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CompoZr
The CompoZr Zinc finger nuclease (ZFN) platform is a technology developed by Sigma-Aldrich Sigma-Aldrich (formally MilliporeSigma) is an American chemical, life science, and biotechnology company owned by the multinational chemical conglomerate Merck Group. Sigma-Aldrich was created in 1975 by the merger of Sigma Chemical Company and ... that allows researchers to target and manipulate the genome of living cells thereby creating cell lines or entire organisms with permanent and heritable gene deletions, insertions, or modifications. The technology was released in September 2008. In December 2008, CompoZr ZFN Technology ranked third in The Scientist Magazine's Top Ten Innovations of 2008. In July 2009, the first genetically modified mammal was created through the use of CompoZr ZFN Technology. References External linksCompoZr Homepage [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zinc Finger Nuclease
Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a nuclease, DNA-cleavage domain. Zinc finger domains can be engineered to target specific desired DNA sequences and this enables zinc-finger nucleases to target unique sequences within complex genomes. By taking advantage of endogenous DNA repair machinery, these reagents can be used to precisely alter the genomes of higher organisms. Alongside CRISPR, CRISPR/Cas9 and TALEN, ZFN is a prominent tool in the field of genome editing. It was initially created by researcher Srinivasan Chandrasegaran. Domains DNA-binding domain The DNA-binding domains of individual ZFNs typically contain between three and six individual zinc finger repeats and can each recognize between 9 and 18 basepairs. If the zinc finger domains perfectly recognize a 3 basepair DNA sequence, they can generate a 3-finger array that can recognize a 9 basepair target site. Other procedures can u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sigma-Aldrich
Sigma-Aldrich (formally MilliporeSigma) is an American chemical, life science, and biotechnology company owned by the multinational chemical conglomerate Merck Group. Sigma-Aldrich was created in 1975 by the merger of Sigma Chemical Company and Aldrich Chemical Company. It grew through various acquisitions until it had over 9,600 employees and was listed on the Fortune 1000. The company has two United States headquarters, in St. Louis and Burlington, MA and has operations in approximately 40 countries. In 2015, the multinational chemical conglomerate Merck Group acquired Sigma-Aldrich for $17 billion. The company is currently a part of Merck's life science business and in combination with Merck's earlier acquired Millipore Corporation, Millipore, operates as MilliporeSigma. It is headquartered in Burlington, Massachusetts, United States. History Sigma Chemical Company of St. Louis and Aldrich Chemical Company of Milwaukee were both American specialty chemical companies when they ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Scientist (magazine)
''The Scientist'' is a professional magazine intended for life scientists. ''The Scientist'' covers recently published research papers, current research, techniques, and other columns and reports of interest to its readers. The magazine is published monthly and is available in print and digital formats. Overview The main purpose of the magazine is to provide print and online coverage of the latest developments in life sciences research, technology, careers, and business. Subject matters covered by the magazine include groundbreaking research, industry innovations, careers, financial topics, the economics of science, scientific ethics, profiles of scientists, lab tools, scientific publishing, techniques, product spotlight, and guides. History ''The Scientist'' was founded in 1986 by American businessman Eugene Garfield as part of his academic publishing service ''Institute for Scientific Information.'' The publishing house was sold two years later to ''JPT Publishing'', but Eug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Engineered Proteins
Engineering is the practice of using natural science, mathematics, and the engineering design process to solve problems within technology, increase efficiency and productivity, and improve systems. Modern engineering comprises many subfields which include designing and improving infrastructure, machinery, vehicles, electronics, materials, and energy systems. The discipline of engineering encompasses a broad range of more specialized fields of engineering, each with a more specific emphasis for applications of mathematics and science. See glossary of engineering. The word ''engineering'' is derived from the Latin . Definition The American Engineers' Council for Professional Development (the predecessor of the Accreditation Board for Engineering and Technology aka ABET) has defined "engineering" as: History Engineering has existed since ancient times, when humans devised inventions such as the wedge, lever, wheel and pulley, etc. The term ''engineering'' is derived f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
