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Exscalate4Cov
Exscalate4Cov was a Public–private partnership, public-private consortium supported by the Horizon Europe program from the European Union, aimed at leveraging high-performance computing (HPC) as a response to the coronavirus pandemic. The project utilized high-throughput, extreme-scale, computer-aided drug design software to conduct experiments. The Exsclate4Cov project, which stands for ''EXaSCale smArt pLatform Against paThogEns for Corona Virus'', was coordinated by Dompé Farmaceutici and involved 17 participants. It was part of the Horizon 2020 ''SOCIETAL CHALLENGES - Health, demographic change and well-being'' founding funding''.'' The project conducted one of the largest virtual screening and drug repositioning experiments, identifying a potentially effective molecule against SARS-CoV-2. Context Background Drug discovery can be a long and costly process, often taking years and requiring substantial financial investment. Pharmaceutical companies have large dat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Repositioning
Drug repositioning (also called drug repurposing) involves the investigation of existing drugs for new therapeutic purposes. Repurposing achievements Repurposing generics can have groundbreaking effects for patients: 35% of 'transformative' drugs approved by the US FDA are repurposed products. Repurposing is especially relevant for rare or neglected diseases. A number of successes have been achieved, the foremost including sildenafil (Viagra) for erectile dysfunction and pulmonary hypertension and thalidomide for leprosy and multiple myeloma. Clinical trials have been performed on posaconazole and ravuconazole for Chagas disease. Other antifungal agents clotrimazole and ketoconazole have been investigated for anti- trypanosome therapy. Successful repositioning of antimicrobials has led to the discovery of broad-spectrum therapeutics, which are effective against multiple infection types. Strategy Drug repositioning is a "universal strategy" for neglected diseases due to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
