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John Stith Pemberton
John Stith Pemberton (July 8, 1831 – August 16, 1888) was an American pharmacist and Confederate States Army veteran who is best known as the inventor of Coca-Cola. On May 8, 1886, he developed an early version of a beverage that would later become Coca-Cola, but sold the rights to the drink shortly before his death in 1888. He suffered from a sabre wound sustained in April 1865, during the Battle of Columbus. His efforts to control his chronic pain led to morphine addiction. In an attempt to curb his addiction he began to experiment with various painkillers and toxins. The development of an earlier beverage blending alcohol and cocaine led to the recipe that later was adapted to make Coca-Cola. Background Pemberton was born on July 8, 1831, in Knoxville, Georgia, and spent most of his childhood in Rome, Georgia. His parents were James C. Pemberton and Martha L. Gant. Pemberton entered the Reform Medical College of Georgia in Macon, Georgia, and in 1850, at the age of nin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Knoxville, Georgia
Knoxville is an unincorporated community and census-designated place in Crawford County, Georgia, United States. It is the county seat of Crawford County. The community is part of the Macon metropolitan area. As of the 2020 census, Knoxville had a population of 65. Knoxville was founded in 1823 as seat of the newly formed Crawford County. It was incorporated as a town in 1825. The former city's municipal charter was dissolved in 1995 pursuant to a Georgia law which abolished city governments which were defunct or minimally operative. There are three National Register of Historic Places in Knoxville, which are the Crawford County Courthouse, the Crawford County Jail, and the Georgia Post Building. History Naming There is confusion as to whom Knoxville was named for. Historians who rely on old records and spoken traditions have pointed to General Henry Knox, who served in the Continental Army under George Washington, though General Knox had no ties to the state of Georgia, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Columbus, Georgia
Columbus is a consolidated city-county located on the west-central border of the U.S. state of Georgia (U.S. state), Georgia. Columbus lies on the Chattahoochee River directly across from Phenix City, Alabama. It is the county seat of Muscogee County, Georgia, Muscogee County, with which it officially merged in 1970; the original merger excluded Bibb City, Georgia, Bibb City, which joined in 2000 after dissolving its own city charter. Columbus is the List of municipalities in Georgia (U.S. state), second most populous city in Georgia (after Atlanta), and fields the state's List of metropolitan areas in Georgia (U.S. state), fourth-largest metropolitan area. At the 2020 United States census, 2020 U.S. census, Columbus had a population of 206,922, with 328,883 in the Columbus, Georgia metropolitan area, Columbus metropolitan statistical area. The metro area joins the nearby Alabama cities of Auburn, Alabama, Auburn and Opelika, Alabama, Opelika to form the Columbus–Auburn–Ope ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pemberton's French Wine Coca
Pemberton's French Wine Coca was a coca wine created by the druggist John Pemberton, the inventor of Coca-Cola. It was an alcoholic beverage, mixed with coca, kola nut, and damiana. The original recipe contained the ingredient cocaethylene (cocaine mixed with alcohol), which was removed, just like the alcohol had before it, in 1899 because of a social stigma surrounding the rampant use of cocaine at the time. History French wine coca is a combination of cocaethylene (a unique drug made by mixing cocaine and alcohol) and French wine. In 1863, a Corsican chemist Angelo Mariani combined coca and wine and started selling it under the name " Vin Mariani". This became extremely popular. Jules Verne, Alexander Dumas, and Arthur Conan Doyle were among literary figures said to have used it, and the chief rabbi of France is quoted to have said, "Praise be to Mariani's wine!" Pope Leo XIII reportedly carried a flask of it regularly and gave Mariani a medal. Seeing this commerci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Turnera Diffusa
''Turnera diffusa'', known as damiana, is a shrub native to southern Texas in the United States, Mexico, Central America, South America, and the Caribbean. It belongs to the family Passifloraceae. Damiana is a relatively small, woody shrub that produces small, aromatic flowers. It blossoms in early to late summer, followed by fruits that taste similar to figs. The shrub is said to have a strong spice-like odor somewhat like chamomile, due to the aromatic compounds present in the plant. Damiana is traditionally used in Mexico, Mexican Liqueur, liqueurs and Margarita, margaritas, historically featured in 19th-century Patent medicine, patent medicines as an alleged aphrodisiac, and today is valued in Herbal tea, herbal teas and smoking blends for its Anxiolytic, calming and mild Psychoactive drug, psychoactive effects. It contains a complex mix of Phytochemical, phytochemicals—including Flavonoid, flavonoids like apigenin and acacetin, Terpenoid, terpenoids, Phenolic content in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kola Nut
The kola nut ( Yoruba: ''obi'', Dagbani: ''guli'', Hausa: goro, Igbo: ''ọjị'', Sängö: ''gôro,'' Swahili: ''mukezu'') is the seed of certain species of plant of the genus ''Cola'', placed formerly in the cocoa family Sterculiaceae and now usually subsumed in the mallow family Malvaceae (as subfamily Sterculioideae). These cola species are trees native to the tropical rainforests of Africa. Their caffeine-containing seeds are used as flavoring ingredients in various carbonated soft drinks, from which the name ''cola'' originates. Description About across, the kola nut is a nut of evergreen trees of the genus ''Cola'', primarily of the species ''Cola acuminata'' and '' Cola nitida''. ''Cola acuminata'', an evergreen tree about 20 meters in height, has long, ovoid leaves pointed at both the ends with a leathery texture. The trees have cream-white flowers with purplish-brown striations, and star-shaped fruit consisting of usually 5 follicles. Inside each follicle, ab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coca Wine
