Karl Broman is a professor at the

University of Wisconsin–Madison The University of Wisconsin–Madison (University of Wisconsin, Wisconsin, UW, UW–Madison, or simply Madison) is a public land-grant research university in Madison, Wisconsin, United States. It was founded in 1848 when Wisconsin achieved st ...

(UWM) in the

Biostatistics Biostatistics (also known as biometry) is a branch of statistics that applies statistical methods to a wide range of topics in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experimen ...

and Medical Informatics departments. He has been employed at UWM since 2007 and previously was employed at

Johns Hopkins University The Johns Hopkins University (often abbreviated as Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland, United States. Founded in 1876 based on the European research institution model, J ...

from 1999 - 2007. Broman's original research focus was

quantitative genetics Quantitative genetics is the study of quantitative traits, which are phenotypes that vary continuously—such as height or mass—as opposed to phenotypes and gene-products that are Categorical variable, discretely identifiable—such as eye-col ...

, although he has also become known for his work on reproducible research. In 2016, Broman was named a Fellow of the

American Statistical Association The American Statistical Association (ASA) is the main professional organization for statisticians and related professionals in the United States. It was founded in Boston, Massachusetts, on November 27, 1839, and is the second-oldest continuous ...

Research

Study of Bile Acids

In 2019 Karl Broman and a group of researchers published a study which found genetic variants in mice that impacted the

bile acid Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates. Diverse bile acids are synthesized in the liver in peroxisomes. Bile acids are conjugated with taurine or glycine residues to give anions called bile ...

levels in their guts. Broman's other highly cited papers include: * Broman, Karl W., et al. "Comprehensive human genetic maps: individual and sex-specific variation in recombination." ''The American Journal of Human Genetics'' 63.3 (1998): 861–869. * Broman, Karl W., et al. "R/qtl: QTL mapping in experimental crosses." ''Bioinformatics'' 19.7 (2003): 889–890. * Churchill, Gary A., et al. "The Collaborative Cross, a community resource for the genetic analysis of complex traits." ''Nature genetics'' 36.11 (2004): 1133.

Rstudio

Karl Broman created

R (programming language) R is a programming language for statistical computing and Data and information visualization, data visualization. It has been widely adopted in the fields of data mining, bioinformatics, data analysis, and data science. The core R language is ...

packages such as qtlcharts, QTL, and QTL2. These packages perform trait localization and visualizations of genetic data in high dimensions.

References

{{DEFAULTSORT:Broman, Karl Year of birth missing (living people) Living people American biostatisticians R (programming language) people Fellows of the American Statistical Association Johns Hopkins University alumni University of Wisconsin–Madison faculty