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Debiopharm
Debiopharm is a Privately held company, privately-held Switzerland, Swiss biopharmaceutical company mainly active in drug development, development and Clinical trial, clinical testing of Drug discovery, drug candidates. It was founded in 1979 by Rolland-Yves Mauvernay. The company now has 2 sites in Lausanne and in Martigny, Switzerland with new building expansion projects in both locations. History :fr:Rolland-Yves Mauvernay, Rolland-Yves Mauvernay founded Debiopharm in 1979 in Martigny, Switzerland. In 1981, the Cytotech laboratory was created and after a few years it became Debio Recherche Pharmaceutique (R.P.), then Debiopharm Research & Manufacturing. Initially, the company worked on interferon and, in 1982, it began to focus on triptorelin, after having acquired the rights for its development from Tulane University. Triptorelin is a Gonadotropin-releasing hormone agonist (GnRH agonist) that has been approved for several indications, including advanced prostate cancer and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triptorelin
Triptorelin, sold under the brand name Decapeptyl among others, is a medication that acts as an agonist analog of gonadotropin-releasing hormone, repressing expression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It is a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2) and a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salt (chemistry), salts. Primary indications include endometriosis, for the reduction of uterine fibroids, to treat prostate cancer, and to treat male hypersexuality with severe sexual deviation. The drug has also been used off label to delay puberty in patients with gender dysphoria. It was patented in 1975 and approved for medical use in 1986. It is on the WHO Model List of Essential Medicines, World Health Organization's List of Essential Medicines. Medical uses Triptorelin is used to treat prostate cancer as part of androgen deprivation therapy. Another common use in the United King ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biopharmaceutical
A biopharmaceutical, also known as a biological medical product, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources. Different from totally synthesized pharmaceuticals, they include vaccines, whole blood, blood components, allergenics, somatic cells, gene therapies, tissues, recombinant therapeutic protein, and living medicines used in cell therapy. Biopharmaceuticals can be composed of sugars, proteins, nucleic acids, or complex combinations of these substances, or may be living cells or tissues. They (or their precursors or components) are isolated from living sources—human, animal, plant, fungal, or microbial. They can be used in both human and animal medicine. Terminology surrounding biopharmaceuticals varies between groups and entities, with different terms referring to different subsets of therapeutics within the general biopharmaceutical category. The term biologics is often used more res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endometriosis
Endometriosis is a disease in which Tissue (biology), tissue similar to the endometrium, the lining of the uterus, grows in other places in the body, outside the uterus. It occurs in women and a limited number of other female mammals. Endometrial tissue most often grows on or around reproductive organs such as the ovaries and fallopian tubes, on the outside surface of the uterus, or the tissues surrounding the uterus and the ovaries (peritoneum). It can also grow on other organs in the pelvic region like the Gastrointestinal tract, bowels, stomach, bladder, or the cervix. Rarely, it can also occur in other parts of the body. Symptoms can be very different from person to person, varying in range and intensity. About 25% of individuals have no symptoms, while for some it can be a debilitating disease. Common symptoms include pelvic pain, Heavy menstrual bleeding, heavy and Dysmenorrhea, painful periods, pain with bowel movements, Dysuria, painful urination, Dyspareunia, pain dur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inflammatory Disease
Inflammation (from ) is part of the biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or Irritation, irritants. The five cardinal signs are heat, pain, redness, swelling, and Functio laesa, loss of function (Latin ''calor'', ''dolor'', ''rubor'', ''tumor'', and ''functio laesa''). Inflammation is a generic response, and therefore is considered a mechanism of innate immune system, innate immunity, whereas adaptive immune system, adaptive immunity is specific to each pathogen. Inflammation is a protective response involving immune cells, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out damaged cells and tissues, and initiate tissue repair. Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. bacteria) and compromise the survival of the organism. However inflammation can also have negative effects. Too much inflammat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autoimmune Disease
An autoimmune disease is a condition that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the body as if they were foreign organisms. It is estimated that there are more than 80 recognized autoimmune diseases, with recent scientific evidence suggesting the existence of potentially more than 100 distinct conditions. Nearly any body part can be involved. Autoimmune diseases are a separate class from autoinflammatory diseases. Both are characterized by an immune system malfunction which may cause similar symptoms, such as rash, swelling, or fatigue, but the cardinal cause or mechanism of the diseases is different. A key difference is a malfunction of the innate immune system in autoinflammatory diseases, whereas in autoimmune diseases there is a malfunction of the adaptive immune system. Symptoms of autoimmune diseases can significantly vary, primarily based on the specific type of the d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale University