Coca wine is an alcoholic beverage combining wine with cocaine. One popular brand was '' Vin Mariani'', developed in 1863 by French chemist and entrepreneur Angelo Mariani. At the end of the 19th century, the fear of drug abuse made coca-based drinks less popular. This led to the prohibition of cocaine in the United States in 1914 via the Harrison Narcotics Tax Act, and the removal of cocaine from coca wine, though coca leaf remained. Coca wine itself became illegal in the United States when its other main drug, alcohol, was banned just a few years later with the Eighteenth Amendment in 1920. Related beverages In Atlanta, John Pemberton, a pharmacist, developed a beverage based on Vin Mariani, called Pemberton's French Wine Coca. It proved popular among American consumers. In 1886, when Georgia introduced Prohibition, Pemberton had to replace the wine in his recipe with non-alcoholic syrup. The new recipe became Coca-Cola Coca-Cola, or Coke, is a cola soft drink ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coca
Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. Coca is known worldwide for its psychoactive alkaloid, cocaine. Coca leaves contain cocaine which acts as a mild stimulant when chewed or consumed as tea, with slower absorption than purified cocaine and no evidence of addiction or withdrawal symptoms from natural use. The coca plant is a shrub-like bush with curved branches, oval leaves featuring distinct curved lines, small yellowish-white flowers that develop into red berries. Genomic analysis reveals that coca, a culturally and economically important plant, was domesticated two or three separate times from the wild species ''Erythroxylum gracilipes'' by different South American groups during the Holocene. Chewing coca in South America began at least 8,000 years ago, as evidenced by coca leaves and calcite found in house floors in Peru’s Nanchoc Valley, suggesting early communal use alongside the rise of farming. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxin
A toxin is a naturally occurring poison produced by metabolic activities of living cells or organisms. They occur especially as proteins, often conjugated. The term was first used by organic chemist Ludwig Brieger (1849–1919), derived from '' toxic''. Toxins can be small molecules, peptides, or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors. They vary greatly in their toxicity, ranging from usually minor (such as a bee sting) to potentially fatal even at extremely low doses (such as botulinum toxin). Terminology Toxins are often distinguished from other chemical agents strictly based on their biological origin. Less strict understandings embrace naturally occurring inorganic toxins, such as arsenic. Other understandings embrace synthetic analogs of naturally occurring organic poisons as toxins, and may or may not embrace naturally oc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cephalanthus Occidentalis
''Cephalanthus occidentalis'' is a species of flowering plant in the family Rubiaceae that is native to eastern and southern North America. Common names include buttonbush, common buttonbush, button-willow, buck brush, and honey-bells. Description ''Cephalanthus occidentalis'' is a deciduous shrub or small tree that averages in height, but can reach . The leaf, leaves are opposite or in whorls of three, elliptic to ovate, long and broad, with a smooth edge and a short Petiole (botany), petiole. The flowers are arranged in a dense spherical inflorescence in diameter on a short Peduncle (botany), peduncle. Each flower has a fused white to pale yellow four-lobed Corolla (flower), corolla forming a long slender tube connecting to the sepals. The gynoecium, stigma protrudes slightly from the corolla. The fruit is a spherical cluster of achenes (nutlets). File:Cephalanthus occidentalis 15-p.bot-cepha.occi-08.jpg, Leaves opposite or in whorls of three; inflorescences may be in clus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opium
Opium (also known as poppy tears, or Lachryma papaveris) is the dried latex obtained from the seed Capsule (fruit), capsules of the opium poppy ''Papaver somniferum''. Approximately 12 percent of opium is made up of the analgesic alkaloid morphine, which is processed chemically to produce heroin and other synthetic opioids for medicinal use and for the illegal drug trade. Opium's main psychoactive alkaloids, primarily morphine, act on μ-opioid receptors, causing analgesia and addiction with long-term use leading to tolerance, dependence, and increased cancer risk. The latex also contains the closely related opiates codeine and thebaine, and non-analgesic alkaloids such as papaverine and noscapine. The traditional, labor-intensive method of obtaining the latex is to scratch ("score") the immature seed pods (fruits) by hand; the latex leaks out and dries to a sticky yellowish residue that is later scraped off and dehydrated. The English word for opium is loan word, borrowed fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morphine
Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (''Papaver somniferum''). It is mainly used as an analgesic (pain medication). There are multiple methods used to administer morphine: oral; sublingual administration, sublingual; via inhalation; intramuscular, injection into a muscle, Subcutaneous injection, injection under the skin, or injection into the spinal cord area; transdermal; or via rectal administration, rectal suppository. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and emotional response to pain. Physical and psychological dependence and tolerance may develop with repeated administration. It can be taken for both acute pain and chronic pain and is frequently used for pain from myocardial infarction, kidney stones, and during Childbirth, labor. Its maximum effect is reached after about 20 minutes when administ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Register Of Historic Places
The National Register of Historic Places (NRHP) is the Federal government of the United States, United States federal government's official United States National Register of Historic Places listings, list of sites, buildings, structures, Historic districts in the United States, districts, and objects deemed worthy of Historic preservation, preservation for their historical significance or "great artistic value". The enactment of the National Historic Preservation Act (NHPA) in 1966 established the National Register and the process for adding properties to it. Of the more than one and a half million properties on the National Register, 95,000 are listed individually. The remainder are contributing property, contributing resources within historic district (United States), historic districts. For the most of its history, the National Register has been administered by the National Park Service (NPS), an agency within the United States Department of the Interior. Its goals are to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
