''Galega officinalis'', commonly known as galega or goat's-rue, is a herbaceous plant in the

subfamily In biological classification, a subfamily (Latin: ', plural ') is an auxiliary (intermediate) taxonomic rank, next below family but more inclusive than genus. Standard nomenclature rules end botanical subfamily names with "-oideae", and zo ...

Faboideae The Faboideae are a subfamily of the flowering plant family Fabaceae or Leguminosae. An acceptable alternative name for the subfamily is Papilionoideae, or Papilionaceae when this group of plants is treated as a family. This subfamily is widely ...

of the legume

family Family (from ) is a Social group, group of people related either by consanguinity (by recognized birth) or Affinity (law), affinity (by marriage or other relationship). It forms the basis for social order. Ideally, families offer predictabili ...

Fabaceae Fabaceae () or Leguminosae,International Code of Nomen ...

. It is

native Native may refer to: People * '' Jus sanguinis'', nationality by blood * '' Jus soli'', nationality by location of birth * Indigenous peoples, peoples with a set of specific rights based on their historical ties to a particular territory ** Nat ...

to parts of northern Africa, western Asia and Europe, but is widely cultivated and naturalised elsewhere. The plant has been extensively cultivated as a forage crop, an ornamental, a bee plant, and as

green manure In agriculture, a green manure is a crop specifically cultivated to be incorporated into the soil while still green. Typically, the green manure's Biomass (ecology), biomass is incorporated with a plow or disk, as is often done with (brown) man ...

. ''G. officinalis'' is rich in

galegine Galegine is a toxic chemical compound that has been isolated from '' Galega officinalis''. It has also been found to be the principal cause of the toxicity of poison sedge (''Schoenus asperocarpus''). Galegine was used in the 1920s as a pharmace ...

, a substance with

blood glucose The blood sugar level, blood sugar concentration, blood glucose level, or glycemia is the measure of glucose concentrated in the blood. The body tightly blood sugar regulation, regulates blood glucose levels as a part of metabolic homeostasis ...

-lowering activity and the foundation for the discovery of

metformin Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome, ...

, a treatment for managing symptoms of

diabetes mellitus Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained hyperglycemia, high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or th ...

. In ancient

herbalism Herbal medicine (also called herbalism, phytomedicine or phytotherapy) is the study of pharmacognosy and the use of medicinal plants, which are a basis of traditional medicine. Scientific evidence for the effectiveness of many herbal treatments ...

, goat's-rue was used as a

diuretic A diuretic () is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. A diuretic tablet is sometimes colloquially called a water tablet. There are several categories of diuretics. All diuretics ...

. It can be poisonous to mammals, but is a food for various insects.

Etymology

The English name "goat's-rue" is a translation of the Latin ''Ruta capraria'', used for the plant in 1554 when it was considered to be related to ''

Ruta graveolens ''Ruta graveolens'', commonly known as rue, common rue or herb-of-grace, is a species of the genus ''Ruta'' grown as an ornamental plant and herb. It is native to the Mediterranean. It is grown throughout the world in gardens, especially for it ...

'', or common rue. The Latin

specific epithet In Taxonomy (biology), taxonomy, binomial nomenclature ("two-term naming system"), also called binary nomenclature, is a formal system of naming species of living things by giving each a name composed of two parts, both of which use Latin gramm ...

''officinalis'' refers to plants with some medicinal, culinary or herbal attributes. ''Galega bicolor'' is a synonym.

Distribution and habitat

Widely distributed throughout

temperate In geography, the temperate climates of Earth occur in the middle latitudes (approximately 23.5° to 66.5° N/S of the Equator), which span between the tropics and the polar regions of Earth. These zones generally have wider temperature ran ...

regions of the world, predominantly in Europe, the plant is a hardy

perennial In horticulture, the term perennial ('' per-'' + '' -ennial'', "through the year") is used to differentiate a plant from shorter-lived annuals and biennials. It has thus been defined as a plant that lives more than 2 years. The term is also ...

that blooms in the summer months on

grassland A grassland is an area where the vegetation is dominance (ecology), dominated by grasses (Poaceae). However, sedge (Cyperaceae) and rush (Juncaceae) can also be found along with variable proportions of legumes such as clover, and other Herbaceo ...

wetland A wetland is a distinct semi-aquatic ecosystem whose groundcovers are flooded or saturated in water, either permanently, for years or decades, or only seasonally. Flooding results in oxygen-poor ( anoxic) processes taking place, especially ...

s, and riverbanks, and is classified as an

invasive weed An invasive species is an introduced species that harms its new environment. Invasive species adversely affect habitats and bioregions, causing ecological, environmental, and/or economic damage. The term can also be used for native species ...

in many parts of North America. It has also been found in

South America South America is a continent entirely in the Western Hemisphere and mostly in the Southern Hemisphere, with a considerably smaller portion in the Northern Hemisphere. It can also be described as the southern Subregion#Americas, subregion o ...

