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Cyclacel
Cyclacel Pharmaceuticals Inc. is a biotechnology firm based in Dundee, Scotland, and Short Hills, New Jersey, developing cancer drugs and treatments. Cyclacel was founded in 1996 by David Lane, Merlin Ventures and Cancer Research Campaign Technology with the University of Dundee and the University of Glasgow. Company overview Cyclacel Pharmaceuticals, Inc. is a biopharmaceutical company developing oral therapies that target the various phases of cell cycle control for the treatment of cancer and other serious diseases. Sir David Lane, a recognized leader in the field of tumor suppressor biology, who discovered the p53 protein, founded the company in 1996. In 1999, Cyclacel Pharmaceuticals was joined by David Glover, a recognized leader in the mechanism of mitosis or cell division, who discovered, among other cell cycle targets, the mitotic kinases, Polo and Aurora, enzymes that act in the mitosis phase of the cell cycle. Three product candidates are currently in clinical devel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sapacitabine
Sapacitabine is a Chemotherapy, chemotherapeutic drug developed by US biotechnology firm Cyclacel currently undergoing clinical trials against leukemia. Sapacitabine is an orally available nucleoside analogue, nucleoside analog prodrug of 2′-C-cyano-2′-deoxy-1-β-''D''-arabino-pentofuranosyl-cytosine (CNDAC) that acts through a dual mechanism. CNDAC lasts longer in the bloodstream by being metabolized from sapacitibine than it would do so by being directly administered. The compound interferes with DNA synthesis by causing single-strand DNA breaks due to CNDAC being incorporated into DNA during replication or repair, then inducing arrest of the cell division cycle at G2 phase. Both sapacitabine and its major metabolite, CNDAC, have demonstrated potent anti-tumor activity in both blood and solid tumors in Preclinical development, preclinical studies. In a liver metastatic mouse model, sapacitabine was shown to be superior to gemcitabine or 5-FU, two widely used nucleoside a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seliciclib
Seliciclib (roscovitine or CYC202) is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9, which alter the growth phase or state within the cell cycle of treated cells. Seliciclib is being developed by Cyclacel. This is a phase II, dose ranging, multicenter, randomized, double-blind, placebo-controlled study. The aim of this study is to assess the safety of increasing doses of roscovitine administered orally for 4 cycles of 4 consecutive days (treatment "on") separated by a 3 days treatment free period (treatment "off") in adult CF subjects with Cystic Fibrosis carrying 2 Cystic Fibrosis causing mutations with at least one F508del-CFTR mutation and chronically infected with Pseudomonas aeruginosa. This study involved 36 Cystic Fibrosis patients: 24 treated and 12 controls. Seliciclib is being researched for the treatment of non-small cell lun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berkeley Heights, New Jersey
Berkeley Heights is a Township (New Jersey), township in Union County, New Jersey, Union County, in the U.S. state of New Jersey. Located on a ridge in North Jersey, northern-central Jersey, central New Jersey, Berkeley Heights is a commuter town of New York City in the New York metropolitan area, nestled within the Raritan River, Raritan Valley region and also bordering both Morris County, New Jersey, Morris and Somerset County, New Jersey, Somerset counties in the Passaic River, Passaic Valley region. As of the 2020 United States census, the township's population was 13,285, an increase of 102 (+0.8%) from the 2010 United States census, 2010 census count of 13,183, which in turn reflected a decline of 224 (−1.7%) from the 13,407 counted in the 2000 United States census, 2000 census. The township was originally incorporated as New Providence Township by the New Jersey Legislature on November 8, 1809, from portions of Springfield Township, Union County, New Jersey, Springfield ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reverse Merger
A reverse takeover (RTO), reverse merger, or reverse IPO is the acquisition of a public company by a private company so that the private company can bypass the lengthy and complex process of going public. Sometimes, conversely, the public company is bought by the private company through an asset swap and share issue. The transaction typically requires reorganization of capitalization of the acquiring company. Process In a reverse takeover, shareholders of a private company purchase control of a public shell company/ SPAC, and then merge it with the private company. The publicly traded corporation is called a "shell," since all that exists of the original company is its organizational structure. The private company shareholders receive a substantial majority of the shares of the public company and control of its board of directors. The transaction can be accomplished within weeks. The transaction involves the private and shell company exchanging information on each other, negot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmaceutical Companies Established In 1996
Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and relies on the science of pharmacology for continual advancement and on pharmacy for appropriate management. Drugs are classified in many ways. One of the key divisions is by level of control, which distinguishes prescription drugs (those that a pharmacist dispenses only on the medical prescription) from over-the-counter drugs (those that consumers can order for themselves). Medicines may be classified by mode of action, route of administration, biological system affected, or therapeutic effects. The World Health Organization keeps a list of essential medicines. Drug discovery and drug development are complex and expensive endeavors undertaken by pharmaceutical companies, academic scientists, and governments. As a result ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
