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GRAMD1B
GRAM domain containing 1B, also known as GRAMD1B, Aster-B and KIAA1201, is a cholesterol transport protein that is encoded by the ''GRAMD1B'' gene. It contains a Transmembrane protein, transmembrane region and two Protein domain, domains of known function; the GRAM domain and a VAD1 analog of StAR-related lipid transfer, VASt domain. It is anchored to the endoplasmic reticulum. This highly conserved gene is found in a variety of vertebrates and invertebrates. Sequence_homology, Homologs (Lam/Ltc proteins) are found in yeast. Gene GRAMD1B, also known as KIAA1201, is located in the human genome at 11q24.1. It is located on the + strand and is flanked by a variety of other genes. It spans 269,347 bases. mRNA The most verified Protein isoform, isoform, isoform 1, contains 21 exons. There are four validated isoform variants of human GRAMD1B. These consist of truncated 5’ and 3’ regions, resulting in the loss of an exon. One prominent analysis of the mouse gene predicts on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GRAMD1B Gene Region
GRAM domain containing 1B, also known as GRAMD1B, Aster-B and KIAA1201, is a cholesterol transport protein that is encoded by the ''GRAMD1B'' gene. It contains a transmembrane region and two domains of known function; the GRAM domain and a VASt domain. It is anchored to the endoplasmic reticulum. This highly conserved gene is found in a variety of vertebrates and invertebrates. Homologs (Lam/Ltc proteins) are found in yeast. Gene GRAMD1B, also known as KIAA1201, is located in the human genome at 11q24.1. It is located on the + strand and is flanked by a variety of other genes. It spans 269,347 bases. mRNA The most verified isoform, isoform 1, contains 21 exons. There are four validated isoform variants of human GRAMD1B. These consist of truncated 5’ and 3’ regions, resulting in the loss of an exon. One prominent analysis of the mouse gene predicts one form of Gramd1b that is 699 amino acids long. Protein GRAMD1B is an integral membrane protein that contains sev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GRAM Domain
The GRAM domain is found in glucosyltransferases, myotubularins and other membrane-associated proteins. The structure of the GRAM domain is similar to that found in PH domains. Proteins containing GRAM domains are found in all eukaryotes and bacteria, but not archaea. Various GRAM domains can bind proteins or lipids. Human proteins containing this domain GRAMD1A; GRAMD1B; GRAMD1C; GRAMD2A; GRAMD2B; GRAMD4; MTM1; MTMR1; MTMR2; NCOA7; NSMAF; OXR1; SBF1; SBF2 Myotubularin-related protein 13 is a protein that in humans is encoded by the ''SBF2'' gene. The family of myotubularin-related proteins includes lipid phosphatases, such as MTM1 (MIM 600415), and pseudophosphatases, such as SBF1 (MIM 603560) an ...; TBC1D8; TBC1D8B; TBC1D9; TBC1D9B; WBP2; WBP2NL; dJ439F8.1; References Protein domains Protein families Peripheral membrane proteins {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
VAD1 Analog Of StAR-related Lipid Transfer
VAD1 analog of StAR-related lipid transfer (VASt) is a steroidogenic acute regulatory protein‐related lipid transfer (StART)-like lipid-binding domain first identified in the vad1 (vascular associated death1) protein in ''Arabidopsis thaliana'' (mouse-ear cress ). Proteins containing these domains are found in eukaryotes and usually contain another lipid-binding domain, typically the GRAM domain and sometimes the C2 domain in plants and the integral peroxisomal membrane peroxin Pex24p domain in oomycetes. Structure The VASt domain structurally resembles a truncated form of a START domain, but with limited sequence similarity. While VASt is a member of the Bet v1-like superfamily, it is unclear if it evolved from the same ancestral domain as the START domain or is an example of convergent evolution. The domain is highly conserved across all eukaryotes and is typically present in only one copy in VASt domain-containing proteins. Like the START domain, the VASt domain consist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ortholog
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene transfer event (xenologs). Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity. Significant similarity is strong evidence that two sequences are related by evolutionary changes from a common ancestral sequence. Alignments of multiple sequences are used to indicate which regions of each sequence are homologous. Identity, similarity, and conservation The term "percent homology" is often used to mean "sequence similarity”, that is the percentage of identical residues (''percent identity''), or the percentage of residues conserved with similar physicochemical properties (''p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tissue Expression Of GRAMD1B