North Africa North Africa (sometimes Northern Africa) is a region encompassing the northern portion of the African continent. There is no singularly accepted scope for the region. However, it is sometimes defined as stretching from the Atlantic shores of t ...

Pakistan Pakistan, officially the Islamic Republic of Pakistan, is a country in South Asia. It is the List of countries and dependencies by population, fifth-most populous country, with a population of over 241.5 million, having the Islam by country# ...

Turkey Turkey, officially the Republic of Türkiye, is a country mainly located in Anatolia in West Asia, with a relatively small part called East Thrace in Southeast Europe. It borders the Black Sea to the north; Georgia (country), Georgia, Armen ...

, and

New Zealand New Zealand () is an island country in the southwestern Pacific Ocean. It consists of two main landmasses—the North Island () and the South Island ()—and List of islands of New Zealand, over 600 smaller islands. It is the List of isla ...

. In 1891 in the United States, ''Galega officinalis'' was introduced experimentally at

Utah State University Utah State University (USU or Utah State) is a public university, public land grant colleges, land-grant research university with its main campus in Logan, Utah, United States. Founded in 1888 under the Morrill Land-Grant Acts as Utah's federal ...

for potential use as a

forage Forage is a plant material (mainly plant leaves and stems) eaten by grazing livestock. Historically, the term ''forage'' has meant only plants eaten by the animals directly as pasture, crop residue, or immature cereal crops, but it is also used m ...

crop, but

escaped cultivation An escaped plant is a cultivated plant that has escaped from agriculture, forestry or garden cultivation and has become naturalized in the wild. Usually not native to an area, escaped plants may become invasive. Therefore, escaped plants are th ...

and is now an agricultural pest. As a result, it has been placed on the

Federal Noxious Weed List The Federal Noxious Weed Act of 1974 ("FNWA", ) established a federal program to control the spread of noxious weeds. The United States Secretary of Agriculture was given the authority to declare plants "noxious weeds", and limit the interstate s ...

in the

United States The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...

. It was collected in

Colorado Colorado is a U.S. state, state in the Western United States. It is one of the Mountain states, sharing the Four Corners region with Arizona, New Mexico, and Utah. It is also bordered by Wyoming to the north, Nebraska to the northeast, Kansas ...

Connecticut Connecticut ( ) is a U.S. state, state in the New England region of the Northeastern United States. It borders Rhode Island to the east, Massachusetts to the north, New York (state), New York to the west, and Long Island Sound to the south. ...

and

New York New York most commonly refers to: * New York (state), a state in the northeastern United States * New York City, the most populous city in the United States, located in the state of New York New York may also refer to: Places United Kingdom * ...

prior to the 1930s, and in

Maine Maine ( ) is a U.S. state, state in the New England region of the United States, and the northeasternmost state in the Contiguous United States. It borders New Hampshire to the west, the Gulf of Maine to the southeast, and the Provinces and ...

and

Pennsylvania Pennsylvania, officially the Commonwealth of Pennsylvania, is a U.S. state, state spanning the Mid-Atlantic (United States), Mid-Atlantic, Northeastern United States, Northeastern, Appalachian, and Great Lakes region, Great Lakes regions o ...

in the 1960s, but the populations appear to have died out.

Chemistry and herbalism

Although not thoroughly studied with 21st century methods, ''G. officinalis'' has been analyzed for its constituents, which include

, hydroxygalegine, several

guanidine Guanidine is the compound with the formula HNC(NH2)2. It is a colourless solid that dissolves in polar solvents. It is a strong base that is used in the production of plastics and explosives. It is found in urine predominantly in patients experi ...

derivatives, such as 4-hydroxygalegine

flavone Flavone is an organic compound with the formula . A white solid, flavone is a derivative of chromone with a phenyl (Ph) substituent adjacent to the ether group. The compound is of little direct practical importance, but substituted derivatives, ...

s, flavone

glycoside In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. ...

kaempferol Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods including kale, beans, tea, spinach, and broccoli. It is also found in propolis extracts. Kaempferol i ...

, and

quercetin Quercetin is a plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds, and grains; capers, red onions, and kale are common foods containing appreciable amounts of it. It has a bitter flavor ...

