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Hypsibius Exemplaris
''Hypsibius dujardini sensu lato'' is a species complex of tardigrade in the class Eutardigrada. A member of this complex, ''Hypsibius exemplaris'', is widely used for various research projects pertaining to evolutionary biology and astrobiology. The species was described by Louis Michel François Doyère in 1840 (as ''Macrobiotus dujardini''). ''H. exemplaris'' was differentiated from ''H. dujardini sensu stricto'' in 2018. Earlier studies refer to this lab species from northwest England as ''H. dujardini''. ''H. dujardini s.s.'' is found in France, and has differences in 18S rRNA sequence and morphological details. Habitat The species, ''Hypsibius dujardini'', is a tardigrade that prefers freshwater lakes, rivers, and streams. Because they are considered cosmopolitan, their geographical range is immense. They can be found in regions like the tropics and the poles. Genome sequencing The genome of ''Hypsibius exemplaris'' has been sequenced. ''Hypsibius exemplaris'' has a com ...
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Louis Michel François Doyère
Louis Michel François Doyère (born 28 January 1811 in Saint-Michel-des-Essartiers, Calvados; died 12 July 1863 in Bastia, Corsica) was a French zoologist and agronomist. He was among the first zoologists to study tardigrades, describing species including ''Milnesium tardigradum'' in 1840. Life After obtaining his degree in science, Doyère became a professor in Paris. In 1838, he translated into French the 1836 book ''Geology and Mineralogy considered with reference to Natural Theology'' by William Buckland. Two years later, he published with Dezobry and Magdeleine, a work entitled: ''Lessons in Natural History''. From 1841 to 1842, he was a preparatory assistant at the laboratory of anatomy and natural history of Man, at the French National Museum of Natural History. In 1842, he defended his thesis at the Faculty of Sciences of Paris on the biology of tardigrades, including their ability to survive complete desiccation. In the historian of science Hartmut Greven's words ...
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Species Complex
In biology, a species complex is a group of closely related organisms that are so similar in appearance and other features that the boundaries between them are often unclear. The taxa in the complex may be able to hybridize readily with each other, further blurring any distinctions. Terms that are sometimes used synonymously but have more precise meanings are cryptic species for two or more species hidden under one species name, sibling species for two (or more) species that are each other's closest relative, and species flock for a group of closely related species that live in the same habitat. As informal taxonomic ranks, species group, species aggregate, macrospecies, and superspecies are also in use. Two or more taxa that were once considered conspecific (of the same species) may later be subdivided into infraspecific taxa (taxa within a species, such as plant variety (botany), varieties), which may be a complex ranking but it is not a species complex. In most cases, a specie ...
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Tardigrade
Tardigrades (), known colloquially as water bears or moss piglets, are a phylum of eight-legged segmented micro-animals. They were first described by the German zoologist Johann August Ephraim Goeze in 1773, who called them . In 1776, the Italian biologist Lazzaro Spallanzani named them Tardigrada, which means 'slow walkers'. They live in diverse regions of Earth's biospheremountaintops, the deep sea, tropical rainforests, and the Antarctic. Tardigrades are among the most resilient animals known, with individual species able to survive extreme conditions – such as exposure to extreme temperatures, extreme pressures (both high and low), air deprivation, radiation, dehydration, and starvation – that would quickly kill most other forms of life. Tardigrades have survived exposure to outer space. There are about 1,500 known species in the phylum Tardigrada, a part of the superphylum Ecdysozoa. The earliest known fossil is from the Cambrian, some 500 million years ago ...
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Eutardigrada
Eutardigrada are a class of tardigrades (Tardigrada) without lateral appendages. Primarily freshwater bound, some species have secondarily gained the ability to live in marine environments ('' Halobiotus''). By cryptobiosis many species are able to live temporarily in very dry environments. More than 700 species have been described. The order Apochela consists of only one family, Milnesiidae, with two genera: '' Milnesium'' and '' Limmenius''. ''Milnesium tardigradum'' can be found worldwide and is one of the biggest species among tardigrades (up to 1.4 mm); similar-looking species have been found in Cretaceous amber. The mouth of this predator has a wide opening, so the animal can eat rotifers and larger protist A protist ( ) or protoctist is any eukaryotic organism that is not an animal, land plant, or fungus. Protists do not form a natural group, or clade, but are a paraphyletic grouping of all descendants of the last eukaryotic common ancest ...s. Other eu ...
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Evolutionary Biology
Evolutionary biology is the subfield of biology that studies the evolutionary processes such as natural selection, common descent, and speciation that produced the diversity of life on Earth. In the 1930s, the discipline of evolutionary biology emerged through what Julian Huxley called the Modern synthesis (20th century), modern synthesis of understanding, from previously unrelated fields of biological research, such as genetics and ecology, systematics, and paleontology. The investigational range of current research has widened to encompass the genetic architecture of adaptation, molecular evolution, and the different forces that contribute to evolution, such as sexual selection, genetic drift, and biogeography. The newer field of evolutionary developmental biology ("evo-devo") investigates how embryogenesis is controlled, thus yielding a wider synthesis that integrates developmental biology with the fields of study covered by the earlier evolutionary synthesis. Subfields ...
