The
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
L-fuculose-phosphate aldolase ()
catalyzes
Catalysis () is the increase in rate of a chemical reaction due to an added substance known as a catalyst (). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quick ...
the
chemical reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
:
L-fuculose-1-phosphate
glycerone phosphate
[Glycerone phosphate is often known as dihydroxyacetone phosphate.] + (''S'')-lactaldehyde
This enzyme belongs to the family of
lyase
In biochemistry, a lyase is an enzyme that catalyzes the breaking (an elimination reaction) of various chemical bonds by means other than hydrolysis (a substitution reaction) and oxidation
Redox ( , , reduction–oxidation or oxidatio ...
s, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The
systematic name
A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivi ...
of this enzyme class is L-fuculose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming). Other names in common use include L-fuculose 1-phosphate aldolase, fuculose aldolase, and L-fuculose-1-phosphate lactaldehyde-lyase. This enzyme participates in
fructose
Fructose (), or fruit sugar, is a Ketose, ketonic monosaccharide, simple sugar found in many plants, where it is often bonded to glucose to form the disaccharide sucrose. It is one of the three dietary monosaccharides, along with glucose and gal ...
and
mannose metabolism
Mannose is a sugar with the formula , which sometimes is abbreviated Man. It is one of the monomers of the aldohexose series of carbohydrates. It is a C-2 epimer of glucose. Mannose is important in human metabolism, especially in the glycosylation ...
.
Structural studies
As of late 2007, 20
structures
A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as ...
have been solved for this class of enzymes, with
PDB accession codes , , , , , , , , , , , , , , , , , , , and .
See also
*
Fuculose
Fuculose or 6-deoxy-tagatose is a ketohexose deoxy sugar
Deoxy sugars are sugars that have had a hydroxyl group replaced with a hydrogen atom.
Examples include:
* Deoxyribose, or 2-deoxy-D-ribose, a constituent of DNA
* Fucose, or 6-deoxy-L-g ...
*
L-Fuculose kinase
References
*
*
*
EC 4.1.2
Enzymes of known structure
{{4.1-enzyme-stub