. In addition to its purported effect to lower

levels and induce diuresis, goat's rue was used as a

herbal tonic In herbal medicine, a herbal tonic (also tonic herbs, tonic herbalism) is used to help restore, tone and invigorate systems in the Human body, body or to promote general health and Wellness (alternative medicine), well-being. A herbal tonic is a ...

in folk medicine practices of

medieval Europe In the history of Europe, the Middle Ages or medieval period lasted approximately from the 5th to the late 15th centuries, similarly to the post-classical period of World history (field), global history. It began with the fall of the West ...

to treat

bubonic plague Bubonic plague is one of three types of Plague (disease), plague caused by the Bacteria, bacterium ''Yersinia pestis''. One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and ...

worm Worms are many different distantly related bilateria, bilateral animals that typically have a long cylindrical tube-like body, no limb (anatomy), limbs, and usually no eyes. Worms vary in size from microscopic to over in length for marine ...

s, and

snake bite A snakebite is an injury caused by the bite of a snake, especially a venomous snake. A common sign of a bite from a venomous snake is the presence of two puncture wounds from the animal's fangs. Sometimes venom injection from the bite may ...

Relation to metformin

Once used in

traditional medicine Traditional medicine (also known as indigenous medicine or folk medicine) refers to the knowledge, skills, and practices rooted in the cultural beliefs of various societies, especially Indigenous groups, used for maintaining health and treatin ...

over centuries, ''G. officinalis'' is at the foundation of the

biguanide Biguanide () is the organic compound with the formula HN(C(NH)NH2)2. It is a colorless solid that dissolves in water to give a highly basic solution. These solutions slowly hydrolyse to ammonia and urea. Synthesis Biguanide can be obtained fro ...

class of

antidiabetic drug Drugs used in diabetes treat types of diabetes mellitus by decreasing blood sugar level, glucose levels in the blood. With the exception of Insulin (medication), insulin, most GLP-1 receptor agonists (liraglutide, exenatide, and others), and pra ...

s, which also included

phenformin Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases. Phenformin was devel ...

and

buformin Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed by German pharmaceutical company Grünenthal as Silubin. Chemistry and animal toxicology Bufor ...

(both discontinued). ''G. officinalis'' contains the

phytochemical Phytochemicals are naturally-occurring chemicals present in or extracted from plants. Some phytochemicals are nutrients for the plant, while others are metabolites produced to enhance plant survivability and reproduction. The fields of ext ...

s, galegine and guanidine, both of which decrease

blood sugar The blood sugar level, blood sugar concentration, blood glucose level, or glycemia is the measure of glucose concentrated in the blood. The body tightly regulates blood glucose levels as a part of metabolic homeostasis. For a 70 kg (1 ...

, but were discovered to cause

adverse effect An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery. An adverse effect may be termed a "side effect", when judged to be secondary to a main or therapeutic effect. The term compli ...

s in human studies. The study of galegine and related molecules in the first half of the 20th century led to development of oral antidiabetic drugs. Research on other compounds related to guanidine, including biguanide, led ultimately to the discovery of

(

trade name A trade name, trading name, or business name is a pseudonym used by companies that do not operate under their registered company name. The term for this type of alternative name is fictitious business name. Registering the fictitious name with ...

, Glucophage), used in the 21st century for management of diabetes by decreasing liver glucose production and increasing

insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabol ...

sensitivity of body tissues.

Adverse effects

Goat's rue may interfere with prescribed diabetes drugs,

iron Iron is a chemical element; it has symbol Fe () and atomic number 26. It is a metal that belongs to the first transition series and group 8 of the periodic table. It is, by mass, the most common element on Earth, forming much of Earth's o ...

absorption, and

anticoagulant An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which ...

s. It may cause

headache A headache, also known as cephalalgia, is the symptom of pain in the face, head, or neck. It can occur as a migraine, tension-type headache, or cluster headache. There is an increased risk of Depression (mood), depression in those with severe ...

or muscular weakness, and its safety during pregnancy or breastfeeding is unknown.

Gallery

File:Galega officinalis1UME.jpg, ''Galega officinalis'', a natural source of galegine File:Illustration Galega officinalis1.jpg, ''Galega officinalis'' - from Thomé, ''Flora von Deutschland, Österreich und der Schweiz'' 1885 File:Galega officinalis 1997 Detail.jpg, ''Galega officinalis'' - Hortus Eystettensis, Eichstätt File:Galega officinalis sl33.jpg, Top side of leaf File:Galega officinalis sl37.jpg, Bottom side of leaf

References

External links

Taxonomy
on NCBI (National Library of Medicine). {{Galactagogues Galactagogues Galegeae Flora of Pakistan Medicinal plants of Africa Medicinal plants of Asia Plants described in 1753 Taxa named by Carl Linnaeus