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Astrobiology
Astrobiology (also xenology or exobiology) is a scientific field within the List of life sciences, life and environmental sciences that studies the abiogenesis, origins, Protocell, early evolution, distribution, and future of life in the universe by investigating its deterministic conditions and contingent events. As a discipline, astrobiology is founded on the premise that life may exist beyond Earth. Research in astrobiology comprises three main areas: the study of planetary habitability, habitable environments in the Solar System and beyond, the search for planetary biosignatures of past or present extraterrestrial life, and the study of the Abiogenesis, origin and Protocell, early evolution of life on Earth. The field of astrobiology has its origins in the 20th century with the advent of space exploration and the discovery of exoplanets. Early astrobiology research focused on the search for extraterrestrial life and the study of the potential for life to exist on other pl ...
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Sensu Stricto
''Sensu'' is a Latin word meaning "in the sense of". It is used in a number of fields including biology, geology, linguistics, semiotics, and law. Commonly it refers to how strictly or loosely an expression is used in describing any particular concept, but it also appears in expressions that indicate the convention or context of the usage. Common qualifiers ''Sensu'' is the ablative case of the noun ''sensus'', here meaning "sense". It is often accompanied by an adjective (in the same case). Three such phrases are: * – "in the strict sense", abbreviation ''s.s.'' or ''s.str.''; * – "in the broad sense", abbreviation ''s.l.''; * – "in a relaxed, generous (or 'ample') sense", a similar meaning to ''sensu lato''. Søren Kierkegaard uses the phrase ''sensu eminenti'' to mean "in the pre-eminent r most important or significantsense". When appropriate, comparative and superlative adjectives may also be used to convey the meaning of "more" or "most". Thus ''sensu strict ...
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Proceedings Of The National Academy Of Sciences Of The United States Of America
''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Sciences, published since 1915, and publishes original research, scientific reviews, commentaries, and letters. According to ''Journal Citation Reports'', the journal has a 2022 impact factor of 9.4. ''PNAS'' is the second most cited scientific journal, with more than 1.9 million cumulative citations from 2008 to 2018. In the past, ''PNAS'' has been described variously as "prestigious", "sedate", "renowned" and "high impact". ''PNAS'' is a delayed open-access journal, with an embargo period of six months that can be bypassed for an author fee ( hybrid open access). Since September 2017, open access articles are published under a Creative Commons license. Since January 2019, ''PNAS'' has been online-only, although print issues are available ...
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Developmental Biology (journal)
''Developmental Biology'' is a peer-reviewed scientific journal. It was established in 1959 and is the official journal of the Society for Developmental Biology. It publishes research on the mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, and genetic levels. The journal is published twice a month by Elsevier. Abstracting and indexing The journal is abstracted an indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor of 3.582. Looking at Scimago Journal & Country Rank data trends, citations A citation is a reference to a source. More precisely, a citation is an abbreviated alphanumeric expression embedded in the body of an intellectual work that denotes an entry in the bibliographic references section of the work for the purpose o ... per document declined substantially between 1999 and 2020, while the number of uncited documents increased over the same period. The number of c ...
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Dsup
Dsup (contraction of ''damage suppressor'') is a DNA-associating protein, unique to the tardigrade, that suppresses the occurrence of DNA breaks by radiation. When human HEK293 cells were engineered with Dsup proteins, they showed approximately 40% more tolerance against X-ray radiation. Tardigrades can withstand 1,000 times more radiation than other animals, median lethal doses of 5,000 Gy (of gamma rays) and 6,200 Gy (of heavy ions) in hydrated animals (5 to 10 Gy could be fatal to a human). The only explanation found in earlier experiments for this ability was that their lowered water state provides fewer reactants for ionizing radiation. However, subsequent research found that tardigrades, when hydrated, still remain highly resistant to shortwave UV radiation in comparison to other animals, and that one factor for this is their ability to efficiently repair damage to their DNA resulting from that exposure. A landmark study on Dsup protein showed that it can bind nucleosomes ...
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Nucleosome
A nucleosome is the basic structural unit of DNA packaging in eukaryotes. The structure of a nucleosome consists of a segment of DNA wound around eight histone, histone proteins and resembles thread wrapped around a bobbin, spool. The nucleosome is the fundamental subunit of chromatin. Each nucleosome is composed of a little less than two turns of DNA wrapped around a set of eight proteins called histones, which are known as a histone octamer. Each histone octamer is composed of two copies each of the histone proteins Histone H2A, H2A, Histone H2B, H2B, Histone H3, H3, and Histone H4, H4. DNA must be compacted into nucleosomes to fit within the cell nucleus. In addition to nucleosome wrapping, eukaryotic chromatin is further compacted by being folded into a series of more complex structures, eventually forming a chromosome. Each human cell contains about 30 million nucleosomes. Nucleosomes are thought to carry Epigenetics, epigenetically inherited information in the form of coval ...
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Chromatin
Chromatin is a complex of DNA and protein found in eukaryote, eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in reinforcing the DNA during cell division, preventing DNA repair#DNA damage, DNA damage, and regulating gene expression and DNA replication. During mitosis and meiosis, chromatin facilitates proper segregation of the chromosomes in anaphase; the characteristic shapes of chromosomes visible during this stage are the result of DNA being coiled into highly condensed chromatin. The primary protein components of chromatin are histones. An octamer of two sets of four histone cores (Histone H2A, Histone H2B, Histone H3, and Histone H4) bind to DNA and function as "anchors" around which the strands are wound.Maeshima, K., Ide, S., & Babokhov, M. (2019). Dynamic chromatin organization without the 30 nm fiber. ''Current opinion in cell biolog ...
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