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HIV-2
The subtypes of HIV include two main subtypes, known as HIV type 1 (HIV-1) and HIV type 2 (HIV-2). These subtypes have distinct genetic differences and are associated with different epidemiological patterns and clinical characteristics. HIV-1 exhibits a genetic relation to viruses indigenous to chimpanzees and gorillas that inhabit West Africa, while HIV-2 viruses are affiliated with viruses present in the sooty mangabey, a vulnerable West African primate. HIV-1 viruses can be further stratified into groups M, N, O, and P. Among these, HIV-1 group M viruses are the most prevalent, infecting nearly 90% of people living with HIV and are responsible for the global AIDS pandemic. Group M can be further subdivided into subtypes based on genetic sequence data. Certain subtypes are known for their increased virulence or drug resistance to different medications used to treat HIV. HIV-2 viruses are generally considered to be less virulent and less transmissible than HIV-1 M group vir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Immunodeficiency Virus 1
The subtypes of HIV include two main subtypes, known as HIV type 1 (HIV-1) and HIV type 2 (HIV-2). These subtypes have distinct genetic differences and are associated with different Epidemiology, epidemiological patterns and clinical characteristics. HIV-1 exhibits a genetic relation to viruses indigenous to chimpanzees and gorillas that inhabit West Africa, while HIV-2 viruses are affiliated with viruses present in the sooty mangabey, a Vulnerable species, vulnerable West African primate. HIV-1 viruses can be further stratified into groups M, N, O, and P. Among these, HIV-1 group M viruses are the most prevalent, infecting nearly 90% of people living with HIV and are responsible for the global AIDS pandemic. Group M can be further subdivided into subtypes based on genetic sequence data. Certain subtypes are known for their increased virulence or drug resistance to different medications used to treat HIV. HIV-2 viruses are generally considered to be less virulent and less Pathoge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Immunodeficiency Virus 2
The subtypes of HIV include two main subtypes, known as HIV type 1 (HIV-1) and HIV type 2 (HIV-2). These subtypes have distinct genetic differences and are associated with different epidemiological patterns and clinical characteristics. HIV-1 exhibits a genetic relation to viruses indigenous to chimpanzees and gorillas that inhabit West Africa, while HIV-2 viruses are affiliated with viruses present in the sooty mangabey, a vulnerable West African primate. HIV-1 viruses can be further stratified into groups M, N, O, and P. Among these, HIV-1 group M viruses are the most prevalent, infecting nearly 90% of people living with HIV and are responsible for the global AIDS pandemic. Group M can be further subdivided into subtypes based on genetic sequence data. Certain subtypes are known for their increased virulence or drug resistance to different medications used to treat HIV. HIV-2 viruses are generally considered to be less virulent and less transmissible than HIV-1 M group vi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Simian Immunodeficiency Virus
Simian immunodeficiency virus (SIV) is a species of retrovirus that cause persistent infections in at least 45 species of non-human primates. Based on analysis of strains found in four species of monkeys from Bioko Island, which was isolated from the mainland by rising sea levels about 11,000 years ago, it has been concluded that SIV has been present in monkeys and apes for at least 32,000 years, and probably much longer. Virus strains from three of these primate species, SIVsmm in sooty mangabeys, SIVgor in gorillas and SIVcpz in chimpanzees, are believed to have crossed the species barrier into humans, resulting in HIV-2 and HIV-1 respectively, the two HIV viruses. The most likely route of transmission of HIV-1 to humans involves contact with the blood of chimps and gorillas that are often hunted for bushmeat in Africa. Four subtypes of HIV-1 (M, N, O, and P) likely arose through four separate transmissions of SIV to humans, and the resulting HIV-1 group M strain most ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sooty Mangabey
The sooty mangabey (''Cercocebus atys'') is an Old World monkey found in forests from Senegal in a margin along the coast down to the Ivory Coast. Habitat and ecology The sooty mangabey is native to tropical West Africa, being found in Guinea, Guinea-Bissau, Liberia, Senegal, Sierra Leone, and Ivory Coast. Sooty mangabeys inhabit both old growth and secondary forests as well as in flooded, dry, swamp, mangrove, and gallery forests. Sooty mangabeys are terrestrial omnivores, typically spending around 75% of their overall time on the ground (~85% of travel time and ~71% of foraging time). In their foraging behaviors, sooty mangabeys typically consume fruits (~20% of diet), invertebrates (~13% of diet), and nuts and seeds (>55% of diet). In acquiring nuts, sooty mangabeys have been observed scavenging the remains of coula and panda nuts cracked by chimpanzees and red river hogs, potentially using either the sound of cracking nuts or social networks to identify sites of remnants. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Management Of HIV/AIDS
The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy (HAART). HAART decreases the patient's total burden of HIV, maintains function of the immune system, and prevents opportunistic infections that often lead to death. HAART also prevents the transmission of HIV between serodiscordant same-sex and opposite-sex partners so long as the HIV-positive partner maintains an undetectable viral load. Treatment has been so successful that in many parts of the world, HIV has become a chronic condition in which progression to AIDS is increasingly rare. Anthony Fauci, former head of the United States National Institute of Allergy and Infectious Diseases, has written, "With collective and resolute action n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Belgian Congo
The Belgian Congo (, ; ) was a Belgian colonial empire, Belgian colony in Central Africa from 1908 until independence in 1960 and became the Republic of the Congo (Léopoldville). The former colony adopted its present name, the Democratic Republic of the Congo (DRC), in 1964. Colonization of the Congo Basin, Colonial rule in the Congo began in the late 19th century. Leopold II of the Belgians, King Leopold II of the Belgians attempted to persuade the Federal Government of Belgium, Belgian government to support colonial expansion around the then-largely unexploited Congo Basin. Their ambivalence resulted in Leopold establishing a colony himself. With support from a number of Berlin Conference, Western countries, Leopold achieved international recognition of the Congo Free State in 1885. By the turn of the century, the violence used by Free State officials against indigenous Congolese and a ruthless system of economic exploitation led to intense diplomatic pressure on Belgium to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reading Frames
In molecular biology, a reading frame is a specific choice out of the possible ways to read the sequence of nucleotides in a nucleic acid (DNA or RNA) molecule as a sequence of triplets. Where these triplets equate to amino acids or stop signals during translation, they are called codons. A single strand of a nucleic acid molecule has a phosphoryl end, called the 5′-end, and a hydroxyl or 3′-end. These define the 5′→3′ direction. There are three reading frames that can be read in this 5′→3′ direction, each beginning from a different nucleotide in a triplet. In a double stranded nucleic acid, an additional three reading frames may be read from the other, complementary strand in the 5′→3′ direction along this strand. As the two strands of a double-stranded nucleic acid molecule are antiparallel, the 5′→3′ direction on the second strand corresponds to the 3′→5′ direction along the first strand. In general, at the most, one reading frame in a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Léopoldville
Kinshasa (; ; ), formerly named Léopoldville from 1881–1966 (), is the capital and largest city of the Democratic Republic of the Congo. Kinshasa is one of the world's fastest-growing megacities, with an estimated population of 17 million in 2024. It is the most densely populated city in the DRC, the most populous city and third-largest metropolitan area in Africa, and the world's twenty-second most populous city and fourth-most populous capital city. It is the leading economic, political, and cultural center of the DRC, housing several industries including manufacturing, telecommunications, banking, and entertainment. The city also hosts some of DRC's significant institutional buildings, such as the People's Palace, Palace of the Nation, Court of Cassation, Constitutional Court, African Union City, Marble Palace, Martyrs Stadium, Government House, Kinshasa Financial Center, and other national departments and agencies. The Kinshasa site has been inhabited by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clade
In biology, a clade (), also known as a Monophyly, monophyletic group or natural group, is a group of organisms that is composed of a common ancestor and all of its descendants. Clades are the fundamental unit of cladistics, a modern approach to taxonomy adopted by most biological fields. The common ancestor may be an individual, a population, or a species (extinct or Extant taxon, extant). Clades are nested, one in another, as each branch in turn splits into smaller branches. These splits reflect evolutionary history as populations diverged and evolved independently. Clades are termed ''monophyletic'' (Greek: "one clan") groups. Over the last few decades, the cladistic approach has revolutionized biological classification and revealed surprising evolutionary relationships among organisms. Increasingly, taxonomists try to avoid naming Taxon, taxa that are not clades; that is, taxa that are not Monophyly, monophyletic. Some of the relationships between organisms that the molecul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
