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DOB-NBOMe
DOB-NBOMe, or NBOMe-DOB, also known as ''N''-(2-methoxybenzyl)-4-bromo-2,5-dimethoxyamphetamine, is a serotonin 5-HT2A receptor agonist and possible psychedelic drug of the phenethylamine, DOx, and 25-NB (NBOMe) families. It is the ''N''-(2-methoxybenzyl) derivative of DOB and the amphetamine (i.e., α-methyl) analogue of 25B-NBOMe. Pharmacology The drug is a potent serotonin 5-HT2A receptor partial agonist, with an of 7.94nM and an of 20% in the employed assay. As an agonist of the serotonin 5-HT2A receptor, DOB-NBOMe had about the same potency as DOB but had greatly reduced efficacy in comparison ''in vitro'' (with DOB having an of 10.2nM and an of 71%). Compared to 25B-NBOMe, the corresponding NBOMe analogue of 2C-B, DOB-NBOMe had about 30-fold lower potency as a serotonin 5-HT2A receptor agonist and about half the activational efficacy. Whereas the potency of 2Cs can be dramatically increased by ''N''-(2-methoxybenzyl) substitution, this has not been the case with the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DOx (psychedelics)
4-Substituted-2,5-dimethoxyamphetamines (DO''x'') is a chemical class of substituted amphetamine derivatives featuring methoxy groups at the 2- and 5- positions of the phenyl ring, and a substituent such as alkyl or halogen at the 4- position of the phenyl ring. They are 4-substituted derivatives of 2,5-dimethoxyamphetamine (2,5-DMA, DOH) and are structurally related to the naturally occurring phenethylamine psychedelic mescaline. The most well-known DOx drugs are DOM, DOI, DOB, DOET, and DOC. DOI is widely used in scientific research. DOM has been used as a recreational drug, while DOET was an experimental pharmaceutical drug. Most compounds of this class are potent and long-lasting psychedelic drugs, and act as selective 5-HT2A, 5-HT2B, and 5-HT2C receptor agonists. A few bulkier derivatives such as DOAM have similarly high affinity for 5-HT2 receptors but have reduced activational efficacy and do not produce psychedelic effects. DOI has been found to have ext ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25-NB (psychedelics)
The 25-NB (25''x''-NB''x'') series, or NBOMe series, also known as the ''N''-benzylphenethylamines, is a family of serotonergic psychedelics. They are substituted phenethylamines and were derived from the 2C (psychedelics), 2C family. The most commonly encountered NBOMe drugs are 25I-NBOMe, 25B-NBOMe, and 25C-NBOMe. The NBOMe drugs act as selective agonists of the serotonin 5-HT2 receptor, 5-HT2 receptors. The 25-NB family is unique relative to other classes of psychedelics in that they are, generally speaking, extremely potency (pharmacology), potent and quite binding selectivity, selective for the 5-HT2 receptors. Use of NBOMe series drugs has caused many deaths and hospitalisations since the drugs popularisation in the 2010s. This is primarily due to their high potency, unpredictable pharmacokinetics, and sellers passing off the compounds in the series as Lysergic acid diethylamide, LSD. Use The 25-NB drugs are inactive oral administration, orally and instead are typically u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
