of journals and sponsors several international conferences every year. Mission The organization's mission is to promote good application of statistical science, specifically to: * support excellence in statistical practice, research, journals, and meetings * work for the improvement of statistical education at all levels * promote the proper application of statistics * anticipate and meet member needs * use the discipline of statistics to enhance human welfare * seek opportunities ...
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Bile Acid
Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates. Diverse bile acids are synthesized in the liver in peroxisomes. Bile acids are conjugated with taurine or glycine residues to give anions called bile salts. Primary bile acids are those synthesized by the liver. Secondary bile acids result from bacterial actions in the colon. In humans, taurocholic acid and glycocholic acid (derivatives of cholic acid) and taurochenodeoxycholic acid and glycochenodeoxycholic acid (derivatives of chenodeoxycholic acid) are the major bile salts. The salts of their 7-alpha-dehydroxylated derivatives, deoxycholic acid and lithocholic acid, are also found, with derivatives of cholic, chenodeoxycholic and deoxycholic acids accounting for over 90% of human biliary bile acids. Description Bile acids comprise about 80% of the organic compounds in bile (others are phospholipids and cholesterol). An increased secretion of bile acids produces an increase ...
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R (programming Language)
R is a programming language for statistical computing and Data and information visualization, data visualization. It has been widely adopted in the fields of data mining, bioinformatics, data analysis, and data science. The core R language is extended by a large number of R package, software packages, which contain Reusability, reusable code, documentation, and sample data. Some of the most popular R packages are in the tidyverse collection, which enhances functionality for visualizing, transforming, and modelling data, as well as improves the ease of programming (according to the authors and users). R is free and open-source software distributed under the GNU General Public License. The language is implemented primarily in C (programming language), C, Fortran, and Self-hosting (compilers), R itself. Preprocessor, Precompiled executables are available for the major operating systems (including Linux, MacOS, and Microsoft Windows). Its core is an interpreted language with a na ...
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Year Of Birth Missing (living People)
A year is a unit of time based on how long it takes the Earth to orbit the Sun. In scientific use, the tropical year (approximately 365 solar days, 5 hours, 48 minutes, 45 seconds) and the sidereal year (about 20 minutes longer) are more exact. The modern calendar year, as reckoned according to the Gregorian calendar, approximates the tropical year by using a system of leap years. The term 'year' is also used to indicate other periods of roughly similar duration, such as the lunar year (a roughly 354-day cycle of twelve of the Moon's phasessee lunar calendar), as well as periods loosely associated with the calendar or astronomical year, such as the seasonal year, the fiscal year, the academic year, etc. Due to the Earth's axial tilt, the course of a year sees the passing of the seasons, marked by changes in weather, the hours of daylight, and, consequently, vegetation and soil fertility. In temperate and subpolar regions around the planet, four seasons a ...
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Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ...
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American Biostatisticians
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University, in Washington, D.C. Sports teams S ...
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R (programming Language) People
R, or r, is the eighteenth letter of the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is ''ar'' (pronounced ), plural ''ars''. The letter is the eighth most common letter in English and the fourth-most common consonant, after , , and . Name The name of the letter in Latin was (), following the pattern of other letters representing continuants, such as , , , , and . This name is preserved in French and many other languages. In Middle English, the name of the letter changed from to , following a pattern exhibited in many other words such as ''farm'' (compare French ) and ''star'' (compare German ). In Hiberno-English, the letter is called or , somewhat similar to ''oar'', ''ore'', ''orr''. The letter R is sometimes referred to as the 'canine letter', often rendered in English as the dog's letter. This Latin term referred to the Latin that was trilled to sound li ...
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Fellows Of The American Statistical Association
Like many other academic professional societies, the American Statistical Association (ASA) uses the title of Fellow of the American Statistical Association as its highest honorary grade of membership. The designation of ASA Fellow has been a significant honor for nearly 100 years. The number of new fellows per year is limited to one third of one percent of the membership of the ASA. To be selected, nominees must have an established reputation and have made outstanding contributions to statistical science. People named as Fellows are listed below. Fellows 1914 * John Lee Coulter * Miles Menander Dawson * Frank H. Dixon * David Parks Fackler * Henry Walcott Farnam * Charles Ferris Gettemy * Franklin Henry Giddings * Henry J. Harris * Edward M. Hartwell * Joseph A. Hill * George K. Holmes * William Chamberlin Hunt * John Koren * Thomas Bassett Macaulay * S. N. D. North * Warren M. Persons * Edward B. Phelps * LeGrand Powers * William Sidney Rossiter * Charles H. Verrill ...
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