Securinine is an
alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...
found in ''
Securinega suffruticosa
''Flueggea suffruticosa'' is a species of flowering plant in the family Phyllanthaceae. It is a deciduous shrub that is widely distributed in Asia, America, Europe, and Africa. It is one of the Chinese herbology#50 fundamental herbs, 50 fundament ...
''
and ''
Phyllanthus niruri
''Phyllanthus niruri'' is a widespread tropical plant commonly found in coastal areas, known by the common names gale of the wind, stonebreaker, shatter stone , seed-under-leaf, quebra pedra and chance pierre. It is in the genus ''Phyllanthus'' ...
''.
Pharmacology
Securinine has pro-convulsant effects and it has a strong
spastic effect, similar to the actions of
strychnine
Strychnine (, , US chiefly ) is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the eye ...
.
Securinine is a GABA-
A antagonist.
See also
*
Norsecurinine
*
Phenazine
Phenazine is an organic compound with the formula (C6H4)2N2. It is a dibenzo annulation, annulated pyrazine, and the parent substance of many dyestuffs, such as the toluylene red, indulines, and safranines (and the closely related eurhodines). Phe ...
References
{{Reflist
Tetracyclic compounds
Nitrogen heterocycles
Lactones
Alkaloids
Furanones
Cyclohexenes
Withdrawn drugs