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David M. Sabatini
David M. Sabatini (born January 27, 1968) is an American scientist and a former professor of biology at the Massachusetts Institute of Technology. From 2002 to 2021, he was a member of the Whitehead Institute for Biomedical Research. He was also an investigator of the Howard Hughes Medical Institute from 2008 to 2021 and was elected to the National Academy of Sciences in 2016. He is known for his contributions in the areas of cell signaling and cancer metabolism, most notably the co-discovery of mTOR. In 2021 and 2022, Sabatini was fired from the Howard Hughes Medical Institute and resigned his positions at the Whitehead Institute and the Massachusetts Institute of Technology, following allegations of sexual harassment. Sabatini denies the allegations. Biography David M. Sabatini was born and raised in New York to David D. Sabatini and Zulema Sabatini, both Argentine immigrants from Buenos Aires. He obtained his B.S. from Brown University followed by both his MD and his Ph.D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York (state)
New York, also called New York State, is a U.S. state, state in the northeastern United States. Bordered by New England to the east, Canada to the north, and Pennsylvania and New Jersey to the south, its territory extends into both the Atlantic Ocean and the Great Lakes. New York is the List of U.S. states and territories by population, fourth-most populous state in the United States, with nearly 20 million residents, and the List of U.S. states and territories by area, 27th-largest state by area, with a total area of . New York has Geography of New York (state), a varied geography. The southeastern part of the state, known as Downstate New York, Downstate, encompasses New York City, the List of U.S. cities by population, most populous city in the United States; Long Island, with approximately 40% of the state's population, the nation's most populous island; and the cities, suburbs, and wealthy enclaves of the lower Hudson Valley. These areas are the center of the expansive New ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field in the United States. Member of the National Academy of Sciences, Members of the National Academy of Sciences serve ''pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Congress legislated and President Abraham Lincoln signed an Act of Congress (1863) establishing the National Academy of Sciences as an independent, trusted nongovernmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FKBP12
Peptidyl-prolyl cis-trans isomerase FKBP1A is an enzyme that in humans is encoded by the ''FKBP1A'' gene. It is also commonly referred to as FKBP-12 or FKBP12 and is a member of a family of FK506-binding proteins ( FKBPs). Function The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same prote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Budding Yeast
''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungal microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have been originally isolated from the skin of grapes. It is one of the most intensively studied eukaryotic model organisms in molecular and cell biology, much like ''Escherichia coli'' as the model bacterium. It is the microorganism which causes many common types of fermentation. ''S. cerevisiae'' cells are round to ovoid, 5–10 μm in diameter. It reproduces by budding. Many proteins important in human biology were first discovered by studying their homologs in yeast; these proteins include cell cycle proteins, signaling proteins, and protein-processing enzymes. ''S. cerevisiae'' is currently the only yeast cell known to have Berkeley bodies present, which are involved in particular secretory pathways. Antibodies against ''S. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Easter Island
Easter Island (, ; , ) is an island and special territory of Chile in the southeastern Pacific Ocean, at the southeasternmost point of the Polynesian Triangle in Oceania. The island is renowned for its nearly 1,000 extant monumental statues, called ''moai'', which were created by the early Rapa Nui people. In 1995, UNESCO named Easter Island a World Heritage Site, with much of the island protected within Rapa Nui National Park. Experts differ on when the island's Polynesian inhabitants first reached the island. While many in the research community cited evidence that they arrived around the year 800, a 2007 study provided compelling evidence suggesting their arrival was closer to 1200. The inhabitants created a thriving and industrious culture, as evidenced by the island's numerous enormous stone ''moai'' and other artifacts. Land clearing for cultivation and the introduction of the Polynesian rat led to gradual deforestation. By the time of European arrival in 1722, the i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rapamycin
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ rejection, organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It is a mammalian target of rapamycin (mTOR) kinase inhibitor that reduces the sensitivity of T cells and B cells to interleukin-2 (IL-2), inhibiting their activity. This compound also has a use in cardiovascular drug-eluting stent technologies to inhibit restenosis. It is produced by the bacteria, bacterium ''Streptomyces hygroscopicus'' and was isolated for the first time in 1972, from samples of ''Streptomyces hygroscopicus'' found on Easter Island. The compound was originally named rapamycin after the native name of the island, Rapa Nui. Siro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prague
