|
Cardenolide
A cardenolide is a type of steroid. Many plants contain derivatives, collectively known as cardenolides, including many in the form of cardenolide glycosides (cardenolides that contain structural groups derived from sugars). Cardenolide glycosides are often toxic; specifically, they are cardiac arrest, heart-arresting. Cardenolides are toxic to animals through inhibition of the enzyme Na+/K+-ATPase, Na+/K+-ATPase, which is responsible for maintaining the sodium and Potassium in biology, potassium ion gradients across the cell membranes. Etymology The term derives from ''card-'' "heart" (from Greek language, Greek καρδία ''kardiā'') and the suffix , referring to the lactone ring with double bond at C17. Cardenolides are a class of steroids (or aglycones if viewed as cardiac glycoside constituents), and cardenolides are a subtype of this class (see Wikipedia:MeSH D04#MeSH D04.808.155 --- cardenolides, MeSH D codes list). Structure Cardenolides are C(23)-steroids with methyl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monarch Butterfly
The monarch butterfly or simply monarch (''Danaus plexippus'') is a milkweed butterfly (subfamily Danainae) in the family Nymphalidae. Other common names, depending on region, include milkweed, common tiger, wanderer, and black-veined brown. It is among the most familiar of List of butterflies of North America, North American butterflies and an iconic pollinator, although it is not an especially effective pollinator of milkweeds. Its wings feature an easily recognizable black, orange, and white pattern, with a wingspan of . A Müllerian mimic, the viceroy butterfly, is similar in color and pattern, but is markedly smaller and has an extra black stripe across each hindwing. The eastern North American monarch population is notable for its annual southward late-summer/autumn instinctive Monarch butterfly migration, migration from the northern and central United States and southern Canada to Florida and Mexico. During the fall migration, monarchs cover thousands of miles, with a co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Queen (butterfly)
The queen butterfly (''Danaus gilippus'') is a North and South American butterfly in the family Nymphalidae with a wingspan of . It is orange or brown with black wing borders and small white forewing spots on its Dorsum (biology), dorsal wing surface, and reddish ventral wing surface fairly similar to the dorsal surface. The ventral hindwings have black veins and small white spots in a black border. The male has a black androconial scent patch on its dorsal hindwings. It can be found in meadows, fields, marshes, deserts, and at the edges of forests. This species is possibly a close relative to the similarly colored soldier butterfly (or tropical queen, ''Danaus eresimus, D. eresimus''), in any case, it is not close to the plain tiger (''Danaus chrysippus, D. chrysippus'', African queen) as was long believed. There are seven subspecies. Females lay one egg at a time on larval host plants. Larvae use these plants as a food source, whereas adult butterflies feed mainly on nectar fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Danaus Chrysippus
''Danaus chrysippus'', also known as the plain tiger, African queen, or African monarch, is a medium-sized butterfly widespread in Asia, Australia and Africa. It belongs to the Danainae subfamily of the brush-footed butterfly Family (biology), family Nymphalidae. Danainae primarily consume plants in the genus ''Asclepias'', more commonly called milkweed. Milkweed contains toxic compounds, cardenolides, which are often consumed and stored by many butterflies. Because of their emetic properties, the plain tiger is Palatability, unpalatable to most predators. As a result, its colouration is widely mimicry, mimicked by other species of butterflies. The plain tiger inhabits a wide variety of habitats, although it is less likely to thrive in jungle-like conditions and is most often found in drier, wide-open areas. ''D. chrysippus'' encompasses three main subspecies: ''D. c. alcippus, D. c. chrysippus,'' and ''D. c. orientis.'' These subspecies are found co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiac Glycoside
Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. Their beneficial medical uses include treatments for congestive heart failure and cardiac arrhythmias; however, their relative toxicity prevents them from being widely used. Most commonly found as defensive poisons in several plant genera such as ''Digitalis'' (the foxgloves) and '' Asclepias'' (the milkweeds), these compounds nevertheless have a diverse range of biochemical effects regarding cardiac cell function and have also been suggested for use in cancer treatment. Classification General structure The general structure of a cardiac glycoside consists of a steroid molecule attached to a sugar (glycoside) and an R group. The steroid nucleus consists of four fused rings to which other functional groups such as methyl, hydroxyl, and aldehyde groups can be attached to influence th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strophanthidin
k-Strophanthidin is a cardenolide found in species of the genus ''Strophanthus''. It is the aglycone of k-strophanthin, an analogue of ouabain. k-strophanthin is found in the ripe seeds of Strophanthus kombé and in the lily Convallaria. K-Strophantidin can be differentiated into: * k-Strophanthin-α, h-Strophanthin, Cymarin, Strophanthidin-D-cymarosid (CAS: 508-77-0) * k-Strophanthin-β, k-Strophanthin, Strophosid, Strophanthidin-glucocymarosid (CAS: 560-53-2) * k-Strophanthin-γ,k-Strophanthosid, Strophanthidin-diglucocymarosid (CAS: 33279-57-1) * Convallatoxin or Strophanthidin-L-rhamnosid (CAS: 508-75-8) * Convallosid or Strophanthidin-glucorhamnosid (CAS: 13473-51-3) Strophantidin is a cardiac glycoside which mechanism of action is similar to Digitalis, Ouabain and digitoxin. It specifically inhibits the membrane protein Na+/ K+ ATPase in muscle tissue (heart) which can lead to Ca2+ overload, diastolic dysfunction, arrhythmias and ultimately to heart failure and death. N ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ouabain
Ouabain or (from Somali ''waabaayo'', "arrow poison" through French ''ouabaïo'') also known as g-strophanthin, is a plant derived toxic substance that was traditionally used as an arrow poison in eastern Africa for both hunting and warfare. Ouabain is a cardiac glycoside and, in lower doses, can be used medically to treat hypotension and some arrhythmias. It acts by inhibiting the Na/K-ATPase, also known as the sodium–potassium ion pump. However, adaptations to the alpha-subunit of the -ATPase via amino acid substitutions, have been observed in certain species, namely some herbivore insect species, that have resulted in toxin resistance. It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities. Sources Ouabain can be found in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neoconvalloside
Neoconvalloside is a cardenolide glycoside extracted from ''Convallaria majalis Lily of the valley (''Convallaria majalis'' ), sometimes written lily-of-the-valley, is a woodland flowering plant with sweetly scented, pendent, bell-shaped white flowers borne in sprays in spring. It is native throughout the cool temperate No ...''. References Cardenolides Aldehydes Rhamnosides {{steroid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Digitoxigenin
Digitoxigenin, a cardenolide, is the aglycone of digitoxin. Digitoxigenin can be used to prepare actodigin. In Lednicer's book on steroids, it is made from deoxycholic acid Deoxycholic acid is a bile acid. Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The two primary bile acids secreted by the liver are cholic acid and chenodeoxycholic acid. Bacteria m .... References Cardenolides Diols {{steroid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Digitoxin
Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting. Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in patients with poor or erratic kidney function. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective. Medical uses Digitoxin is used for the treatment of heart failure, especially in people with impaired kidney function. It is also used to treat certain kinds of heart arrhythmia, such as atrial fibrillation. Contraindications Contraindications include * problems with the heart rhythm, such as severe bradycardia (slow heartbeat), ventricular tachycardia (fast heartbeat caused ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroid
A steroid is an organic compound with four fused compound, fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signal transduction, signaling molecules. Examples include the lipid cholesterol, sex hormones estradiol and testosterone, anabolic steroids, and the anti-inflammatory corticosteroid drug dexamethasone. Hundreds of steroids are found in Fungus, fungi, plants, and animals. All steroids are manufactured in cells from a sterols, sterol: Cholesterol, cholesterol (animals), lanosterol (opisthokonts), or cycloartenol (plants). All three of these molecules are produced via Cyclic compound, cyclization of the triterpene squalene. Structure The steroid nucleus (parent structure, core structure) is called gonane (cyclopentanoperhydrophenanthrene). It is typically composed of seventeen carbon atoms, bonded in fou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufadienolide
Bufadienolide is a chemical compound with steroid structure. Its derivatives are collectively known as bufadienolides, including many in the form of bufadienolide glycosides (bufadienolides that contain structural groups derived from sugars). These are a type of cardiac glycoside, the other being the cardenolide glycosides. Both bufadienolides and their glycosides are toxic; specifically, they can cause an atrioventricular block, bradycardia (slow heartbeat), ventricular tachycardia (a type of rapid heartbeat), and possibly lethal cardiac arrest. Etymology The term derives from the toad genus '' Bufo'' that contains bufadienolide glycosides, the suffix ''-adien-'' that refers to the two double bonds in the lactone ring, and the ending ''-olide'' that denotes the lactone structure. Consequently, related structures with only one double bond are called ''bufenolides'', and the saturated equivalent is ''bufanolide''. Classification According to MeSH, bufadienolides and bufan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
