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DOTFM-NDEPA
DOTFM-NDEPA is a chemical compound of the phenethylamine, DOx, and NDEPA families. It is the ''N''-(''N'',''N''-diethylpropylamide) (NDEPA) derivative of the psychedelic drug DOTFM. The drug can also be thought of as a derivative of DOTFM with an LSD-like ''N'',''N''-diethylamide moiety. A quantitative structure–activity relationship (QSAR) predicted that DOTFM-NDEPA would bind with high affinity to the serotonin 5-HT2A receptor. Its predicted affinity (Ki) was 22nM. DOTFM-NDEPA was first described in the scientific literature by 1999. See also * Substituted methoxyphenethylamine * Partial lysergamide * DOB-NDEPA * DOI-NDEPA * 25D-NM-NDEAOP * ''N''-DEAOP-NMPEA * DEMPDHPCA-2C-D DEMPDHPCA-2C-D is a possible serotonergic psychedelic of the phenethylamine and 2C families. It is a cyclized phenethylamine and a partial or simplified lysergamide. More specifically, the compound is a derivative of 2C-D in which the β positi ... References Amides Diethylamino compou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Ergolines
Partial or simplified ergolines and lysergamides are analogues of ergolines and lysergamides like LSD in which one or more atoms or bonds, for instance within the ergoline ring system, have been removed. Additional substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded tryptamine and phenethylamine moieties within its structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ... and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DOx (psychedelics)
4-Substituted-2,5-dimethoxyamphetamines (DO''x'') is a chemical class of substituted amphetamine derivatives featuring methoxy groups at the 2- and 5- positions of the phenyl ring, and a substituent such as alkyl or halogen at the 4- position of the phenyl ring. They are 4-substituted derivatives of 2,5-dimethoxyamphetamine (2,5-DMA, DOH) and are structurally related to the naturally occurring phenethylamine psychedelic mescaline. The most well-known DOx drugs are DOM, DOI, DOB, DOET, and DOC. DOI is widely used in scientific research. DOM has been used as a recreational drug, while DOET was an experimental pharmaceutical drug. Most compounds of this class are potent and long-lasting psychedelic drugs, and act as selective 5-HT2A, 5-HT2B, and 5-HT2C receptor agonists. A few bulkier derivatives such as DOAM have similarly high affinity for 5-HT2 receptors but have reduced activational efficacy and do not produce psychedelic effects. DOI has been found to have ext ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NDEPA
Partial or simplified ergolines and lysergamides are analogues of ergolines and lysergamides like LSD in which one or more atoms or bonds, for instance within the ergoline ring system, have been removed. Additional substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded tryptamine and phenethylamine moieties within its structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5, are serotonin 5-HT2A receptor agonists and have psychedelic-like and/or psychoplastogenic effects. Some, like 8-OH-DPAT and LY-178210, are selective serotonin 5-HT1A receptor agonists. Others, like rotigotine, nolomirole, and RU-28251, are dopamine D2-like receptor agonists. Partial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25D-NM-NDEAOP
25D-NM-NDEAOP, or 25D-NM-NDEPA, is a chemical compound of the substituted phenethylamine, phenethylamine and 2C (psychedelics), 2C families. It is a partial lysergamide, simplified or partial lysergamide and is a chemical derivative, derivative of 2C-D with a lysergic acid diethylamide (LSD)-like ''N''-(3-diethylamino-3-oxopropyl)- chemical substituent, substitution. The compound was assessed and found to inhibit prolactin secretion in rat pituitary glands ''in vitro'' at high concentrations, suggesting that it may possess weak dopamine receptor agonist activity. However, it was subsequently assessed in rats ''in vivo'' and, in contrast to LSD, was found to not significantly inhibit prolactin secretion. Other possible activities of 25D-NM-NDEAOP, such as serotonin receptor interactions and associated effects, were not evaluated or reported. 25D-NDEAOP was first described in the scientific literature in 1974. The compound is a "PEA-NDEPA" and is similar in structure to other PEA- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Lysergamide
Partial or simplified ergolines and lysergamides are analogues of ergolines and lysergamides like LSD in which one or more atoms or bonds, for instance within the ergoline ring system, have been removed. Additional substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded tryptamine and phenethylamine moieties within its structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5, are serotonin 5-HT2A receptor agonists and have psychedelic-like and/or psychoplastogenic effects. Some, like 8-OH-DPAT and LY-178210, are selective serotonin 5-HT1A receptor agonists. Others, like rotigotine, nolomirole, and RU-28251, are dopamine D2-like receptor agonists. Par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Methoxyphenethylamine
