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Geoffrey Harris (neuroendocrinologist)
Geoffrey Wingfield Harris (1913–1971) was a British physiologist and neuroendocrinology, neuroendocrinologist. Often considered the "father of neuroendocrinology",Raisman, G. (1997)"An urge to explain the incomprehensible: Geoffrey Harris and the discovery of the neural control of the pituitary gland." ''Annual Reviews of Neuroscience'', 20:533-56doi:10.1146/annurev.neuro.20.1.533/ref> he is best known for showing that the anterior pituitary is regulated by the hypothalamus via the hypophyseal portal system. His work established the principles for the 1977 Nobel Prize-winning discovery of hypothalamic hormones by Andrew Schally, Schally and Roger Guillemin, Guillemin. Education and career Harris received his undergraduate degree from University of Cambridge, Cambridge in 1936, and went on to attend medical training at St. Mary's Hospital in London until 1939.Sawin, C. T. (1998Geoffrey Harris and the Brain's Control of the Pituitary Gland. ''The Endocrinologist'', 8(2):117-122. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the European mainland, continental mainland. It comprises England, Scotland, Wales and Northern Ireland. The United Kingdom includes the island of Great Britain, the north-eastern part of the island of Ireland, and many List of islands of the United Kingdom, smaller islands within the British Isles. Northern Ireland shares Republic of Ireland–United Kingdom border, a land border with the Republic of Ireland; otherwise, the United Kingdom is surrounded by the Atlantic Ocean, the North Sea, the English Channel, the Celtic Sea and the Irish Sea. The total area of the United Kingdom is , with an estimated 2020 population of more than 67 million people. The United Kingdom has evolved from a series of annexations, unions and separations of constituent countries over several hundred years. The Treaty of Union between ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of London
The University of London (UoL; abbreviated as Lond or more rarely Londin in post-nominals) is a federal public research university located in London, England, United Kingdom. The university was established by royal charter in 1836 as a degree-awarding examination board for students holding certificates from University College London and King's College London and "other such other Institutions, corporate or unincorporated, as shall be established for the purpose of Education, whether within the Metropolis or elsewhere within our United Kingdom". This fact allows it to be one of three institutions to claim the title of the third-oldest university in England, and moved to a federal structure in 1900. It is now incorporated by its fourth (1863) royal charter and governed by the University of London Act 2018. It was the first university in the United Kingdom to introduce examinations for women in 1869 and, a decade later, the first to admit women to degrees. In 1913, it appoi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1971 Deaths
* The year 1971 had three partial solar eclipses (February 25, July 22 and August 20) and two total lunar eclipses (February 10, and August 6). The world population increased by 2.1% this year, the highest increase in history. Events January * January 2 – 66 people are killed and over 200 injured during a crush in Glasgow, Scotland. * January 5 – The first ever One Day International cricket match is played between Australia and England at the Melbourne Cricket Ground. * January 8 – Tupamaros kidnap Geoffrey Jackson, British ambassador to Uruguay, in Montevideo, keeping him captive until September. * January 9 – Uruguayan president Jorge Pacheco Areco demands emergency powers for 90 days due to kidnappings, and receives them the next day. * January 12 – The landmark United States television sitcom ''All in the Family'', starring Carroll O'Connor as Archie Bunker, debuts on CBS. * January 14 – Seventy Brazilian political prisoners are release ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1913 Births
Events January * January 5 – First Balkan War: Battle of Lemnos (1913), Battle of Lemnos – Greek admiral Pavlos Kountouriotis forces the Turkish fleet to retreat to its base within the Dardanelles, from which it will not venture for the rest of the war. * January 13 – Edward Carson founds the (first) Ulster Volunteers, Ulster Volunteer Force, by unifying several existing Ulster loyalism, loyalist militias to resist home rule for Ireland. * January 23 – 1913 Ottoman coup d'état: Ismail Enver comes to power. * January – Stalin (whose first article using this name is published this month) travels to Vienna to carry out research. Until he leaves on February 16 the city is home simultaneously to him, Hitler, Trotsky and Josip Broz Tito, Tito alongside Alban Berg, Berg, Freud and Jung and Ludwig Wittgenstein, Ludwig and Paul Wittgenstein. February * February 1 – New York City's Grand Central Terminal, having been rebuilt, reopens as the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gonadotropin-releasing Hormone
Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis. Structure The identity of GnRH was clarified by the 1977 Nobel Laureates Roger Guillemin and Andrew V. Schally: pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 As is standard for peptide representation, the sequence is given from amino terminus to carboxyl terminus; also standard is omission of the designation of chirality, with assumption that all amino acids are in their L- form. The abbreviations are the standard abbreviations for the corresponding proteinogenic amino acids, except for ''pyroGlu'', which refers to pyroglutamic acid, a derivative ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Physiology Or Medicine
The Nobel Prize in Physiology or Medicine ( sv, Nobelpriset i fysiologi eller medicin) is awarded yearly by the Nobel Assembly at the Karolinska Institute, Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Nobel Prize in Physics, Physics, Medicine or Physiology, Nobel Prize in Chemistry, Chemistry, Nobel Prize in Literature, Literature, and Nobel Peace Prize, Peace. The Nobel Prize is presented annually on the anniversary of Alfred Nobel's death, 10 December. As of 2023, 115 Nobel Prizes in Physiology or Medicine have been awarded to 227 laureates, 214 men and 13 women. The first one was awarded in 1901 to the German physiologist, Emil von Behring, for his work on blood plasma, s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroids
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signaling molecules. Hundreds of steroids are found in plants, animals and fungi. All steroids are manufactured in cells from the sterols lanosterol ( opisthokonts) or cycloartenol (plants). Lanosterol and cycloartenol are derived from the cyclization of the triterpene squalene. The steroid core structure is typically composed of seventeen carbon atoms, bonded in four " fused" rings: three six-member cyclohexane rings (rings A, B and C in the first illustration) and one five-member cyclopentane ring (the D ring). Steroids vary by the functional groups attached to this four-ring core and by the oxidation state of the rings. Sterols are forms of steroids with a hydroxy group at position three and a skeleton derived from cholest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medial Eminence Of Floor Of Fourth Ventricle
In the human brain, the rhomboid fossa is divided into symmetrical halves by a median sulcus which reaches from the upper to the lower angles of the fossa and is deeper below than above. On either side of this sulcus is an elevation, the medial eminence, bounded laterally by a sulcus, the sulcus limitans. In the superior part of the fossa the medial eminence has a width equal to that of the corresponding half of the fossa, but opposite the superior fovea it forms an elongated swelling, the ''colliculus facialis'', which overlies the nucleus of the abducent nerve, and is, in part at least, produced by the internal genu of the facial nerve The facial nerve, also known as the seventh cranial nerve, cranial nerve VII, or simply CN VII, is a cranial nerve that emerges from the pons of the brainstem, controls the muscles of facial expression, and functions in the conveyance of ta .... References External links * https://web.archive.org/web/20081224022115/http://isc.temple.e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dora Jacobsohn
Dora Elisabeth Jacobsohn (1908–1983) was a German-Swedish physiologist and endocrinologist. Considered one of the early pioneers of the field of neuroendocrinology, she is best known for her work with Geoffrey Harris showing that the anterior pituitary gland is controlled by the hypothalamus via the hypophyseal portal system. Biography Jacobsohn was born in Berlin in 1908. She earned her M.D. in Germany in 1933, but she was not allowed to practice medicine in Germany because she was Jewish. Fleeing Nazi Germany, Jacobsohn moved to Sweden in 1934, where she had family. There, she met Axel Westman at the Uppsala University Hospital, who permitted her to observe and assist in his endocrinological research on ovulation and reproduction in hypophysectomized (pituitary removed) animals. Although Jacobsohn was not permitted to do research as she was a foreigner without a Swedish degree, she worked with Westman at Lund University and ran clinical hormone assays for the hospital. N ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Oxford
The University of Oxford is a collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the world's second-oldest university in continuous operation. It grew rapidly from 1167 when Henry II banned English students from attending the University of Paris. After disputes between students and Oxford townsfolk in 1209, some academics fled north-east to Cambridge where they established what became the University of Cambridge. The two English ancient universities share many common features and are jointly referred to as ''Oxbridge''. Both are ranked among the most prestigious universities in the world. The university is made up of thirty-nine semi-autonomous constituent colleges, five permanent private halls, and a range of academic departments which are organised into four divisions. All the colleges are self-governing institutions within the university, each controlling ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by King Charles II as The Royal Society and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the Society's President, according to a set of statutes and standing orders. The members of Council and the President are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS ( Fellow of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Posterior Pituitary
The posterior pituitary (or neurohypophysis) is the posterior lobe of the pituitary gland which is part of the endocrine system. The posterior pituitary is not glandular as is the anterior pituitary. Instead, it is largely a collection of axonal projections from the hypothalamus that terminate behind the anterior pituitary, and serve as a site for the secretion of neurohypophysial hormones ( oxytocin and vasopressin) directly into the blood. The hypothalamic–neurohypophyseal system is composed of the hypothalamus (the paraventricular nucleus and supraoptic nucleus), posterior pituitary, and these axonal projections. Structure The posterior pituitary consists mainly of neuronal projections (axons) of magnocellular neurosecretory cells extending from the supraoptic and paraventricular nuclei of the hypothalamus. These axons store and release neurohypophysial hormones oxytocin and vasopressin into the neurohypophyseal capillaries, from there they get into the systemic ci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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