The GRAM domain is found in

glucosyltransferase Glucosyltransferases are a type of glycosyltransferase that enable the transfer of glucose. Examples include: * glycogen synthase * glycogen phosphorylase Glycogen phosphorylase is one of the phosphorylase enzymes (). Glycogen phosphorylase ca ...

myotubularin Myotubularin domain represents a region within eukaryotic myotubularin-related proteins that is sometimes found with the GRAM domain . Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and p ...

s and other membrane-associated proteins. The structure of the GRAM domain is similar to that found in PH domains. Proteins containing GRAM domains are found in all

eukaryotes Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bact ...

and

bacteria Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were am ...

, but not archaea. Various GRAM domains can bind proteins or lipids.

Human proteins containing this domain

GRAMD1A; GRAMD1B; GRAMD1C; GRAMD2A; GRAMD2B; GRAMD4;

MTM1 Myotubularin is a protein that in humans is encoded by the ''MTM1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' o ...

;

MTMR1 Myotubularin-related protein 1 is a protein that in humans is encoded by the ''MTMR1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generatio ...

;

MTMR2 Myotubularin-related protein 2 also known as phosphatidylinositol-3,5-bisphosphate 3-phosphatase or phosphatidylinositol-3-phosphate phosphatase is a protein that in humans is encoded by the MTMR2 gene. Function This gene is a member of the myo ...

; NCOA7; NSMAF; OXR1;

SBF1 Myotubularin-related protein 5 is a protein that in humans is encoded by the ''SBF1'' gene. Interactions SBF1 has been shown to interact with MTMR2 and SUV39H1 Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encode ...

;

SBF2 Myotubularin-related protein 13 is a protein that in humans is encoded by the ''SBF2'' gene. The family of myotubularin-related proteins includes lipid phosphatases, such as MTM1 (MIM 600415), and pseudophosphatases, such as SBF1 (MIM 603560) and ...

; TBC1D8; TBC1D8B;

TBC1D9 TBC1 domain family member 9 is a protein that in humans is encoded by the ''TBC1D9'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation' ...

; TBC1D9B; WBP2; WBP2NL; dJ439F8.1;

References

Protein domains Protein families Peripheral membrane proteins {{membrane-protein-stub