Prague ( ; ) is the capital and List of cities and towns in the Czech Republic, largest city of the Czech Republic and the historical capital of Bohemia. Prague, located on the Vltava River, has a population of about 1.4 million, while its Prague metropolitan area, metropolitan area is home to approximately 2.3 million people. Prague is a historical city with Romanesque architecture, Romanesque, Czech Gothic architecture, Gothic, Czech Renaissance architecture, Renaissance and Czech Baroque architecture, Baroque architecture. It was the capital of the Kingdom of Bohemia and residence of several Holy Roman Emperors, most notably Charles IV, Holy Roman Emperor, Charles IV (r. 1346–1378) and Rudolf II, Holy Roman Emperor, Rudolf II (r. 1575–1611). It was an important city to the Habsburg monarchy and Austria-Hungary. The city played major roles in the Bohemian Reformation, Bohemian and the Protestant Reformations, the Thirty Years' War and in 20th-century history a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Czech Academy Of Sciences
The Czech Academy of Sciences (abbr. CAS, , abbr. AV ČR) was established in 1992 by the Czech National Council as the Czech successor of the former Czechoslovak Academy of Sciences and its tradition goes back to the Royal Bohemian Society of Sciences (founded in 1784) and the Emperor Franz Joseph Czech Academy for Sciences, Literature and Arts (founded in 1890). The academy is the leading non-university public research institution in the Czech Republic. It conducts both fundamental and strategic applied research. It has three scientific divisions, namely the Division of Mathematics, Physics, and Earth science, Earth Sciences, Division of Chemistry, Chemical and life science, Life Sciences, and Division of Humanities and Social Sciences. The academy currently manages a network of sixty research institutes and five supporting units staffed by a total of 6,400 employees, over one half of whom are university-trained researchers and Ph.D. scientists. The Head Office of the academy a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bill Ackman
William Albert Ackman (born May 11, 1966) is an American billionaire hedge fund manager who is the founder and chief executive officer of Pershing Square Capital Management, a hedge fund management company. His investment approach has made him an Activist shareholder, activist investor. As of May 2025, Ackman's net worth was estimated at $9.1 billion by ''Forbes''. Ackman is a prolific philanthropist and signatory of The Giving Pledge, committing to give away at least 50% of his wealth by the end of his life to charitable causes. A longtime donor to Democratic Party (United States), Democratic candidates and organizations, Ackman endorsed Donald Trump in the 2024 United States presidential election. Ackman has expressed public support for Israel's actions in the Gaza war and has demanded the publication of the names of Harvard students involved in signing a letter condemning statements from Israeli officials. Early life and education Ackman was raised in Chappaqua, New York, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Free Press (Bari Weiss Media)
The Free Press (The FP, known as Common Sense between 2021–2022) is an American Internet-based media company based in Los Angeles, California, founded by Bari Weiss and Nellie Bowles. The newsletter was first published in 2021, and an associated media company was officially launched in 2022. History Origins Weiss and Bowles, then a reporter at ''The New York Times'', launched ''Common Sense'' as a newsletter on the Substack platform on January 12, 2021, after Weiss resigned from ''The Times''. Within a week, the newsletter had brought in $80,000 in annual subscription revenue. Weiss described ''Common Sense'' as a "newsletter for the 21st century". By October, the newsletter had more than 100,000 subscribers, including enough paying subscribers to hire a staff of five people. The newsletter was named after the political pamphlet of the same name by Thomas Paine. It covers politics, culture, and current events. In March 2022, Weiss raised between $1 million and $5 million to exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Medical School
Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the United States. It provides patient care, medical education, and research training through its 15 clinical affiliates and research institutes, including Massachusetts General Hospital (MGH), Boston Children's Hospital, Dana–Farber Cancer Institute, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Mount Auburn Hospital, McLean Hospital, Cambridge Health Alliance, The Baker Center for Children and Families, Spaulding Rehabilitation Hospital, and others. Harvard Medical School also partners with newer entities such as Harvard Catalyst, Broad Institute , Broad Institute of MIT and Harvard, Harvard Stem Cell Institute, the Center for Primary Care, and Wyss Institute for Biologically Inspired Engineering. History Harvard ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York University
New York University (NYU) is a private university, private research university in New York City, New York, United States. Chartered in 1831 by the New York State Legislature, NYU was founded in 1832 by Albert Gallatin as a Nondenominational Christianity, non-denominational all-male institution near New York City Hall, City Hall based on a curriculum focused on a secular education. The university moved in 1833 and has maintained its main campus in Greenwich Village surrounding Washington Square Park. Since then, the university has added an engineering school in Brooklyn's MetroTech Center and graduate schools throughout Manhattan. NYU is one of the largest private universities in the United States by enrollment, with a total of 51,848 enrolled students in 2021. It is one of the most applied-to schools in the country and admissions are considered selective. NYU's main campus in New York City is organized into ten undergraduate schools, including the New York University College ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
