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Clinic For Special Children
The Clinic for Special Children (CSC) is a primary pediatric care and gene research clinic located in Strasburg, Pennsylvania. The facility specializes in genetic problems of the plain sects, such as the Amish and Old Order Mennonites. It was founded in 1989. The most common genetic disorders treated by the Clinic are glutaric acidemia type I (GA1), which is common in the Amish population and maple syrup urine disease (MSUD), which has a high prevalence in the Old Order Mennonites. Establishment The Clinic for Special Children was founded by the Plain community with Dr. D. Holmes Morton and his wife, Caroline in 1989. The clinic building was raised by the Plain community and completed in 1990 while an addition was added in 2000. In addition to patient care facilities, the Clinic also houses its own laboratories, providing rapid biochemical and molecular A molecule is a group of two or more atoms held together by attractive forces known as chemical bonds; depending on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinic For Special Children Logo 2018
A clinic (or outpatient clinic or ambulatory care clinic) is a health facility that is primarily focused on the care of outpatients. Clinics can be privately operated or publicly managed and funded. They typically cover the primary care needs of populations in local communities, in contrast to larger hospitals which offer more specialised treatments and admit inpatients for overnight stays. Most commonly, the English word clinic refers to a general practice, run by one or more general practitioners offering small therapeutic treatments, but it can also mean a specialist clinic. Some clinics retain the name "clinic" even while growing into institutions as large as major hospitals or becoming associated with a hospital or medical school. Etymology The word ''clinic'' derives from Ancient Greek ''klinein'' meaning to slope, lean or recline. Hence ''klinē'' is a couch or bed and ''klinikos'' is a physician who visits his patients in their beds. In Latin, this became '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Old Order Mennonites
Old Order Mennonites (Pennsylvania German: ) form a branch of the Mennonite tradition. Old Order are those Mennonite groups of Swiss German and south German heritage who practice a lifestyle without some elements of modern technology, who still drive a horse and buggy rather than cars, wear very conservative and modest dress plainly and who have retained the old forms of worship, baptism and communion. All Old Order Mennonites reject certain technologies (e.g., radio, television, Internet), but the extent of this rejection depends on the individual group. Old Order groups generally place great emphasis on a disciplined community instead of the individual's personal faith beliefs. The Pennsylvania German language is spoken and vigorous among all horse-and-buggy groups except the Virginia Old Order Mennonites, who lost their original language before becoming Old Order. There is no overall church or conference to unite all the different groups of Old Order Mennonites. In 2008–2009 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemical Genetics
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Rosa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barn Raising
A barn raising, also historically called a raising bee or rearing in the U.K., is a collective action of a community, in which a barn for one of the members is built or rebuilt collectively by members of the community. Barn raising was particularly common in 18th- and 19th-century rural North America. A barn was a necessary structure for any farmer, for example for storage of cereals and hay and keeping of animals. Yet a barn was also a large and costly structure, the assembly of which required more labor than a typical family could provide. Barn raising addressed the need by enlisting members of the community, unpaid, to assist in the building of their neighbors' barns. Because each member could ask others for help, reciprocation could eventually reasonably be presumed for each participant if the need were to arise. The tradition of "barn raising" continues, more or less unchanged, in some Amish and Old Order Mennonite communities, particularly in Ohio, Indiana, Pennsylvania, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maple Syrup Urine Disease
Maple syrup urine disease (MSUD) is an autosomal recessive metabolic disorder affecting branched-chain amino acids. It is one type of organic acidemia. The condition gets its name from the distinctive sweet odor of affected infants' urine and earwax, particularly prior to diagnosis and during times of acute illness. Signs and symptoms The disease is named for the presence of sweet-smelling urine, similar to maple syrup, when the person goes into metabolic crisis. The smell is also detected in ear wax of an affected individual during metabolic crisis. In populations to whom maple syrup is unfamiliar, the aroma can be likened to fenugreek, and fenugreek ingestion may impart the aroma to urine. Symptoms of MSUD varies between patients and is greatly related to the amount of residual enzyme activity. Classic MSUD Infants with classic MSUD will display subtle symptoms within the first 24–48 hours. Subtle symptoms include poor feeding, either bottle or breast, lethargy, and irritab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glutaric Acidemia Type I
