|
Firsocostat
Firsocostat is an acetyl-CoA carboxylase inhibitor that functions in the liver. Its original designation was GS-0976. It was discovered by Nimbus Therapeutics. The drug is under development by Gilead as a treatment for non-alcoholic fatty liver disease An alcohol-free or non-alcoholic drink, also known as a temperance drink, is a version of an alcoholic drink made without alcohol, or with the alcohol removed or reduced to almost zero. These may take the form of a non-alcoholic mixed drink or n .... References {{Reflist 2-Methoxyphenyl compounds Carboxylic acids Oxazoles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetyl-CoA Carboxylase
Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme () that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes and in the chloroplasts of most plants and algae, whereas it is a large, multi-domain enzyme in the cytoplasm of most eukaryotes. The most important function of ACC is to provide the malonyl-CoA substrate for the biosynthesis of fatty acids. The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. The human genome contains the genes for two different ACCs—'' ACACA'' and '' ACACB''. Structure Prokaryotes and plants have multi-subunit ACCs composed of several polypeptides. Biotin carboxylase (BC) activity, biotin carboxyl carrier protein (BCCP), and carboxyl transferase (CT) activity are each contained on a differ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nimbus Therapeutics
Nimbus, from the Latin for "dark cloud", is an outdated term for the type of cloud now classified as the nimbostratus cloud. Nimbus also may refer to: Arts and entertainment * Halo (religious iconography), also known as ''Nimbus'', a ring of light surrounding a person in a piece of art * ''Nimbus'' (literary magazine), published in London (1951–58) * Nimbus 2000, a flying broom from the ''Harry Potter'' series * ''Nimbus'', a spaceship captained by Zapp Brannigan in the animated series ''Futurama'' * Nimbus III, a planet in the movie '' Star Trek V: The Final Frontier'' * Nimbus, a character in the video game ''Tornado Outbreak'' * Nimbus, a type of guided missile in the video game '' Ace Combat 6: Fires of Liberation'' * Nimbus, a flying cloud from the ''Dragon Ball'' series * Mr. Nimbus, Rick's arch-nemesis in the series ''Rick and Morty'' *"Nimbus", a song by 808 State featured on their 1992 single "Timebomb" and also featured on their 1993 album ''Gorgeous'' *Nimbus, a 2010 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gilead
Gilead or Gilad (, ; ''Gilʿāḏ'', , ''Jalʻād'') is the ancient, historic, biblical name of the mountainous northern part of the region of Transjordan.''Easton's Bible Dictionary''''Galeed''/ref> The region is bounded in the west by the Jordan River, in the north by the deep ravine of the river Yarmouk and the region of Bashan, and in the southwest by what were known during antiquity as the " plains of Moab", with no definite boundary to the east. In some cases, "Gilead" is used in the Bible to refer to all the region east of the Jordan River. Gilead is situated in modern-day Jordan, corresponding roughly to the Irbid, Ajloun, Jerash and Balqa Governorates. Etymology Gilead is explained in the Hebrew Bible as derived from the Hebrew words , which in turn comes from ('heap, mound, hill') and ('witness, testimony'). If that is the case, Gilead means 'heap f stonesof testimony'. There is also an alternative theory that it means 'rocky region'. From its mountainous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non-alcoholic Fatty Liver Disease
An alcohol-free or non-alcoholic drink, also known as a temperance drink, is a version of an alcoholic drink made without alcohol, or with the alcohol removed or reduced to almost zero. These may take the form of a non-alcoholic mixed drink or non-alcoholic beer, and are widely available where alcoholic drinks are sold. Scientific definition Low-alcoholic drink Sparkling apple cider, soft drinks, and juice naturally contain trace amounts or no alcohol. Some fresh orange juices are above the UK 'alcohol free' limit of 0.05% ABV, as are some yogurts and rye bread. Ethanol distillation is used to separate alcoholic drinks into what are advertised as non-alcoholic drinks and spirits. Distilled wine produces low alcohol wine and brandy (from brandywine, derived from Dutch ''brandewijn'', "burning wine"). Distilled beer may be used to produce low-alcohol beer and whisky. However, alcoholic drinks cannot be further purified to 0.00% alcohol by volume by distillation, although sev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carboxylic Acids
In organic chemistry, a carboxylic acid is an organic acid that contains a carboxyl group () attached to an Substituent, R-group. The general formula of a carboxylic acid is often written as or , sometimes as with R referring to an organyl group (e.g., alkyl, alkenyl, aryl), or hydrogen, or other groups. Carboxylic acids occur widely. Important examples include the amino acids and fatty acids. Deprotonation of a carboxylic acid gives a carboxylate anion. Examples and nomenclature Carboxylic acids are commonly identified by their trivial names. They often have the suffix ''-ic acid''. IUPAC-recommended names also exist; in this system, carboxylic acids have an ''-oic acid'' suffix. For example, butyric acid () is butanoic acid by IUPAC guidelines. For nomenclature of complex molecules containing a carboxylic acid, the carboxyl can be considered position one of the parent chain even if there are other substituents, such as 3-chloropropanoic acid. Alternately, it can be named ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