Tissue may refer to: Biology * Tissue (biology), an ensemble of similar (or dissimilar in structure but same in origin) cells that together carry out a specific function * ''Triphosa haesitata'', a species of geometer moth ("tissue moth") found in North America * ''Triphosa dubitata'', a species of geometer moth ("tissue") found in Afro-Eurasia Paper products * Tissue paper, a type of thin, gauzy translucent paper used for wrapping and cushioning items * Tissue (cloth), a thin, transparent, and lightweight fabric * Facial tissue, tissue paper used for cleaning the face * Japanese tissue, tissue paper from Japan made of vegetable fibers * Toilet paper, tissue paper used for cleaning the anus * Wrapping tissue, tissue paper used for wrapping and cushioning items Other * Aerial tissue, an acrobatic art form and one of the circus arts * "The Tissue (Tomaranai Seishun) is the third single by the Japanese girl idol group Shiritsu Ebisu Chugaku (or fourth counting one cover single), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leucine Zipper
A leucine zipper (or leucine scissors) is a common three-dimensional structural motif in proteins. They were first described by Landschulz and collaborators in 1988 when they found that an enhancer binding protein had a very characteristic 30-amino acid segment and the display of these amino acid sequences on an idealized alpha helix revealed a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. The polypeptide segments containing these periodic arrays of leucine residues were proposed to exist in an alpha-helical conformation and the leucine side chains from one alpha helix interdigitate with those from the alpha helix of a second polypeptide, facilitating dimerization. Leucine zippers are a dimerization motif of the BZIP domain, bZIP (Basic-region leucine zipper) class of eukaryotic transcription factors. The bZIP domain is 60 to 80 amino acids in length with a highly conserved DNA binding basic region and a more divers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Predicted 3D Structure Of GRAMD1B
A prediction (Latin ''præ-'', "before," and ''dictum'', "something said") or forecast is a statement about a future event or about future data. Predictions are often, but not always, based upon experience or knowledge of forecasters. There is no universal agreement about the exact difference between "prediction" and "estimation"; different authors and disciplines ascribe different connotations. Future events are necessarily uncertain, so guaranteed accurate information about the future is impossible. Prediction can be useful to assist in making plans about possible developments. Opinion In a non-statistical sense, the term "prediction" is often used to refer to an informed guess or opinion. A prediction of this kind might be informed by a predicting person's abductive reasoning, inductive reasoning, deductive reasoning, and experience; and may be useful—if the predicting person is a knowledgeable person in the field. The Delphi method is a technique for eliciting suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mammal
A mammal () is a vertebrate animal of the Class (biology), class Mammalia (). Mammals are characterised by the presence of milk-producing mammary glands for feeding their young, a broad neocortex region of the brain, fur or hair, and three Evolution of mammalian auditory ossicles, middle ear bones. These characteristics distinguish them from reptiles and birds, from which their ancestors Genetic divergence, diverged in the Carboniferous Period over 300 million years ago. Around 6,640 Neontology#Extant taxon, extant species of mammals have been described and divided into 27 Order (biology), orders. The study of mammals is called mammalogy. The largest orders of mammals, by number of species, are the rodents, bats, and eulipotyphlans (including hedgehogs, Mole (animal), moles and shrews). The next three are the primates (including humans, monkeys and lemurs), the Artiodactyl, even-toed ungulates (including pigs, camels, and whales), and the Carnivora (including Felidae, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Predicted Alpha-helix Structure Of GRAMD1B Transmembrane Region
A prediction (Latin ''præ-'', "before," and ''dictum'', "something said") or forecast is a statement about a future event or about future data. Predictions are often, but not always, based upon experience or knowledge of forecasters. There is no universal agreement about the exact difference between "prediction" and "estimation"; different authors and disciplines ascribe different connotations. Future events are necessarily uncertain, so guaranteed accurate information about the future is impossible. Prediction can be useful to assist in making plans about possible developments. Opinion In a non-statistical sense, the term "prediction" is often used to refer to an informed guess or opinion. A prediction of this kind might be informed by a predicting person's abductive reasoning, inductive reasoning, deductive reasoning, and experience; and may be useful—if the predicting person is a knowledgeable person in the field. The Delphi method is a technique for eliciting suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
