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Carole LaBonne
Carole LaBonne is a Developmental and Stem Cell Biologist at Northwestern University. She is the Erastus Otis Haven Professor of Molecular Biosciences and president of the Society for Developmental Biology. Education and early career LaBonne received her bachelor's degree from the University of Rochester, doing research with Sayeeda Zain on the molecular basis of Alzheimer's disease. Inspired by the work of famed embryologist and Rochester emeritus professor Johannes Holtfreter, LaBonne pursued doctoral work at Harvard University studying germ layer formation using ''Xenopus'' as a model. As a National Science Foundation pre-doctoral Fellow working with Malcolm Whitman, LaBonne characterized the role of FGF signaling in formation of the mesendoderm. During her doctoral study, LaBonne discovered that activin-mediated mesoderm induction required FGF signaling and elucidated the role of RAS-Map Kinase signaling in this process. Following her graduate work, LaBonne pursued post-d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Rochester
The University of Rochester is a private university, private research university in Rochester, New York, United States. It was founded in 1850 and moved into its current campus, next to the Genesee River in 1930. With approximately 30,000 full-time employees, the university is the largest private employer in Upstate New York and the seventh-largest in all of New York (state), New York State. With over 12,000 students, the university offers 160 undergraduate and 30 graduate programs across seven schools spread throughout five campuses. The University of Rochester College of Arts Sciences and Engineering, College of Arts, Sciences, and Engineering is the largest school, and it includes the School of Engineering and Applied Sciences. The Eastman School of Music, founded by and named after George Eastman, is located in Downtown Rochester. The university is also home to Rochester's Laboratory for Laser Energetics, a national laboratory supported by the United States Department of E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SNAI2
Zinc finger protein SNAI2 (also called SLUG) is a transcription factor that in humans is encoded by the ''SNAI2'' gene. It promotes epithelial to mesenchymal transition, differentiation (e.g. in gastrulation), and migration of cells. Function This gene encodes a member of the Snail superfamily of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. It regulates differentiation and migration of neural crest cells along with other genes (e.g. FOXD3, SOX9 and SOX10, BMPs) in embryonic life. Mutations in this gene may be associated with sporadic cases of neural tube defects. SNAI2 downregulates expression of E-cadherin in premigratory neural crest cells; thus, SNAI2 induces tightly bound epithelial cells to break into a loose mesenchym ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Society For Developmental Biology
The Society for Developmental Biology (SDB), originally the Society for the Study of Development and Growth, is an organization for scientists and professionals around the world whose research is focused on the study of the developmental biology, embryology, and related disciplines. History The "Society for the Study of Development and Growth" (SDB) was founded in 1939. In August 1939, the SDB held its first conference, a symposium on Developmental and Growth, in a small village schoolhouse in North Truro, Massachusetts. In 1965, it was renamed the "Society for Developmental Biology" to reflect the SDB's advocacy of developmental biology. Mission The Society for Developmental Biology's mission is to employ, "... an inclusive philosophy to further the study of developmental biology and related disciplines; to foster, support, and provide a forum for all investigators in these fields; to educate non-specialists, educators, the general public, and policymakers about developmental ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FASEB
The Federation of American Societies for Experimental Biology (FASEB), based in Rockville, Maryland, is a non-profit organization of scientific societies in the United States. With a focus on the biological and biomedical sciences, the federation represents scientists in such fields as anatomy, physiology, immunology, biochemistry, molecular biology, toxicology, genetics, and nutrition. Description Founded in 1912, FASEB was established to provide a forum for biological and biomedical researchers enabling them to hold educational meetings, develop publications, and disseminate biological research results. FASEB currently comprises 22 scientific societies. As a federation, FASEB's collective mission is to advance health and well-being by promoting research and education in the biological and biomedical sciences. To advance its mission, FASEB provides a variety of programs and services to its member societies to support their individual members, including advocating for federal fun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Weinberg College Of Arts And Sciences
Northwestern University (NU) is a private research university in Evanston, Illinois, United States. Established in 1851 to serve the historic Northwest Territory, it is the oldest chartered university in Illinois. Chartered by the Illinois General Assembly in 1851, Northwestern was initially affiliated with the Methodist Episcopal Church but later became non-sectarian. By 1900, the university was the third-largest university in the United States, after Michigan and Harvard. Northwestern became a founding member of the Big Ten Conference in 1896 and joined the Association of American Universities in 1917. Northwestern is composed of eleven undergraduate, graduate, and professional schools in the fields of management, law, journalism, engineering, medicine, and others. As of 2024, the university had an endowment of $15.6 billion, an annual budget of around $3.3 billion, and research funding of over $1 billion. The university fields 19 intercollegiate athletic teams, the Nor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anne McLaren
Dame Anne Laura Dorinthea McLaren, (26 April 1927 – 7 July 2007) was a British scientist who was a leading figure in developmental biology. She paved the way for women in science and her work helped lead to human in vitro fertilisation (IVF). She left an enduring legacy marked by her research and ethical contributions to the field. She received many honors for her contributions to science, including election as fellow of the Royal Society. Early life McLaren was born into a privileged family with notable lineage, as the fourth of five children. She was the daughter of Sir Henry McLaren, 2nd Baron Aberconway, a former Liberal MP, and Christabel Mary Melville MacNaghten. She was born in London and spent her early childhood there, attending private schools. At the age of seven she appeared in the film version of H. G. Wells' novel '' Things to Come'', released in 1936. At the outbreak of World War II, she was 12 years old and her family moved to their estate at Bodnant, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endoderm
Endoderm is the innermost of the three primary germ layers in the very early embryo. The other two layers are the ectoderm (outside layer) and mesoderm (middle layer). Cells migrating inward along the archenteron form the inner layer of the gastrula, which develops into the endoderm. The endoderm consists at first of flattened cells, which subsequently become columnar. It forms the epithelial lining of multiple systems. In plant biology, endoderm corresponds to the innermost part of the cortex ( bark) in young shoots and young roots often consisting of a single cell layer. As the plant becomes older, more endoderm will lignify. Production The following chart shows the tissues produced by the endoderm. The embryonic endoderm develops into the interior linings of two tubes in the body, the digestive and respiratory tube. Liver and pancreas cells are believed to derive from a common precursor. In humans, the endoderm can differentiate into distinguishable organs after 5 w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pluripotent
Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the greater its potency. Potency is also described as the gene activation potential within a cell, which like a continuum, begins with totipotency to designate a cell with the most differentiation potential, pluripotency, multipotency, oligopotency, and finally unipotency. Totipotency Totipotency () is the ability of a single cell to divide and produce all of the differentiated cells in an organism. Spores and zygotes are examples of totipotent cells. In the spectrum of cell potency, totipotency represents the cell with the greatest differentiation potential, being able to differentiate into any embryonic cell, as well as any extraembryonic tissue cell. In contrast, pluripotent cells can only differentiate into embryonic cells. A fully differentiated cell can return to a state of totipotency. The conversion to totipotency is complex and not fully ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ID3 (gene)
DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ''ID3'' gene. Function Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA. upplied by OMIMref name="entrez" /> Interactions ID3 (gene) has been shown to interact with TCF3. Repressors of ID3 BTG2 Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the ''BTG2'' gene (B-cell translocation gene 2) and in other mammals by the ho ... binds to the promoter of Id3 and represses its activity. By this mechanism, the upregulation of Id3 in the hippocampus caused by BTG2 ablation prevents terminal differentiation of hippocampal neurons. See also * Inhibitor of DNA-binding protein References Further reading * * * * * * * * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yamanaka Factors
is a Japanese stem cell researcher and a Nobel Prize laureate. He is a professor and the director emeritus of Center for iPS Cell ( induced Pluripotent Stem Cell) Research and Application, Kyoto University; as a senior investigator at the UCSF-affiliated Gladstone Institutes in San Francisco, California; and as a professor of anatomy at University of California, San Francisco (UCSF). Yamanaka is also a past president of the International Society for Stem Cell Research (ISSCR). He received the 2010 BBVA Foundation Frontiers of Knowledge Award in the biomedicine category, the 2011 Wolf Prize in Medicine with Rudolf Jaenisch, and the 2012 Millennium Technology Prize together with Linus Torvalds. In 2012, he and John Gurdon were awarded the Nobel Prize for Physiology or Medicine for the discovery that mature cells can be converted to stem cells. In 2013, he was awarded the $3 million Breakthrough Prize in Life Sciences for his work. Education Yamanaka was born in H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ontogeny
Ontogeny (also ontogenesis) is the origination and development of an organism (both physical and psychological, e.g., moral development), usually from the time of fertilization of the ovum, egg to adult. The term can also be used to refer to the study of the entirety of an organism's lifespan. Ontogeny is the developmental history of an organism within its own lifetime, as distinct from phylogeny, which refers to the evolutionary history of a species. Another way to think of ontogeny is that it is the process of an organism going through all of the developmental stages over its lifetime. The developmental history includes all the developmental events that occur during the existence of an organism, beginning with the changes in the egg at the time of fertilization and events from the time of birth or hatching and afterward (i.e., growth, remolding of body shape, development of secondary sexual characteristics, etc.). While developmental (i.e., ontogenetic) processes can influen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marine Biological Laboratory
The Marine Biological Laboratory (MBL) is an international center for research and education in biological and environmental science. Founded in Woods Hole, Massachusetts, in 1888, the MBL is a private, nonprofit institution that was independent for most of its history, but became officially affiliated with the University of Chicago on July 1, 2013. It also collaborates with numerous other institutions. As of 2024, 63 Nobel Prize winners have been affiliated with MBL as students, faculty members or researchers. In addition, since 1960, there have been 137 Howard Hughes Medical Institute investigators, early career scientists, international researchers, and professors; 319 members of the National Academy of Sciences; and 260 Members of the American Academy of Arts and Sciences who have been affiliated with the lab. History 19th century The Marine Biological Laboratory grew from the vision of several Bostonians and Spencer Fullerton Baird, the United States' first Fish Commiss ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
