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Fuculose
Fuculose or 6-deoxy-tagatose is a ketohexose deoxy sugar Deoxy sugars are sugars that have had a hydroxyl group replaced with a hydrogen atom. Examples include: * Deoxyribose, or 2-deoxy-D-ribose, a constituent of DNA * Fucose, or 6-deoxy-L-galactose, main component of fucoidan of brown algae, and pr .... Fuculose is involved in the process of sugar metabolism. -Fuculose can be formed from -fucose by -fucose isomerase and converted to L-fuculose-1-phosphate by -fuculose kinase. See also * -fuculose-phosphate aldolase * -fuculosekinase References Deoxy sugars Ketohexoses Furanoses {{biochem-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
L-fuculose-phosphate Aldolase
The enzyme L-fuculose-phosphate aldolase () catalyzes the chemical reaction : L-fuculose-1-phosphate \rightleftharpoons glycerone phosphateGlycerone phosphate is often known as dihydroxyacetone phosphate. + (''S'')-lactaldehyde This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-fuculose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming). Other names in common use include L-fuculose 1-phosphate aldolase, fuculose aldolase, and L-fuculose-1-phosphate lactaldehyde-lyase. This enzyme participates in fructose and mannose metabolism. Structural studies As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , , and . See also * Fuculose Fuculose or 6-deoxy-tagatose is a ketohexose deoxy sugar Deoxy sugars are sugars that have had a hydroxyl group replaced with a hydrogen atom. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ketohexose
In chemistry, a hexose is a monosaccharide (simple sugar) with six carbon atoms. The chemical formula for all hexoses is , and their molecular weight is 180.156 g/mol. Hexoses exist in two forms, open-chain or cyclic, that easily convert into each other in aqueous solutions. The open-chain form of a hexose, which usually is favored in solutions, has the general structure , where ''n'' is 1, 2, 3, 4, 5. Namely, five of the carbons have one hydroxyl functional group () each, connected by a single bond, and one has an oxo group (), forming a carbonyl group (). The remaining bonds of the carbon atoms are satisfied by seven hydrogen atoms. The carbons are commonly numbered 1 to 6 starting at the end closest to the carbonyl. Hexoses are extremely important in biochemistry, both as isolated molecules (such as glucose and fructose) and as building blocks of other compounds such as starch, cellulose, and glycosides. Hexoses can form dihexose (like sucrose) by a condensation reactio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deoxy Sugar
Deoxy sugars are sugars that have had a hydroxyl group replaced with a hydrogen atom. Examples include: * Deoxyribose, or 2-deoxy-D-ribose, a constituent of DNA * Fucose, or 6-deoxy-L-galactose, main component of fucoidan of brown algae, and present in N-linked glycans * Fuculose, or 6-deoxy-L- tagatose, one of the important components of avian influenza virus particles * Rhamnose, or 6-deoxy-L-mannose, present in plant glycosides In ''Escherichia coli'' bacteria, deoxyribose sugars are synthesized via two different pathways - one pathway involves aldol condensation, whereas the other pathway is conversion of a ribose sugar into a deoxyribose sugar by means of changes on the nucleotide or nucleoside level. Deoxyribose is synthesized through the reduction of ribose. Deoxyribose is derived from the same precursor as ribose being that the reduction of the sugar with the extra hydroxyl group results in the deoxy-sugar, which has its hydroxyl group replaced with a hydrogen atom. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fucose
Fucose is a hexose deoxy sugar with the chemical formula C6H12O5. It is found on ''N''-linked glycans on the mammalian, insect and plant cell surface. Fucose is the fundamental sub-unit of the seaweed polysaccharide fucoidan. The α(1→3) linked core of fucoidan is a suspected carbohydrate antigen for IgE-mediated allergy. Two structural features distinguish fucose from other six-carbon sugars present in mammals: the lack of a hydroxyl group on the carbon at the 6-position (C-6) (thereby making it a deoxy sugar) and the L -configuration. It is equivalent to 6-deoxy--galactose. In the fucose-containing glycan structures, fucosylated glycans, fucose can exist as a terminal modification or serve as an attachment point for adding other sugars. In human ''N''-linked glycans, fucose is most commonly linked α-1,6 to the reducing terminal β-''N''-acetylglucosamine. However, fucose at the non-reducing termini linked α-1,2 to galactose forms the H antigen, the substructure o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
L-fucose Isomerase
In enzymology, a L-fucose isomerase () is an enzyme that catalyzes the chemical reaction :L-fucose \rightleftharpoons L-fuculose Hence, this enzyme has one substrate, L-fucose, and one product, L-fuculose. This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is L-fucose aldose-ketose-isomerase. This enzyme participates in fructose and mannose metabolism. The enzyme is a hexamer, forming the largest structurally known ketol isomerase, and has no sequence or structural similarity with other ketol isomerases. The structure was determined by X-ray crystallography at 2.5 Angstrom resolution. Each subunit of the hexameric enzyme is wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta- sheets with surrounding alpha helices An alpha helix (or α-helix) is a sequence of amino acids in a protein that are twisted in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |