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Calphostin
The calphostins are a class of closely related chemical compounds isolated from the fungus ''Cladosporium cladosporioides''. The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity. Calphostin C Calphostin C is a potent inhibitor of protein kinase C In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and t ... (PKC). References External links *{{Commonscat-inline, Calphostins O-methylated natural phenols Cladosporium 3-Hydroxypropenals within hydroxyquinones ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cladosporium Cladosporioides
''Cladosporium cladosporioides'' is a darkly pigmented mold that occurs world-wide on a wide range of materials both outdoors and indoors. It is known for its role in the decomposition of organic matter and its presence in indoor and outdoor environments. This species is also notable for its potential impact on human health, particularly in individuals with respiratory conditions. It is one of the most common fungi in outdoor air where its spores are important in seasonal allergic disease. While this species rarely causes invasive disease in animals, it is an important agent of plant disease, attacking both the leaves and fruits of many plants. This species produces asexual spores in delicate, branched chains that break apart readily and drift in the air. It is able to grow under low water conditions and at very low temperatures. History and classification Georg Fresenius first species description, described ''Cladosporium cladosporioides'' in 1850, classifying it in the genus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calphostin C
Calphostin C is a natural chemical compound. It is one of the calphostins, isolated from the fungus ''Cladosporium cladosporioides''. Calphostin C is a potent inhibitor of protein kinase C In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and t ... (PKC). References External links O-methylated natural phenols Cladosporium Protein kinase inhibitors Benzoate esters 3-Hydroxypropenals within hydroxyquinones {{Aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme Inhibitor
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its Enzyme activity, activity. Enzymes are proteins that speed up chemical reactions necessary for life, in which Substrate (biochemistry), substrate molecules are converted into Product (chemistry), products. An enzyme Enzyme catalysis, facilitates a specific chemical reaction by binding the substrate to its active site, a specialized area on the enzyme that accelerates the Rate-determining step, most difficult step of the reaction. An enzyme inhibitor stops ("inhibits") this process, either by binding to the enzyme's active site (thus preventing the substrate itself from binding) or by binding to another site on the enzyme such that the enzyme's catalysis of the reaction is blocked. Enzyme inhibitors may bind Reversible reaction, reversibly or irreversibly. Irreversible inhibitors form a Covalent bond, chemical bond with the enzyme such that the enzyme is inhibited until the chemical bond is broken. By cont ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Kinase C
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. In biochemistry, the PKC family consists of fifteen isozymes in humans. They are divided into three subfamilies, based on their second messenger requirements: conventional (or classical), novel, and atypical. Conventional (c)PKCs contain the isoforms α, βI, βII, and γ. These require Ca2+, DAG, and a phospholipid such as phosphatidylserine for activation. Novel (n)PKCs include the δ, ε, η, and θ isoforms, and require DAG, but do not require Ca2+ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calphostins
The calphostins are a class of closely related chemical compounds isolated from the fungus ''Cladosporium cladosporioides''. The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity. Calphostin C Calphostin C is a potent inhibitor of protein kinase C In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and t ... (PKC). References External links *{{Commonscat-inline, Calphostins O-methylated natural phenols Cladosporium 3-Hydroxypropenals within hydroxyquinones ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cladosporium
''Cladosporium'' is a genus of fungi including some of the most common indoor and outdoor molds. Some species are endophytes or plant pathogens, while others parasitize fungi. Description Species produce olive-green to brown or black colonies, and have dark-pigmented conidia that are formed in simple or branching chains. Many species of ''Cladosporium'' are commonly found on living and dead plant material. Including Sunflowers. The spores are wind-dispersed and they are often extremely abundant in outdoor air. Indoors ''Cladosporium'' species may grow on surfaces when moisture is present. '' Cladosporium fulvum'', cause of tomato leaf mould, has been an important genetic model, in that the genetics of host resistance are understood. In the 1960s, it was estimated that the genus ''Cladosporium'' contained around 500 plant-pathogenic and saprotrophic species, but this number has since been increased to over 772 species. The genus is very closely related to black yeasts in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
