|
Isoniazid
Isoniazid, also known as isonicotinic acid hydrazide (INH), is an antibiotic used for the treatment of tuberculosis. For active tuberculosis, it is often used together with rifampicin, pyrazinamide, and either streptomycin or ethambutol. For latent tuberculosis, it is often used alone. It may also be used for atypical types of mycobacteria, such as '' M. avium'', '' M. kansasii'', and '' M. xenopi''. It is usually taken by mouth, but may be used by injection into muscle. History After F. Raschig developed a method to synthesize hydrazine, Hans Meyer and his doctoral student at the German University in Prague Josef Mally studied hydrazides of pyridinecarboxylic acids. By reacting ethyl isonicotinate with hydrazine hydrate they obtained a compound which, after a recrystallization, had a melting point of 163°C. Despite their results published in 1912, its pharmaceutical properties weren't investigated for decades. In the 1940s French physicians discovered that nicotina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tuberculosis Management
Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB. The medical standard for active TB is a short course treatment involving a combination of isoniazid, rifampicin (also known as Rifampin), pyrazinamide, and ethambutol for the first two months. During this initial period, Isoniazid is taken alongside pyridoxal phosphate to obviate peripheral neuropathy. Isoniazid is then taken concurrently with rifampicin for the remaining four months of treatment (6-8 months for miliary tuberculosis). A patient is expected to be free from all living TB bacteria after six months of therapy in Pulmonary TB or 8-10 months in Miliary TB. Latent tuberculosis or latent tuberculosis infection (LTBI) is treated with three to nine months of isoniazid alone. This long-term treatment often risks the development of hepatotoxicity. A combination of isoniazid plus rifampicin for a period of three to four months is shown to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iproniazid
Iproniazid (Marsilid, Rivivol, Euphozid, Iprazid, Ipronid, Ipronin) is a non-selective, irreversible inhibition, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine (antidepressant), hydrazine class. It is a xenobiotic that was originally designed to treat tuberculosis, but was later most prominently used as an antidepressant drug. However, it was withdrawn from the market because of its hepatotoxicity. The medical use of iproniazid was discontinued in most of the world in the 1960s, but remained in use in France until its discontinuation in 2015. History Iproniazid was originally developed for the treatment of tuberculosis, but in 1952, its antidepressant properties were discovered when researchers noted that patients became inappropriately happy when given isoniazid, a structural analog of iproniazid. Subsequently, N-isopropyl Addition reaction, addition led to development as an antidepressant and was approved for use in 1958. It was withdrawn in most of the worl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rifampicin
Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), ''Mycobacterium avium'' complex, leprosy, and Legionnaires' disease. It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended" for latent TB infection; and when used as post-exposure prophylaxis to prevent ''Haemophilus influenzae'' type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended. Rifampicin may be given either by mouth or intravenously. Common side effects include nausea, vomiting, diarrhea, and loss of appetite. It often turns urine, sweat, and tears a red or orange color. Liver problems or allergic reactions may occur. It is part of the recommended treatment of active tuberculosis during ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyrazinamide
Pyrazinamide is a medication used to treat tuberculosis. For active tuberculosis, it is often used with rifampicin, isoniazid, and either streptomycin or ethambutol. It is not generally recommended for the treatment of latent tuberculosis. It is taken Oral administration, by mouth. Common side effects include nausea, loss of appetite, muscle and joint pains, and rash. More serious side effects include gout, liver toxicity, and sensitivity to sunlight. It is not recommended in those with significant liver disease or porphyria. It is unclear if use during pregnancy is safe but it is likely okay during breastfeeding. Pyrazinamide is in the antimycobacterial class of medications. How it works is not entirely clear. Pyrazinamide was first made in 1936, but did not come into wide use until 1972. It is on the WHO Model List of Essential Medicines, World Health Organization's List of Essential Medicines. Pyrazinamide is available as a generic medication. Medical uses Pyrazinamide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Walsh McDermott
Walsh McDermott (October 24, 1909 – October 17, 1981) was an American physician, medical researcher and public health specialist. In his early career, he researched antibiotic agents against tuberculosis and syphilis, earning a Lasker Award for his work on isoniazid, a drug used to treat tuberculosis. His later career focused on public health efforts, and he became a professor in public health at Cornell University. Early life McDermott was born on October 24, 1909, in New Haven, Connecticut. He attended Phillips Academy and obtained an undergraduate degree from Princeton University in 1930. He graduated from Columbia University College of Physicians and Surgeons in 1934. Career McDermott completed his internship and residency at New York Hospital, which was then a teaching hospital for Cornell University Medical College. His early career was interrupted by repeated exacerbations of tuberculosis; his health eventually recovered by 1950 after treatment with isoniazid and surgery ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thioacetazone
Thioacetazone (INN, BAN), also known as amithiozone (USAN), is an oral antibiotic which is used in the treatment of tuberculosis. It has fallen into almost complete disuse due to toxicity and the introduction of improved anti-tuberculosis drugs like isoniazid. The drug has only weak activity against ''Mycobacterium tuberculosis'' and is only useful in preventing resistance to more powerful drugs such as isoniazid and rifampicin. It is never used on its own to treat tuberculosis; it is used in a similar way to ethambutol. There is no advantage to using thioacetazone if the regimen used already contains ethambutol, but many countries in sub-Saharan Africa still use thioacetazone because it is extremely cheap. Use of thioacetazone is declining because it can cause severe (sometimes fatal) skin reactions in HIV positive patients. The biological target of thioacetazone has proven elusive and its mechanism of action remains unknown, although it is thought to interfere with mycolic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomycin
Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, Mycobacterium avium complex, ''Mycobacterium avium'' complex, endocarditis, brucellosis, Burkholderia infection, ''Burkholderia'' infection, plague (disease), plague, tularemia, and rat bite fever. For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide. It is administered by intravenous, injection into a vein or intramuscular, muscle. Common side effects include vertigo, vomiting, numbness of the face, fever, and rash. Use during pregnancy may result in permanent deafness in the developing baby. Use appears to be safe while breastfeeding. It is not recommended in people with myasthenia gravis or other neuromuscular disorders. Streptomycin is an aminoglycoside. It works by blocking the ability of 30S ribosomal subunits to make proteins, which results in bactericidal, bacterial death. Albert Schatz (scientist), Albert Schatz f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Many Farms, Arizona
Many Farms () is a census-designated place (CDP) in Apache County, Arizona, United States. The population was 1,348 at the 2010 census. Geography According to the United States Census Bureau, the CDP has a total area of , of which is land and , or 0.3%, is water. Climate According to the Köppen Climate Classification system, Many Farms has a semi-arid climate, abbreviated "BSk" on climate maps. History Many Farms is an English translation of the Navajo name of the area and is descriptive. The farms became fully irrigated in 1937. From 1952 to 1962, the Many Farms community was the location of two major medical experiments led by Walsh McDermott. The goal of the first experiment was to test the efficacy of the drug isoniazid as a treatment for tuberculosis (TB), which was then widespread and largely fatal among the Navajo despite the availability of TB medication elsewhere in the country. McDermott chose the reservation because he needed a population that had not been pre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roche
F. Hoffmann-La Roche AG, commonly known as Roche (), is a Switzerland, Swiss multinational corporation, multinational holding healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has Share (finance), shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the fifth-largest pharmaceutical company in the world by revenue and the leading provider of cancer treatments globally. In 2023, the company’s seat in Forbes Global 2000 was 76. The company owns the American biotechnology company Genentech, which is a wholly owned independent subsidiary, and the Japanese biotechnology company Chugai Pharmaceutical Co., Chugai Pharmaceuticals, as well as the United States–based companies Ventana Medical Systems, Ventana and Foundation Medicine. Roche's revenues during fiscal year 2020, were 58.32 billion Swiss francs. Descendants of the founding Hoffmann and Oeri fam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethambutol
Ethambutol (EMB, E) is a medication primarily used to treat tuberculosis. It is usually given in combination with other tuberculosis medications, such as isoniazid, rifampicin and pyrazinamide. It may also be used to treat ''Mycobacterium avium'' complex, and ''Mycobacterium kansasii''. It is taken by mouth. Common side effects include problems with vision, joint pain, nausea, headaches, and feeling tired. Other side effects include liver problems and allergic reactions. It is not recommended in people with optic neuritis, significant kidney problems, or under the age of five. Use during pregnancy or breastfeeding has not been found to cause harm. In the United States the FDA has raised concerns about eye issues in the baby if used during pregnancy. Ethambutol is believed to work by interfering with the bacteria's metabolism. Ethambutol was discovered in 1961. It is on the World Health Organization's List of Essential Medicines and is available as a generic medication. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerhard Domagk
Gerhard Johannes Paul Domagk (; 30 October 1895 – 24 April 1964) was a German pathologist and bacteriologist. He is credited with the discovery of Sulfonamide (medicine), sulfonamidochrysoidine (KL730) as an antibiotic for which he received the 1939 Nobel Prize in Physiology or Medicine. The drug became the first commercially available antibiotic and marketed under the brand name Prontosil. While working in the pathology department of the University of Münster, Domagk was invited to join the IG Farben branch at Elberfeld (later Wuppertal) in 1927. His duty was to test chemical compounds prepared at the IG Farben laboratory for potential drugs. A novel compound synthesised by Friedrich Mietzsch and Joseph Klarer, a benzene derivative of azo dye attached with sulphonamide group as a side chain was found to have antibacterial activity against human bacterium ''Streptococcus pyogenes.'' In 1935, Domagk's only daughter, Hildegarde, injured herself and contracted a streptococcal in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Navajo Nation
The Navajo Nation (), also known as Navajoland, is an Indian reservation of Navajo people in the United States. It occupies portions of northeastern Arizona, northwestern New Mexico, and southeastern Utah. The seat of government is located in Window Rock, Arizona. At roughly , the Navajo Nation is the largest Indian reservation in the United States, exceeding the size of List of U.S. states and territories by area, ten U.S. states. It is one of the few reservations whose lands overlap the nation's traditional homelands. In 2010, the reservation was home to 173,667 out of 332,129 Navajo tribal members; the remaining 158,462 tribal members lived outside the reservation, in urban areas (26%), border towns (10%), and elsewhere in the U.S. (17%). In 2020, the number of tribal members increased to 399,494, surpassing the Cherokee Nation as the largest tribal group by enrollment. The U.S. Mexican Cession, gained ownership of what is today Navajoland in 1848 following the Mexican–A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
