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Enterovirus 111
''Enterovirus'' is a genus of Positive sense#RNA sense in viruses, positive-sense single-stranded RNA viruses associated with several human and mammalian diseases. Enteroviruses are named by their transmission-route through the intestine ('enteric' meaning intestinal). Serologic studies have distinguished 71 human enterovirus serotypes on the basis of antibody neutralization tests. Additional antigenic variants have been defined within several of the serotypes on the basis of reduced or nonreciprocal cross-neutralization between variant strains. On the basis of their pathogenesis in humans and animals, the enteroviruses were originally classified into four groups, polioviruses, Coxsackie A viruses (CA), Coxsackie B viruses (CB), and echoviruses, but it was quickly realized that there were significant overlaps in the biological properties of viruses in the different groups. Enteroviruses isolated more recently are named with a system of consecutive numbers: Enterovirus 68, EV-D68, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enterovirus A71
Enterovirus 71 (EV71), also known as Enterovirus A71 (EV-A71), is a virus of the genus ''Enterovirus'' in the '' Picornaviridae'' family, notable for its role in causing epidemics of severe neurological disease and hand, foot, and mouth disease in children. It was first isolated and characterized from cases of neurological disease in California in 1969. Enterovirus 71 infrequently causes polio-like syndrome permanent paralysis. Evolution This virus is a member of the enterovirus species A. Species A was formerly assigned to the genus ''Rhinovirus''. This virus appears to have evolved recently with the first known strain isolated in 1965. It was associated with an outbreak of neurological disease in the United States in 1969. It then spread to Europe with outbreaks there in Bulgaria (1975) and Hungary (1978). It has since spread to various Asian countries where it has been responsible for several outbreaks, most recently in Cambodia (2012). The strains fall into six genogroup ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fecal–oral Route
The fecal–oral route (also called the oral–fecal route or orofecal route) describes a particular route of transmission of a disease wherein pathogens in fecal particles pass from one person to the mouth of another person. Main causes of fecal–oral disease transmission include lack of adequate sanitation (leading to open defecation), and poor hygiene practices. If soil or water bodies are polluted with fecal material, humans can be infected with waterborne diseases or soil-transmitted diseases. Fecal contamination of food is another form of fecal-oral transmission. Washing hands properly after changing a baby's diaper or after performing anal hygiene can prevent foodborne illness from spreading..Toilet flushing & subsequent inhaled aerosols is another potential route. The common factors in the fecal-oral route can be summarized as five Fs: fingers, flies, fields, fluids, and food. Diseases caused by fecal-oral transmission include typhoid, cholera, polio, hepat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA Viruses
''Orthornavirae'' is a kingdom of viruses that have genomes made of ribonucleic acid (RNA), including genes which encode an RNA-dependent RNA polymerase (RdRp). The RdRp is used to transcribe the viral RNA genome into messenger RNA (mRNA) and to replicate the genome. Viruses in this kingdom share a number of characteristics which promote rapid evolution, including high rates of genetic mutation, recombination, and reassortment. Viruses in ''Orthornavirae'' belong to the realm ''Riboviria''. They are descended from a common ancestor that may have been a non-viral molecule that encoded a reverse transcriptase instead of an RdRp for replication. The kingdom is subdivided into seven phyla that separate member viruses based on their genome type, host range, and genetic similarity. Viruses with three genome types are included: positive-strand RNA viruses, negative-strand RNA viruses, and double-stranded RNA viruses. Many of the most widely known viral diseases are caused by membe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Picornavirus
Picornaviruses are a group of related Viral envelope, nonenveloped RNA viruses which infect vertebrates including fish, mammals, and birds. They are viruses that represent a large family of small, Positive-sense single-stranded RNA virus, positive-sense, single-stranded RNA viruses with a 30 nm Icosahedron, icosahedral capsid. The viruses in this family can cause a range of diseases including the common cold, poliomyelitis, meningitis, hepatitis, and paralysis. Picornaviruses constitute the Subfamily, family ''Picornaviridae'', order ''Picornavirales'', and realm ''Riboviria''. There are 159 species in this family, assigned to 68 genera, most of which belong to 5 subfamilies. Notable examples are genera ''Enterovirus'' (including ''Rhinovirus'' and ''Poliovirus''), ''Aphthovirus'', ''Cardiovirus'', and ''Hepatovirus''. Etymology The name "picornavirus" has a dual etymology. Firstly, the name derives from ''picorna''- which is an acronym for "''p''oliovirus, ''i''nsensiti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acute Flaccid Myelitis
Acute flaccid myelitis (AFM) is a serious condition of the spinal cord. Symptoms include rapid onset of arm or leg weakness and decreased reflexes. Difficulty moving the eyes, speaking, or swallowing may also occur. Occasionally, numbness or pain may be present. Complications can include trouble breathing. The cause of most cases is unclear as of 2018. More than 90% of recent cases have followed a mild viral infection such as from enteroviruses. While polio can cause AFM, since 2014, it has not been involved in cases in the United States. The underlying mechanism involves damage to the spinal cord's grey matter. Diagnosis may be supported by medical imaging of the spine, nerve conduction studies, and cerebrospinal fluid testing. Treatment involves supportive care. Physical therapy may be recommended. Occasionally, mechanical ventilation is required to support breathing. Outcomes are variable. The condition is rare and occurs most commonly in children. Fewer than one in 500 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flaccid Paralysis