Glutaric acidemia type 1 (GA1) is an inherited disorder in which the body is unable to completely break down the amino acids lysine, hydroxylysine and tryptophan. Excessive levels of their intermediate breakdown products (glutaric acid, glutaryl-CoA, 3-hydroxyglutaric acid, glutaconic acid) can accumulate and cause damage to the brain (and also other organs), but particularly the basal ganglia, which are regions that help regulate movement. GA1 causes secondary carnitine deficiency, as glutaric acid, like other organic acids, is detoxified by carnitine. Mental retardation may occur. GA1 is an autosomal recessive disorder caused by deficiency of the enzyme glutaryl-CoA dehydrogenase (GCDH), encoded by the ''GCDH'' gene. Signs and symptoms The severity of glutaric acidemia type 1 varies widely; some individuals are only mildly affected, while others suffer severe problems. GA1 can be defined as two clinical entities: GA-1 diagnosed at birth or pre-birth and managed through die ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Washington Post
''The Washington Post'' (also known as the ''Post'' and, informally, ''WaPo'') is an American daily newspaper published in Washington, D.C. It is the most widely circulated newspaper within the Washington metropolitan area and has a large national audience. Daily broadsheet editions are printed for D.C., Maryland, and Virginia. The ''Post'' was founded in 1877. In its early years, it went through several owners and struggled both financially and editorially. Financier Eugene Meyer purchased it out of bankruptcy in 1933 and revived its health and reputation, work continued by his successors Katharine and Phil Graham (Meyer's daughter and son-in-law), who bought out several rival publications. The ''Post'' 1971 printing of the Pentagon Papers helped spur opposition to the Vietnam War. Subsequently, in the best-known episode in the newspaper's history, reporters Bob Woodward and Carl Bernstein led the American press's investigation into what became known as the Waterga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The New York Times
''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid digital subscribers. It also is a producer of popular podcasts such as '' The Daily''. Founded in 1851 by Henry Jarvis Raymond and George Jones, it was initially published by Raymond, Jones & Company. The ''Times'' has won 132 Pulitzer Prizes, the most of any newspaper, and has long been regarded as a national "newspaper of record". For print it is ranked 18th in the world by circulation and 3rd in the U.S. The paper is owned by the New York Times Company, which is publicly traded. It has been governed by the Sulzberger family since 1896, through a dual-class share structure after its shares became publicly traded. A. G. Sulzberger, the paper's publisher and the company's chairman, is the fifth generation of the family to head the p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amish
The Amish (; pdc, Amisch; german: link=no, Amische), formally the Old Order Amish, are a group of traditionalist Anabaptist Christian church fellowships with Swiss German and Alsatian origins. They are closely related to Mennonite churches, another Anabaptist denomination. The Amish are known for simple living, plain dress, Christian pacifism, and slowness to adopt many conveniences of modern technology, with a view neither to interrupt family time, nor replace face-to-face conversations whenever possible, and a view to maintain self-sufficiency. The Amish value rural life, manual labor, humility and '' Gelassenheit'' (submission to God's will). The history of the Amish church began with a schism in Switzerland within a group of Swiss and Alsatian Mennonite Anabaptists in 1693 led by Jakob Ammann. Those who followed Ammann became known as Amish. In the second half of the 19th century, the Amish divided into Old Order Amish and Amish Mennonites; the latter do not abstain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Health Care
Health care or healthcare is the improvement of health via the prevention, diagnosis, treatment, amelioration or cure of disease, illness, injury, and other physical and mental impairments in people. Health care is delivered by health professionals and allied health fields. Medicine, dentistry, pharmacy, midwifery, nursing, optometry, audiology, psychology, occupational therapy, physical therapy, athletic training, and other health professions all constitute health care. It includes work done in providing primary care, secondary care, and tertiary care, as well as in public health. Access to health care may vary across countries, communities, and individuals, influenced by social and economic conditions as well as health policies. Providing health care services means "the timely use of personal health services to achieve the best possible health outcomes". Factors to consider in terms of health care access include financial limitations (such as insurance cov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plain Sects
Plain people are Christian groups characterized by separation from the world and by simple living, including plain dressing in modest clothing (including the headcovering for women). Many Plain people have an Anabaptist background. These denominations are largely of German, Swiss German and Dutch ancestry, though people of diverse backgrounds have been incorporated into them. Conservative Friends are traditional Quakers who are also considered plain people; they come from a variety of different ethnic backgrounds. Origins Anabaptists The Mennonite movement was a reform movement of Anabaptist origins begun by Swiss Brethren and soon thereafter finding greater cohesion based on the teachings of Menno Simons 1496–1561, and the 1632 Dordrecht Confession of Faith. The Amish movement was a reform movement within the Mennonite movement, based on the teachings of Jacob Ammann, who perceived a lack of discipline within the Mennonite movement by those trying to avoid persecution. Amm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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