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Imidafenacin ( INN) is a urinary antispasmodic of the anticholinergic class.
Pharmacol:
The alkylation of Diphenylacetonitrile 6-29-3(1) with
Synthesis
*The sidechain is a versatile precursor also used in the synthesis of: Bezitramide,Piritramide
Piritramide(R-3365, trade names Dipidolor, Piridolan, Pirium and others) is a synthetic opioid analgesic (narcotic painkiller) that is marketed in certain European countries including: Austria, Belgium, Czech Republic, Slovenia, Germany and the ...
, Diphenoxylate, & others.
The alkylation of Diphenylacetonitrile 6-29-3(1) with 1,2-dibromoethane
1,2-Dibromoethane, also known as ethylene dibromide (EDB), is an organobromine compound with the chemical formula . Although trace amounts occur naturally in the ocean, where it is formed probably by algae and kelp, it is mainly synthetic. It is a ...
(2) gives 4-Bromo-2,2-Diphenylbutyronitrile 9186-58-8(3). Alkylation with 2-Methylimidazole
2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH3C3H2N2H. It is a white or colorless solid that is highly soluble in polar organic solvents and water. It is a precursor to a range of d ...
(4) gives 4-(2-Methyl-1H-imidazol-1-yl)-2,2-diphenylbutanenitrile 14777-43-2(5). Partial hydrolysis of the nitrile to the amide completes the synthesis of ' (6).
References
Muscarinic antagonists Imidazoles Carboxamides {{genito-urinary-drug-stub