Flaccid paralysis is a neurological condition characterized by weakness or paralysis and reduced muscle tone without other obvious cause (e.g., trauma). This abnormal condition may be caused by disease or by trauma affecting the nerves associated with the involved muscles. For example, if the somatic nerves to a skeletal muscle are severed, then the muscle will exhibit flaccid paralysis. When muscles enter this state, they become limp and cannot contract. This condition can become fatal if it affects the respiratory muscles, posing the threat of suffocation. It also occurs in the spinal shock stage in complete transection of the spinal cord occurring in injuries such as gunshot wounds.Saladin, Kenneth S. Anatomy & Physiology: The Unity of Form and Function. McGraw-Hill. 6th Edition. 2012. Causes Polio and other viruses The term ''acute flaccid paralysis'' (AFP) is often used to describe an instance with a sudden onset, as might be found with polio. AFP is the most co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sepsis
Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage of sepsis is followed by suppression of the immune system. Common signs and symptoms include fever, tachycardia, increased heart rate, hyperventilation, increased breathing rate, and mental confusion, confusion. There may also be symptoms related to a specific infection, such as a cough with pneumonia, or dysuria, painful urination with a pyelonephritis, kidney infection. The very young, old, and people with a immunodeficiency, weakened immune system may not have any symptoms specific to their infection, and their hypothermia, body temperature may be low or normal instead of constituting a fever. Severe sepsis may cause organ dysfunction and significantly reduced blood flow. The presence of Hypotension, low blood pressure, high blood Lactic acid, lactate, or Oliguria, low urine output may suggest poor blood flow. Se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neonatal
In common terminology, a baby is the very young offspring of adult human beings, while infant (from the Latin word ''infans'', meaning 'baby' or 'child') is a formal or specialised synonym. The terms may also be used to refer to Juvenile (organism), juveniles of other organisms. A newborn is, in colloquial use, a baby who is only hours, days, or weeks old; while in medical contexts, a newborn or neonate (from Latin, ''neonatus'', newborn) is an infant in the first 28 days after Human birth, birth (the term applies to Preterm birth, premature, Pregnancy#Term, full term, and Postterm pregnancy, postmature infants). Infants born prior to 37 weeks of gestation are called "premature", those born between 39 and 40 weeks are "full term", those born through 41 weeks are "late term", and anything beyond 42 weeks is considered "post term". Before birth, the offspring is called a fetus. The term ''infant'' is typically applied to very young children under one year of age; however, defini ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myocarditis
Myocarditis is inflammation of the cardiac muscle. Myocarditis can progress to inflammatory cardiomyopathy when there is associated ventricular remodeling and cardiac dysfunction due to chronic inflammation. Symptoms can include shortness of breath, chest pain, Exercise intolerance, decreased ability to exercise, and an irregular heartbeat. The duration of problems can vary from hours to months. Complications may include heart failure, due to dilated cardiomyopathy or cardiac arrest. Myocarditis is most often due to a viral infection. Other causes include bacterial infections, certain medications, toxins and autoimmune disorders. A diagnosis may be supported by an electrocardiogram (ECG), increased troponin, cardiac magnetic resonance imaging, heart MRI, and occasionally a heart biopsy. An echocardiogram, ultrasound of the heart is important to rule out other potential causes, such as valvular heart disease, heart valve problems. Treatment depends on both the severity and the c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aseptic Meningitis
Aseptic meningitis is the inflammation of the meninges, a membrane covering the brain and spinal cord, in patients whose cerebral spinal fluid test result is negative with routine bacterial cultures. Aseptic meningitis is caused by viruses, mycobacteria, spirochetes, fungi, medications, and cancer malignancies. The testing for both meningitis and aseptic meningitis is mostly the same. A cerebrospinal fluid sample is taken by lumbar puncture and is tested for leukocyte levels to determine if there is an infection and goes on to further testing to see what the actual cause is. The symptoms are the same for both meningitis and aseptic meningitis but the severity of the symptoms and the treatment can depend on the certain cause. The most common cause of aseptic meningitis is by viral infection. Other causes may include side-effects from drugs and connective tissue disorders. Signs and symptoms Aseptic meningitis is a disease that can depend on the patient's age, however, researc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conjunctivitis
Conjunctivitis, also known as pink eye or Madras eye, is inflammation of the conjunctiva, the thin, clear layer that covers the white surface of the eye and the inner eyelid. It makes the eye appear pink or reddish. Pain, burning, scratchiness, or itchiness may occur. The affected eye may have increased tears or be "stuck shut" in the morning. Swelling of the sclera may also occur. Itching is more common in cases due to allergies. Conjunctivitis can affect one or both eyes. The most common infectious causes in adults are viral, whereas in children bacterial causes predominate. The viral infection may occur along with other symptoms of a common cold. Both viral and bacterial cases are easily spread between people. Allergies to pollen or animal hair are also a common cause. Diagnosis is often based on signs and symptoms. Occasionally, a sample of the discharge is sent for microbial culture, culture. Prevention is partly by handwashing. Treatment depends on the underlying cause ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
