|
Friulimicin
Friulimicin B is a lipopeptide antibiotic produced by ''Actinoplanes friuliensis ''Actinoplanes friuliensis'' is a species of bacteria that produces lipopeptide antibiotics with peptidoglycan Peptidoglycan or murein is a unique large macromolecule, a polysaccharide, consisting of sugars and amino acids that forms a mesh-li ...''. It includes the unusual amino acid methylaspartate. References {{reflist Antibiotics Lipopeptides Cyclic peptides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
L-threo-3-methylaspartate
-''threo''-3-Methylaspartate is an unusual amino acid formed by glutamate mutase and can be metabolised by methylaspartate ammonia-lyase. It is found in the structures of the antibiotics friulimicin and vicenistatin and in carbon metabolism of haloarchaea Haloarchaea (halophilic archaea, halophilic archaebacteria, halobacteria) are a class of prokaryotic archaea under the phylum Euryarchaeota, found in water saturated or nearly saturated with salt. 'Halobacteria' are now recognized as archaea r ... ( Methylaspartate cycle). References {{DEFAULTSORT:Methylaspartate, L-threo-3- Aspartic acids ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actinoplanes Friuliensis
''Actinoplanes friuliensis'' is a species of bacteria that produces lipopeptide antibiotics with peptidoglycan Peptidoglycan or murein is a unique large macromolecule, a polysaccharide, consisting of sugars and amino acids that forms a mesh-like layer (sacculus) that surrounds the bacterial cytoplasmic membrane. The sugar component consists of alternating ... synthesis-inhibiting activity, called friulimicins. References Further reading * * External links *LPSN Micromonosporaceae Ba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipopeptide
A lipopeptide is a molecule consisting of a lipid connected to a peptide. They are able to self-assemble into different structures. Many bacteria produce these molecules as a part of their metabolism, especially those of the genus ''Bacillus'', ''Pseudomonas'' and '' Streptomyces''. Certain lipopeptides are used as antibiotics. Due to the structural and molecular properties such as the fatty acid chain, it poses the effect of weakening the cell function or destroying the cell. Other lipopeptides are toll-like receptor Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane protein, single-spanning receptor (biochemistry), receptors usually expressed on sentinel cells such as macrophages ... agonists. Certain lipopeptides can have strong antifungal and hemolytic activities. It has been demonstrated that their activity is generally linked to interactions with the plasma membrane, and sterol components of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotics
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy, treatment and antibiotic prophylaxis, prevention of such infections. They may either bactericide, kill or bacteriostatic agent, inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the ones which cause the common cold or influenza. Drugs which inhibit growth of viruses are termed antiviral drugs or antivirals. Antibiotics are also not effective against fungi. Drugs which inhibit growth of fungi are called antifungal drugs. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek language, Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipopeptides
A lipopeptide is a molecule consisting of a lipid connected to a peptide. They are able to self-assemble into different structures. Many bacteria produce these molecules as a part of their metabolism, especially those of the genus ''Bacillus'', ''Pseudomonas'' and ''Streptomyces''. Certain lipopeptides are used as antibiotics. Due to the structural and molecular properties such as the fatty acid chain, it poses the effect of weakening the cell function or destroying the cell. Other lipopeptides are toll-like receptor agonists. Certain lipopeptides can have strong antifungal and hemolytic activities. It has been demonstrated that their activity is generally linked to interactions with the plasma membrane, and sterol components of the plasma membrane could play a major role in this interaction. It is a general trend that adding a lipid group of a certain length (typically C10–C12) to a lipopeptide will increase its bactericidal activity. Lipopeptides with a higher amount of carbon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
