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Ibogalog
Noribogaminalog, or ''N''-desmethylibogaminalog, also known as 1,2,3,4,5,6-hexahydroazepino[4,5-b]indole, is a chemical compound and parent structure of the ibogalog group of compounds. The ibogalogs that have been described include ibogaminalog, ibogainalog, noribogainalog, tabernanthalog, fluorogainalog, LS-22925, PNU-22394, and PHA-57378, among others. The ibogalogs, specifically ibogainalog and analogues, were first described in the scientific literature by 1968. See also * Azepinoindole * Iboga-type alkaloid * Desethylibogamine References External links Noribogaminalog - Isomer DesignIbogalogs, Drug Discovery, and the New Psychedelic Era - NeuWrite West Ibogalogs {{Organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ibogaminalog
Ibogaminalog (developmental code name DM-506) is a drug of the ibogalog group first invented in the 1960s, which acts as both a partial agonist at the 5-HT2A receptor, 5-HT2A Receptor (biochemistry), receptor, and a negative allosteric modulator at the α7 and α9α10 nicotinic acetylcholine receptors. It can be regarded as a structurally simplified derivative of ibogaine and has been researched both for anti-addictive effects and for the treatment of neuropathic pain. See also * Ibogalog * Lorcaserin * PHA-57378 * PNU-22394 * PNU-181731 * Ibogainalog * Tabernanthalog References N,N-Dialkyltryptamines Ibogalogs Serotonin receptor agonists {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ibogainalog
Ibogainalog (IBG), also known as 9-methoxyibogaminalog, is a serotonergic psychedelic and psychoplastogen of the ibogalog group related to ibogaine but with a simplified chemical structure. Pharmacology It acts as a serotonin 5-HT2A receptor agonist, serotonin 5-HT2B receptor antagonist, and also interacts with other serotonin receptors, such as the serotonin 5-HT1F receptor (agonist), 5-HT2C receptor (very weak partial agonist or antagonist), and 5-HT6 receptor (agonist). Unlike noribogaine, IBG shows no activation of the opioid receptors or κ-opioid receptor agonism. In addition to its actions at serotonin receptors, IBG inhibits certain nicotinic acetylcholine receptors. The drug produces the head-twitch response in animals and hence shows psychedelic-like effects. However, it has reduced hallucinogen-like effects compared to 5-MeO-DMT. Conversely, tabernanthalog (TBG), a simplified analogue of tabernanthine and positional isomer of IBG, appears to be completely non-h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tabernanthalog
Tabernanthalog (TBG, DLX-007) is a novel water-soluble, non-toxic ibogalog or simplified analogue of the psychoactive drug tabernanthine first synthesized by David E. Olson at UC Davis. Tabernanthalog is a non-hallucinogenic serotonin 5-HT2A receptor agonist. It is also a serotonin 5-HT2B receptor antagonist. The drug is described as having high selectivity for the serotonin 5-HT2 receptors. Other targets of the drug include monoamine oxidase A (MAO-A), the α2A-adrenergic receptor, the serotonin 5-HT1B and 5-HT2C receptors, and the serotonin transporter (SERT). In rodents, it was found to promote structural neural plasticity, reduce drug seeking behavior, and produce antidepressant like effects. It has also been shown that it effectively reduces motivation for heroin and alcohol in rats. This indicates its efficacy in animals with a history of heroin and alcohol polydrug use. Due to the rapidly-induced and enduring neuroplasticity, tabernanthalog is a member of the clas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PNU-22394
PNU-22394 is a drug of the ibogalog group which acts as an agonist at serotonin 5-HT2 Receptor (biochemistry), receptors, with strongest binding affinity for 5-HT2A receptor, 5-HT2A and 5-HT2C receptor, 5-HT2C and slightly weaker at 5-HT2B receptor, 5-HT2B, although it is only a full agonist at 5-HT2C, but partial agonist at 5-HT2A and 5-HT2B. It has anorectic effects in both animal studies and human trials, along with "Pro-Cognitive Properties", although it has never been developed for medical use. See also * Ibogalog * Ibogaminalog * Lorcaserin * Tryptoline * PNU-181731 * PHA-57378 * Tabernanthalog References 1-Alkyltryptamines Ibogalogs N-Monoalkyltryptamines Serotonin receptor agonists {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PHA-57378
PHA-57378 is a drug related to the ibogalogs which acts as an agonist at serotonin 5-HT2 receptors, having a binding affinity of 4.1 nM at the 5-HT2A subtype and 4.3 nM at 5-HT2C. It has anxiolytic effects in animal studies. See also * Ibogalog * PNU-22394 PNU-22394 is a drug of the ibogalog group which acts as an agonist at serotonin 5-HT2 Receptor (biochemistry), receptors, with strongest binding affinity for 5-HT2A receptor, 5-HT2A and 5-HT2C receptor, 5-HT2C and slightly weaker at 5-HT2B recept ... * PNU-181731 * WAY-470 References 1-Alkyltryptamines Ibogalogs N-Monoalkyltryptamines Serotonin receptor agonists {{anxiolytic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azepinoindole
Azepinoindole is a tricyclic chemical compound related to tryptamine and having various alkaloid derivatives. The analogue of azepinoindole with the azepine ring fully hydrogenated, 1,2,3,4,5,6-hexahydroazepino 4,5-b/nowiki>indole">/nowiki>4,5-b/nowiki>indole, is a parent compound of the iboga-type alkaloids such as ibogaine, ibogamine, and tabernanthine as well as their simplified ibogalog analogues ibogainalog, ibogaminalog, and tabernanthalog. See also * Desethylibogamine * Substituted β-carboline * PHA-57378 * PNU-22394 * PNU-181731 * Tryptoline Tryptoline, also known as tetrahydro-β-carboline and tetrahydronorharmane, is a natural organic derivative of β-carboline. It is an alkaloid chemically related to tryptamines. Derivatives of tryptoline have a variety of pharmacological propert ... References {{Chemical classes of psychoactive drugs Tricyclic compounds * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Desethylibogamine
Desethylibogamine, or 4-desethylibogamine, also known as noribogamine, is a chemical compound and parent structure of the iboga-type alkaloids such as ibogaine and ibogamine. It is the 4-desethyl analogue of ibogamine and features the ibogaine ring system with no other substitutions. The total synthesis of desethylibogamine was described in the mid-1960s. See also * Iboga-type alkaloid * Noribogaminalog * Azepinoindole Azepinoindole is a tricyclic chemical compound related to tryptamine and having various alkaloid derivatives. The analogue of azepinoindole with the azepine ring fully hydrogenated, 1,2,3,4,5,6-hexahydroazepino 4,5-b/nowiki>indole">/nowiki>4,5- ... (ibogalog) References External links Desethylibogamine - Isomer Design Azepinoindoles Heterocyclic compounds with 5 rings {{Organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element is therefore not a compound. A compound can be transformed into a different substance by a chemical reaction, which may involve interactions with other substances. In this process, bonds between atoms may be broken or new bonds formed or both. There are four major types of compounds, distinguished by how the constituent atoms are bonded together. Molecular compounds are held together by covalent bonds; ionic compounds are held together by ionic bonds; intermetallic compounds are held together by metallic bonds; coordination complexes are held together by coordinate covalent bonds. Non-stoichiometric compounds form a disputed marginal case. A chemical formula specifies the number of atoms of each element in a compound molecule, usin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parent Structure
In chemistry, a parent structure is the structure of an unadorned ion or molecule from which derivatives can be visualized. Parent structures underpin systematic nomenclature and facilitate classification. Fundamental parent structures have one or no functional groups and often have various types of symmetry. Benzene () is a chemical itself consisting of a hexagonal ring of carbon atoms with a hydrogen atom attached to each, and is the parent of many derivatives that have substituent atoms or groups replacing one or more of the hydrogens. Some parents are rare or nonexistent themselves, as in the case of porphine, though many simple and complex derivatives are known. File:Benzene circle.png, Benzene is the parent. File:Toluene-vec.svg, Toluene is a derivative of benzene. File:Porphyrin.svg, Porphine is the parent of porphyrins. File:PPIXtransH.png, Protoporphyrin IX is a natural derivative of the parent porphine. File:H2octaethylporphyrin.png, Octaethylporphyrin is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |