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Galegine
Galegine is a toxic chemical compound that has been isolated from '' Galega officinalis''. It has also been found to be the principal cause of the toxicity of poison sedge (''Schoenus asperocarpus''). Galegine was used in the 1920s as a pharmaceutical treatment for diabetes; however, because of its toxicity, its use was soon supplanted by superior alternatives. Research on galegine eventually led to the development of metformin which is used today for treatment of type 2 diabetes Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent .... See also * Nitensidine D References {{reflist Guanidine alkaloids Plant toxins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Galega Officinalis
''Galega officinalis'', commonly known as galega or goat's-rue, is a herbaceous plant in the subfamily Faboideae of the legume Family (biology), family Fabaceae. It is native species, native to parts of northern Africa, western Asia and Europe, but is widely cultivated and naturalised elsewhere. The plant has been extensively cultivated as a forage crop, an ornamental, a bee plant, and as green manure. ''G. officinalis'' is rich in galegine, a substance with blood glucose-lowering activity and the foundation for the discovery of metformin, a treatment for managing symptoms of diabetes, diabetes mellitus. In ancient herbalism, goat's-rue was used as a diuretic. It can be poisonous to mammals, but is a food for various insects. Etymology The English name "goat's-rue" is a translation of the Latin ''Ruta capraria'', used for the plant in 1554 when it was considered to be related to ''Ruta graveolens'', or common rue. The Latin binomial nomenclature, specific epithet ''officinalis'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metformin
Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome, and is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in people who take antipsychotic medication. It has been shown to inhibit inflammation, and is not associated with weight gain. Metformin is taken by mouth. Metformin is generally well tolerated. Common adverse effects include diarrhea, nausea, and abdominal pain. It has a small risk of causing low blood sugar. High blood lactic acid level (acidosis) is a concern if the medication is used in overly large doses or prescribed in people with severe kidney problems. Metformin is a biguanide anti- hyperglycemic agent. It works by decreasing glucose production in the liver, increasing the insulin sensitivity of body tissues, and increasing GDF15 s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element is therefore not a compound. A compound can be transformed into a different substance by a chemical reaction, which may involve interactions with other substances. In this process, bonds between atoms may be broken or new bonds formed or both. There are four major types of compounds, distinguished by how the constituent atoms are bonded together. Molecular compounds are held together by covalent bonds; ionic compounds are held together by ionic bonds; intermetallic compounds are held together by metallic bonds; coordination complexes are held together by coordinate covalent bonds. Non-stoichiometric compounds form a disputed marginal case. A chemical formula specifies the number of atoms of each element in a compound molecule, usin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Type 2 Diabetes
Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urination, fatigue and unexplained weight loss. Other symptoms include increased hunger, having a sensation of pins and needles, and sores (wounds) that heal slowly. Symptoms often develop slowly. Long-term complications from high blood sugar include heart disease, stroke, diabetic retinopathy, which can result in blindness, kidney failure, and poor blood flow in the lower limbs, which may lead to amputations. A sudden onset of hyperosmolar hyperglycemic state may occur; however, ketoacidosis is uncommon. Type 2 diabetes primarily occurs as a result of obesity and lack of exercise. Some people are genetically more at risk than others. Type 2 diabetes makes up about 90% of cases of diabetes, with the other 10% due primar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nitensidine D
Nitensidine D is a toxic alkaloid natural product that was isolated from the leaves of the South American legume '' Pterogyne nitens''. It is also hypothesized to be a possible intermediate in the still unknown, seemingly monoterpene based, terrestrial biosynthetic pathway for tetrodotoxin. See also * Galegine Galegine is a toxic chemical compound that has been isolated from '' Galega officinalis''. It has also been found to be the principal cause of the toxicity of poison sedge (''Schoenus asperocarpus''). Galegine was used in the 1920s as a pharmace ... References Guanidine alkaloids Plant toxins {{alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guanidine Alkaloids
Guanidine is the compound with the formula HNC(NH2)2. It is a colourless solid that dissolves in polar solvents. It is a strong base that is used in the production of plastics and explosives. It is found in urine predominantly in patients experiencing renal failure. A guanidine moiety also appears in larger organic molecules, including on the side chain of arginine. Structure Guanidine can be thought of as a nitrogenous analogue of carbonic acid. That is, the C=O group in carbonic acid is replaced by a C=NH group, and each OH is replaced by a group. A detailed crystallographic analysis of guanidine was elucidated 148 years after its first synthesis, despite the simplicity of the molecule. In 2013, the positions of the hydrogen atoms and their displacement parameters were accurately determined using single-crystal neutron diffraction. Production Guanidine can be obtained from natural sources, being first isolated in 1861 by Adolph Strecker via the oxidative degradation of an ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
