Imidafenacin
Imidafenacin (INN) is a urinary antispasmodic of the anticholinergic class. Pharmacol: Synthesis *The sidechain is a versatile precursor also used in the synthesis of: Bezitramide, Piritramide, Diphenoxylate, & others. The alkylation of Diphenylacetonitrile 6-29-3(1) with 1,2-dibromoethane 1,2-Dibromoethane, also known as ethylene dibromide (EDB), is an organobromine compound with the chemical formula . Although trace amounts occur naturally in the ocean, where it is formed probably by algae and kelp, it is mainly synthetic. It is ... (2) gives 4-Bromo-2,2-Diphenylbutyronitrile 9186-58-8(3). Alkylation with 2-Methylimidazole (4) gives 4-(2-Methyl-1H-imidazol-1-yl)-2,2-diphenylbutanenitrile 14777-43-2(5). Partial hydrolysis of the nitrile to the amide completes the synthesis of ' (6). References Muscarinic antagonists Imidazoles Carboxamides {{genito-urinary-drug-stub ...
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Imidafenacin Synthesis
Imidafenacin ( INN) is a urinary antispasmodic of the anticholinergic class. Pharmacol: Synthesis *The sidechain is a versatile precursor also used in the synthesis of: Bezitramide, Piritramide, Diphenoxylate, & others. The alkylation of Diphenylacetonitrile 6-29-3(1) with 1,2-dibromoethane (2) gives 4-Bromo-2,2-Diphenylbutyronitrile 9186-58-8(3). Alkylation with 2-Methylimidazole 2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH3C3H2N2H. It is a white or colorless solid that is highly soluble in polar organic solvents and water. It is a precursor to a range of d ... (4) gives 4-(2-Methyl-1H-imidazol-1-yl)-2,2-diphenylbutanenitrile 14777-43-2(5). Partial hydrolysis of the nitrile to the amide completes the syn