Methoxyphenethylamines (MPEAs), as well as methoxyamphetamines (MAs) in the case of the amphetamine (α-methylphenethylamine) homologues, are substituted phenethylamines with one or more methoxy groups. In some cases, one or more of the methoxy groups may also be extended to form other alkoxy and related groups such as ethoxy or propoxy. Methoxyphenethylamines may have additional substitutions as well. Many methoxyphenethylamines that have multiple methoxy groups in the 2- through 5-positions of the phenyl ring, for instance mescaline, 2C-B, TMA, DOM, and 25I-NBOMe, are serotonin 5-HT2A receptor agonists and serotonergic psychedelics. Other methoxyphenethylamines, particularly monomethoxyamphetamines like ''para''-methoxyamphetamine (PMA), are monoamine releasing agents of serotonin, norepinephrine, and/or dopamine, with stimulant and/or entactogen-related effects. Compounds closely related to methoxyphenethylamines include methylenedioxyphenethylamines (MDxx) like M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-DEAOP-NMPEA
''N''-(3-Diethylamino-3-oxopropyl)-''N''-methyltryptamine (''N''-DEAOP-NMT) is a tryptamine derivative and a "partial" or simplified ergoline which is closely related to the highly potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is the analogue of LSD in which two of LSD's carbon atoms in the ergoline ring, those at positions 9 and 10, have been removed. This in turn renders the ''N''-DEAOP-NMT molecule flexible and makes it a non-rigid tryptamine rather than an ergoline. The compound is pharmacologically active, as are a number of its analogues and derivatives, with activities of the compounds including serotonin 5-HT2A receptor agonism and LSD- or hallucinogen-like effects. Pharmacology ''N''-DEAOP-NMT has been found to produce quantifiable oxytocic effects in animals. However, in contrast to other lysergamides such as lysergic acid and ergonovine (ergometrine), ''N''-DEAOP-NMT was said to not possess significant oxytocic activity relative to clini ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DOI-NDEPA
DOI-NDEPA is a chemical compound of the phenethylamine, DOx, and NDEPA families. It is the ''N''-(''N'',''N''-diethylpropylamide) (NDEPA) derivative of the psychedelic drug DOI. The drug can also be thought of as a derivative of DOI with an LSD-like ''N'',''N''-diethylamide moiety. A quantitative structure–activity relationship (QSAR) predicted that DOI-NDEPA would bind with high affinity to the serotonin 5-HT2A receptor. Its predicted affinity (Ki) was 3.2nM. DOI-NDEPA was first described in the scientific literature by 1999. See also * Substituted methoxyphenethylamine * Partial lysergamide * DOB-NDEPA * DOTFM-NDEPA * 25D-NM-NDEAOP * ''N''-DEAOP-NMPEA * DEMPDHPCA-2C-D DEMPDHPCA-2C-D is a possible serotonergic psychedelic of the phenethylamine and 2C families. It is a cyclized phenethylamine and a partial or simplified lysergamide. More specifically, the compound is a derivative of 2C-D in which the β positi ... References Amides Iodobenzene derivatives Di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DOB-NDEPA
DOB-NDEPA is a chemical compound of the phenethylamine, DOx, and NDEPA families. It is the ''N''-(''N'',''N''-diethylpropylamide) (NDEPA) derivative of the psychedelic drug DOB. The drug can also be thought of as a derivative of DOB with an LSD-like ''N'',''N''-diethylamide moiety. A quantitative structure–activity relationship (QSAR) predicted that DOB-NDEPA would bind with high affinity to the serotonin 5-HT2A receptor. Its predicted affinity (Ki) was 4.6nM. DOB-NDEPA was first described in the scientific literature by 1999. See also * Substituted methoxyphenethylamine * Partial lysergamide * DOI-NDEPA * DOTFM-NDEPA * 25D-NM-NDEAOP * ''N''-DEAOP-NMPEA * DEMPDHPCA-2C-D DEMPDHPCA-2C-D is a possible serotonergic psychedelic of the phenethylamine and 2C families. It is a cyclized phenethylamine and a partial or simplified lysergamide. More specifically, the compound is a derivative of 2C-D in which the β positi ... References Amides Bromobenzene derivatives Die ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serotonin
Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, memory, and physiological processes such as vomiting and vasoconstriction. In the CNS, serotonin regulates mood, appetite, and sleep. Most of the body's serotonin—about 90%—is synthesized in the gastrointestinal tract by enterochromaffin cells, where it regulates intestinal movements. It is also produced in smaller amounts in the brainstem's raphe nuclei, the skin's Merkel cells, pulmonary neuroendocrine cells, and taste receptor cells of the tongue. Once secreted, serotonin is taken up by platelets in the blood, which release it during clotting to promote vasoconstriction and platelet aggregation. Around 8% of the body's serotonin is stored in platelets, and 1–2% is found in the CNS. Serotonin acts as both a vasoconstrictor and vas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amides
In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula , where R, R', and R″ represent any group, typically organyl groups or hydrogen atoms. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, as in asparagine and glutamine. It can be viewed as a derivative of a carboxylic acid () with the hydroxyl group () replaced by an amino group (); or, equivalently, an acyl (alkanoyl) group () joined to an amino group. Common amides are formamide (), acetamide (), benzamide (), and dimethylformamide (). Some uncommon examples of amides are ''N''-chloroacetamide () and chloroformamide (). Amides are qualified as primary, secondary, and tertiary according to the number of acyl groups bounded to the nitrogen atom. Nomenclature The core of amides is called the amide group (specifically, carboxamide group). In the usual no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