Yale University is a Private university, private Ivy League research university in New Haven, Connecticut, United States. Founded in 1701, Yale is the List of Colonial Colleges, third-oldest institution of higher education in the United States, and one of the nine colonial colleges chartered before the American Revolution. Yale was established as the Collegiate School in 1701 by Congregationalism in the United States, Congregationalist clergy of the Connecticut Colony. Originally restricted to instructing ministers in theology and sacred languages, the school's curriculum expanded, incorporating humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first Doctor of Philosophy, PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew rapidly after 1890 due to the expansion of the physical campus and its scientif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Le Temps
' (, ) is a Swiss French-language daily newspaper published in Berliner format in Geneva by Le Temps SA. The paper was launched in 1998, formed out of the merger of two other newspapers, and (the former being a merger of two other papers), as those papers were facing financial problems. It is the sole nationwide French-language non-specialised daily newspaper of Switzerland. Since 2021, it has been owned by Fondation Aventinus, a not-for-profit organisation. is considered a newspaper of record in Switzerland. History Predecessor papers The paper's three predecessors were the (founded 1798), the (founded 1826), and (founded 1991). The ' and the ' were merged in 1991 as the , which was partially motivated by those paper's financial issues as well as the impending creation of .' Due to financial issues, it was proposed that the ' and merge in 1996. The editorial staff of both papers met, but this was declined by publisher Edipresse as it would have resulted in lay ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaud
Vaud ( ; , ), more formally Canton of Vaud, is one of the 26 cantons forming the Swiss Confederation. It is composed of ten districts; its capital city is Lausanne. Its coat of arms bears the motto "Liberté et patrie" on a white-green bicolour. Vaud is the third-largest Swiss canton by population and fourth by size. It is located in Romandy, the partially French-speaking western part of the country, and borders the canton of Neuchâtel to the north, the cantons of Fribourg and Bern to the east, the canton of Valais to the south, the canton of Geneva to the south-west, and France to the west. The geography of the canton includes all three natural regions of Switzerland: the Jura Mountains, the Swiss Plateau, and the (Swiss) Alps. It also includes some of the largest lakes of the country: Lake Geneva and Lake Neuchâtel. It is a major tourist destination, renowned for its landscapes and gastronomy. The largest city is Lausanne, followed by Yverdon-les-Bains and Montreux. As o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jean Tschumi
Jean André Tschumi (born 14 February 1904 Plainpalaisp. 117 – 25 January 1962He was discovered by customs officers at Vallorbe, in an overnight train coming from Paris)p. 131) was a Swiss architect and professor at the . A member of the modern movement, Jean Tschumi is known for his buildings for Sandoz (laboratory, factory), Nestlé (pavilions at various international fairs, headquarters), la Mutuelle Vaudoise (headquarters), as well as for some of his projects (underground Paris souterrain, observation tower, etc.). Biography Jean André Tschumi was born on 14 February 1904 in Plainpalais, in the Canton of Geneva, Switzerland. His mother, Maria (maiden name Krummnacker), born in 1873, was from Schüpfheim. His father, Johann, born in 1871, was a woodworker from Bern. In 1915, at the age of 11, Jean Tschumi began drawing under the guidance of his father, who also taught him the basics of woodworking. Shortly before obtaining his primary school certificate in Renens in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Colorectal Cancer
Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the Colon (anatomy), colon or rectum (parts of the large intestine). Signs and symptoms may include Lower gastrointestinal bleeding, blood in the stool, a change in bowel movements, weight loss, abdominal pain and fatigue. Most colorectal cancers are due to lifestyle factors and genetic disorders. Risk factors include diet, obesity, smoking, and lack of physical activity. Dietary factors that increase the risk include red meat, processed meat, and alcohol (drug), alcohol. Another risk factor is inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases. It typically starts as a adenoma, benign tumor, often in the form of a colorectal poly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Standard Treatment
The standard treatment, also known as the standard of care, is the medical treatment that is normally provided to people with a given condition. In many scientific studies, the control group receives the standard treatment rather than a placebo while a treatment group receives the experimental treatment. After the clinical trial, researchers compare the outcomes of the two groups to see if the experimental treatment is better than, as good as or not as beneficial as the standard treatment. Active (positive) concurrent control In an active control or positive control trial, subjects are randomly assigned to the test treatment or to an active control treatment. Such clinical trials are usually double-blind, but this is not always possible; many oncology trials, for example, are considered difficult or impossible to blind because of different regimens, different routes of administration, and different toxicities. Active control trials can have two distinct objectives with respect ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
