The CompoZr
Zinc finger nuclease
Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a nuclease, DNA-cleavage domain. Zinc finger domains can be engineered to target specific desired DNA sequences and this enab ...
(ZFN) platform is a technology developed by
Sigma-Aldrich
Sigma-Aldrich (formally MilliporeSigma) is an American chemical, life science, and biotechnology company owned by the multinational chemical conglomerate Merck Group.
Sigma-Aldrich was created in 1975 by the merger of Sigma Chemical Company and ...
that allows researchers to target and manipulate the genome of living cells thereby creating cell lines or entire organisms with permanent and heritable gene deletions, insertions, or modifications.
The technology was released in September 2008. In December 2008, CompoZr ZFN Technology ranked third in
The Scientist Magazine's Top Ten Innovations of 2008.
In July 2009, the first genetically modified mammal was created through the use of CompoZr ZFN Technology.
References
External links
CompoZr HomepageCompoZr Publications
Engineered proteins
Zinc proteins
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