Indolizidine Alkaloids

	Indolizidine Alkaloids Indolizidine alkaloids are natural products from various alkaloid groups whose structure can be derived from indolizidine. Occurrence Indolizidine alkaloids are present in various plant families, including Elaeocarpaceae, Asclepiadaceae, and are also produced as metabolites by fungi and bacteria. For instance, Slaframine and swainsonine were identified in the fungus '' Rhizoctonia leguminicola'', while Castanospermine was extracted from Castanospermum australe. Notably, this alkaloid group includes pumiliotoxins, which are the toxins of the ''strawberry poison-dart frog''. Representatives Polyhydroxy alkaloids The polyhydroxy alkaloids include compounds like castanospermine and swainsonine. (+)-Castanospermine Structural Formula V1.svg, (+)-Castanospermine (-)-Swainsonine Structural Formula V2.svg, (-)-Swainsonine Pumiliotoxins The primary alkaloids within the pumiliotoxin category are pumiliotoxin A and pumiliotoxin B. Other representatives include gephyrotoxin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Indolizine Structural Formula V2-Seite001 Indolizine is an heterocyclic compound with the formula C8H7N). It is an uncommon isomer of indole with the nitrogen located at a ring fusion position. The Saturated and unsaturated compounds, saturated structural analog, analog is indolizidine, which is the core of a variety of alkaloids such as swainsonine. Examples of some simple fully synthetic substituted indolizines include 2ZEDMA, 1ZP2MA, and 1Z2MAP1O. References External links Chemical synthesis of indolizines Indolizines, {{heterocyclic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
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	Norsecurinine Norsecurinine is a securinega alkaloid from '' Phyllanthus niruri''. See also * Securinine Securinine is an alkaloid found in '' Securinega suffruticosa'' and '' Phyllanthus niruri''. Pharmacology Securinine has pro-convulsant effects and it has a strong spastic effect, similar to the actions of strychnine. Securinine is a GABA-A ... References {{Reflist Indolizidine alkaloids Heterocyclic compounds with 4 rings Nitrogen heterocycles Lactones Cyclohexenes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Securinine Securinine is an alkaloid found in '' Securinega suffruticosa'' and '' Phyllanthus niruri''. Pharmacology Securinine has pro-convulsant effects and it has a strong spastic effect, similar to the actions of strychnine. Securinine is a GABA-A antagonist. See also * Norsecurinine * Phenazine Phenazine is an organic compound with the formula (C6H4)2N2. It is a dibenzo annulation, annulated pyrazine, and the parent substance of many dyestuffs, such as the toluylene red, indulines, and safranines (and the closely related eurhodines). Phe ... References {{Reflist Tetracyclic compounds Nitrogen heterocycles Lactones Indolizidine alkaloids Furanones Heterocyclic compounds with 4 rings Withdrawn drugs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]