Peptidyl-prolyl cis-trans isomerase FKBP1A is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''FKBP1A''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
It is also commonly referred to as FKBP-12 or FKBP12 and is a member of a family of
FK506-binding proteins (
FKBPs).
Function
The protein encoded by this gene is a member of the
immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a
cis-trans prolyl isomerase that binds the immunosuppressants
FK506 (tacrolimus) and
rapamycin
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ rejection, organ transplant rejection, treat a rare lung disease called lymphang ...
(sirolimus). It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels including the tetrameric skeletal muscle
ryanodine receptor
Ryanodine receptors (RyR) make up a class of high-conductance, intracellular calcium channels present in various forms, such as animal muscles and neurons. There are three major isoforms of the ryanodine receptor, which are found in different tissu ...
. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
Interactions
FKBP1A has been shown to
interact with:
*
GLMN,
*
ITPR1
Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ''ITPR1'' gene.
Interactions
ITPR1 has been shown to interact with:
* AHCYL1,
* CA8,
* EPB41L1
* FKBP1A,
* MRVI1,
* PRKG1,
* RHOA
Tran ...
*
KIAA1303
Regulatory-associated protein of mTOR also known as raptor or KIAA1303 is an Signal transducing adaptor protein, adapter protein that is encoded in humans by the ''RPTOR'' gene. Two messenger RNA, mRNAs from the gene have been identified that en ...
,
[
* ]Mammalian target of rapamycin
The mammalian target of sirolimus, rapamycin (mTOR), also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the ''M ...
,RYR1
Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is one of a class of ryanodine receptors and a protein found primarily in skeletal muscle. In humans, it is encoded by th ...
,TGF beta receptor 1
Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta receptor family for the TGF beta superfamily of signaling ligands. ''TGFBR1'' is its huma ...
.
References
Further reading
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EC 5.2.1