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Daigremontianin
Daigremontianin is a bufadienolide. Bufadienolides are steroids and cardiac glycoside aglycones (meaning that they bind with carbohydrates to form cardiac glycosides) that are similar to cardenolides, differing only in the structure of the C-17 substituent on the D ring. This chemical has been found to be toxic in experiments on mice. It is one of five bufadienolides that have been isolated from '' Kalanchoe daigremontiana''. Toxicity Crassulaceans are one of the prime sources of bufadienolide cardiac glycosides (including daigremontianin) responsible for an estimated 33% of cattle mortalities related to plant poisoning in South Africa. Crassulacean bufadienolides cause cardiac poisoning, but repeated small doses cause a condition called cotyledonosis, an intoxication affecting nervous and muscular systems of small animals, particularly, sheep in the Karoo The Karoo ( ; from the Afrikaans borrowing of the South Khoekhoe Khoemana (also known as !Orakobab or Korana) word is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiac Glycoside
Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. Their beneficial medical uses include treatments for congestive heart failure and cardiac arrhythmias; however, their relative toxicity prevents them from being widely used. Most commonly found as defensive poisons in several plant genera such as ''Digitalis'' (the foxgloves) and '' Asclepias'' (the milkweeds), these compounds nevertheless have a diverse range of biochemical effects regarding cardiac cell function and have also been suggested for use in cancer treatment. Classification General structure The general structure of a cardiac glycoside consists of a steroid molecule attached to a sugar (glycoside) and an R group. The steroid nucleus consists of four fused rings to which other functional groups such as methyl, hydroxyl, and aldehyde groups can be attached to influence th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kalanchoe Daigremontiana
''Kalanchoe daigremontiana'', formerly known as ''Bryophyllum daigremontianum'' and commonly called mother of thousands, alligator plant or Mexican hat plant, is a succulent plant native to Madagascar. Like other members of '' Bryophyllum'' (now included in the genus ''Kalanchoe''), it can propagate vegetatively from plantlets that develop on its leaf margins, as well as through upshoots from lateral roots, and seeds. All parts of this species contain a very toxic steroid known as daigremontianin. It is often confused with ''Kalanchoe laetivirens'', ''Kalanchoe delagoensis'' and ''Kalanchoe × houghtonii''. The leaves of '' Kalanchoe laetivirens'' are completely green, while ''Kalanchoe daigremontiana'' has bands or spots on the back of leaves. The leaves of '' Kalanchoe delagoensis'' are linear, while ''Kalanchoe daigremontiana'' has lanceolate, oblong, ovate or triangular leaves. '' Kalanchoe × houghtonii'' is a hybrid between ''Kalanchoe daigremontiana'' and ''Kalanchoe d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufadienolide
Bufadienolide is a chemical compound with steroid structure. Its derivatives are collectively known as bufadienolides, including many in the form of bufadienolide glycosides (bufadienolides that contain structural groups derived from sugars). These are a type of cardiac glycoside, the other being the cardenolide glycosides. Both bufadienolides and their glycosides are toxic; specifically, they can cause an atrioventricular block, bradycardia (slow heartbeat), ventricular tachycardia (a type of rapid heartbeat), and possibly lethal cardiac arrest. Etymology The term derives from the toad genus '' Bufo'' that contains bufadienolide glycosides, the suffix ''-adien-'' that refers to the two double bonds in the lactone ring, and the ending ''-olide'' that denotes the lactone structure. Consequently, related structures with only one double bond are called ''bufenolides'', and the saturated equivalent is ''bufanolide''. Classification According to MeSH, bufadienolides and bufan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroids
A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signaling molecules. Examples include the lipid cholesterol, sex hormones estradiol and testosterone, anabolic steroids, and the anti-inflammatory corticosteroid drug dexamethasone. Hundreds of steroids are found in fungi, plants, and animals. All steroids are manufactured in cells from a sterol: cholesterol (animals), lanosterol ( opisthokonts), or cycloartenol (plants). All three of these molecules are produced via cyclization of the triterpene squalene. Structure The steroid nucleus ( core structure) is called gonane (cyclopentanoperhydrophenanthrene). It is typically composed of seventeen carbon atoms, bonded in four fused rings: three six-member cyclohexane rings (rings A, B and C in the first illus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aglycone
An aglycone (aglycon or genin) is the chemical compound remaining after the glycosyl group on a glycoside is replaced by a hydrogen atom. For example, the aglycone of a cardiac glycoside would be a steroid A steroid is an organic compound with four fused compound, fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes t ... molecule. Detection A way to identify aglycone is proposed to extract it from Agave spp. by using H-NMR and Heteronuclear multiple bond correlation (HMBC) experiments. The HMBC experiment can be combined with other techniques such as mass spectrometry to further examine the structure and the function of aglycone. Samples of glycones and glycosides from limonoids can be simultaneously quantified through a high performance liquid chromatography (HPLC) method, where a binary solvent system and a diode array detector separate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbohydrate
A carbohydrate () is a biomolecule composed of carbon (C), hydrogen (H), and oxygen (O) atoms. The typical hydrogen-to-oxygen atomic ratio is 2:1, analogous to that of water, and is represented by the empirical formula (where ''m'' and ''n'' may differ). This formula does not imply direct covalent bonding between hydrogen and oxygen atoms; for example, in , hydrogen is covalently bonded to carbon, not oxygen. While the 2:1 hydrogen-to-oxygen ratio is characteristic of many carbohydrates, exceptions exist. For instance, uronic acids and deoxy-sugars like fucose deviate from this precise stoichiometric definition. Conversely, some compounds conforming to this definition, such as formaldehyde and acetic acid, are not classified as carbohydrates. The term is predominantly used in biochemistry, functioning as a synonym for saccharide (), a group that includes sugars, starch, and cellulose. The saccharides are divided into four chemical groups: monosaccharides, disaccharides, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardenolide
A cardenolide is a type of steroid. Many plants contain derivatives, collectively known as cardenolides, including many in the form of cardenolide glycosides (cardenolides that contain structural groups derived from sugars). Cardenolide glycosides are often toxic; specifically, they are cardiac arrest, heart-arresting. Cardenolides are toxic to animals through inhibition of the enzyme Na+/K+-ATPase, Na+/K+-ATPase, which is responsible for maintaining the sodium and Potassium in biology, potassium ion gradients across the cell membranes. Etymology The term derives from ''card-'' "heart" (from Greek language, Greek καρδία ''kardiā'') and the suffix , referring to the lactone ring with double bond at C17. Cardenolides are a class of steroids (or aglycones if viewed as cardiac glycoside constituents), and cardenolides are a subtype of this class (see Wikipedia:MeSH D04#MeSH D04.808.155 --- cardenolides, MeSH D codes list). Structure Cardenolides are C(23)-steroids with methyl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crassulaceae
The Crassulaceae (, from Latin ''crassus'', thick), also known as the crassulas, the stonecrops or the orpine family, are a diverse Family (biology), family of dicotyledon angiosperms primarily characterized by succulent leaves and a form of photosynthesis known as crassulacean acid metabolism (CAM), in which plants photosynthesize in the daytime and exchange gases during the cooler temperatures of the night. The blossoms of crassulas generally have five floral parts. Crassulaceae are usually herbaceous, though there are some subshrubs, and relatively few trees or aquatic plants. The Crassulaceae is a medium-sized, monophyletic family in the core eudicots clade, along with the order Saxifragales, whose diversity has made infrafamilial classification very difficult. The family includes approximately 1,400 species and 34–35 genera—depending on the circumscription of the genus ''Sedum''—distributed over three subfamilies. Members of the Crassulaceae are found worldwide, though ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poison
A poison is any chemical substance that is harmful or lethal to living organisms. The term is used in a wide range of scientific fields and industries, where it is often specifically defined. It may also be applied colloquially or figuratively, with a broad sense. Whether something is considered a poison or not may depend on the amount, the circumstances, and what living things are present. Poisoning could be accidental or deliberate, and if the cause can be identified there may be ways to neutralise the effects or minimise the symptoms. In biology, a poison is a chemical substance causing death, injury or harm to organisms or their parts. In medicine, poisons are a kind of toxin that are delivered passively, not actively. In industry the term may be negative, something to be removed to make a thing safe, or positive, an agent to limit unwanted pests. In ecological terms, poisons introduced into the environment can later cause unwanted effects elsewhere, or in other pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
South Africa
South Africa, officially the Republic of South Africa (RSA), is the Southern Africa, southernmost country in Africa. Its Provinces of South Africa, nine provinces are bounded to the south by of coastline that stretches along the Atlantic Ocean, South Atlantic and Indian Ocean; to the north by the neighbouring countries of Namibia, Botswana, and Zimbabwe; to the east and northeast by Mozambique and Eswatini; and it encloses Lesotho. Covering an area of , the country has Demographics of South Africa, a population of over 64 million people. Pretoria is the administrative capital, while Cape Town, as the seat of Parliament of South Africa, Parliament, is the legislative capital, and Bloemfontein is regarded as the judicial capital. The largest, most populous city is Johannesburg, followed by Cape Town and Durban. Cradle of Humankind, Archaeological findings suggest that various hominid species existed in South Africa about 2.5 million years ago, and modern humans inhabited the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nervous System
In biology, the nervous system is the complex system, highly complex part of an animal that coordinates its behavior, actions and sense, sensory information by transmitting action potential, signals to and from different parts of its body. The nervous system detects environmental changes that impact the body, then works in tandem with the endocrine system to respond to such events. Nervous tissue first arose in Ediacara biota, wormlike organisms about 550 to 600 million years ago. In Vertebrate, vertebrates, it consists of two main parts, the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS consists of the brain and spinal cord. The PNS consists mainly of nerves, which are enclosed bundles of the long fibers, or axons, that connect the CNS to every other part of the body. Nerves that transmit signals from the brain are called motor nerves (efferent), while those nerves that transmit information from the body to the CNS are called sensory nerves (aff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muscular System
The muscular system is an organ (anatomy), organ system consisting of skeletal muscle, skeletal, smooth muscle, smooth, and cardiac muscle, cardiac muscle. It permits movement of the body, maintains posture, and circulates blood throughout the body. The muscular systems in vertebrates are controlled through the nervous system although some muscles (such as the cardiac muscle) can be completely autonomous. Together with the Human skeleton, skeletal system in the human, it forms the musculoskeletal system, which is responsible for the movement of the human body, body. Types There are three distinct types of muscle: skeletal muscle, cardiac muscle, cardiac or heart muscle, and smooth muscle, smooth (non-striated) muscle. Muscles provide strength, balance, posture, movement, and heat for the body to keep warm. There are more than 600 muscles in an adult male human body. A kind of elastic tissue makes up each muscle, which consists of thousands, or tens of thousands, of small musc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
